Ranade / Cannon Drug Delivery Systems, Third Edition

3. Auflage 2011
ISBN: 978-1-4398-0619-7
Verlag: Taylor & Francis
Format: PDF
Kopierschutz: Adobe DRM (»Systemvoraussetzungen)

E-Book, Englisch, 608 Seiten

Drug delivery technologies represent a vast and vital area of research and development in pharmaceutics. The demand for innovative drug delivery systems continues to grow, and this growth drives a variety of new developments. Building on the foundation provided by the second edition, Drug Delivery Systems, Third Edition covers the latest in research, development, and regulations in industry and academia.

The third edition of this popular book provides a comprehensive review of the latest research and development on drug delivery systems (including liposomal, transmucosal, transdermal, oral, polymeric, and monoclonal antibody directed delivery); it also contains a new chapter on nanoscience and technology for drug delivery along with cutting-edge business intelligence and strategies. These topics are spread into five sections:

- Site-specific drug delivery

- Polymers and implantable drug delivery systems

- Oral drug delivery

- Transdermal, transmucosal, ocular, and miscellaneous drug delivery systems

- Regulatory considerations and global outlook

Written in a straightforward, clear, and concise manner, the authors provide a global perspective on current and future advances and market opportunities. The book answers the need for comprehensive information in a single resource for anyone venturing into this area of drug development and who desires an overview of the field, with extensive guidance on where to gain more information. Each chapter provides a table of marketed and investigational products, with numerous practical examples; the book also provides readers with a multitude of possible drug delivery systems that can be used to improve therapeutics, along with global and regulatory perspectives.

Zielgruppe

Pharmacologists, material scientists working in pharmaceutical companies; chemists and cell biologists working in drug development and delivery systems and in pharmaceutical research; biopharmaceutics/pharmacy departments of universities.

Autoren/Hrsg.

Ranade, Vasant V.

Cannon, John B.

Fachgebiete

• Medizin | Veterinärmedizin Medizin | Public Health | Pharmazie | Zahnmedizin Medizinische Fachgebiete Pharmakologie, Toxikologie

Inhaltsverzeichnis

Site-Specific Drug Delivery Using Liposomes and Emulsions as Carriers
Introduction
Liposomes in Drug Delivery
The Liposome-Drug Concept
Liposomes as Carriers of Therapeutic Agents
Parenteral Emulsions
Recent Advances and Future Prospects
Concluding Remarks
References

Site-Specific Drug Delivery Utilizing Monoclonal Antibodies
Introduction
Production of Monoclonal Antibodies
Drug–Monoclonal Antibody Conjugates for Drug Targeting
Recent Studies with Monoclonal Antibodies
Conclusion and Basis for Future Trends
References

Role of Polymers in Drug Delivery
Introduction
Currently Available Polymers
Soluble Polymers as Drug Carriers
Biodegradable or Bioerodible Polymers
Mucoadhesive Polymers
Polymers Containing Pendant Bioactive Substituents
Matrix Systems
Heparin-Releasing Polymers
Ionic Polymers
Oligomers
Miscellaneous
Recent Advances
Conclusion
References

Implants in Drug Delivery
Introduction
Insulin Delivery as a Model Implant Pump System
Implants for Contraception
Delivery of Chemotherapeutic Agents Using Implants
Recent Advances in Implants and Related Devices (Excluding Inserts)
Future Prospects
References

Oral Drug Delivery
Controlled-Release Formulations
Introduction
Features of the GI Tract
Targeting of Drugs in the GI Tract
Mathematical Models for Controlled-Release Kinetics
Design and Fabrication of Oral Delivery Systems
Survey of Oral Controlled-Release Products
Recent Advances
Current Development of Oral Drug Delivery Systems
Conclusion
References

Enhancing Oral Bioavailability
Introduction
Increasing Bioavailability of Water-Insoluble Drugs
Increasing Bioavailability of Proteins, Peptides, and Other Drugs with Absorption Problems
Recent Advances and Future Prospects
References

Transdermal Drug Delivery
Introduction
Theoretical Aspects of Transdermal Drug Delivery
Development of the Transdermal Therapeutic System
Examples of Transdermal Applications
Recent Advances and Future Prospects
Conclusion
References

Transmucosal and Ocular Drug Delivery
Introduction: Transmucosal and Ocular Drug Delivery
Pulmonary Drug Delivery
Intranasal Drug Delivery
Buccal and Sublingual Drug Delivery
Rectal, Vaginal, and Other Forms of Transmucosal Drug Delivery
Ocular Drug Delivery
Conclusions and Future Outlook for Transmucosal
and Ocular Drug Delivery
References

Miscellaneous Forms of Drug Delivery
Introduction
Pro-Drugs
Infusion Devices
Insulin Delivery
Recent Advances
Summary
References

Nanoscience and Nanotechnology for Drug Delivery
Introduction
Nanotechnologies
Miscellaneous Applications of Nanomaterials
Nanoparticles and Nanostructures
Nanomedicine and Nanopharmaceuticals
References

Regulatory Considerations for Drug Delivery Systems
Introduction
Current Status of Drug Delivery Technology
Submission of Documents for Manufacture and Quality
References

Drug Delivery Industry and the Global Outlook
Basis for the Recent Trend
References

Über Autor(innen)

Vasant V. Ranade is the director of chemical sciences for Academic Pharmaceuticals Inc., in Lake Bluff, Illinois.
John B. Cannon heads his own pharmaceutics and drug delivery consulting company, Targeted Drug Solutions, in Grayslake, Illinois, and serves as a visiting assistant professor at Trinity International University.