Redox Signaling in Wound Healing in Elderly Populations: Clinical Approach, Part 2

Erscheinungsjahr 2025
ISBN: 978-0-443-34515-9
Verlag: Elsevier Science & Technology

Buch, Englisch, Format (B × H): 152 mm x 229 mm

Redox Signaling in Wound Healing in Elderly Populations: Clinical Approach, Part 2 covers wounds in different types and locations (diabetic, ischemic, post-operational) in subcellular and macro dimensions, examine their relationship with aging aim to target deteriorating redox signaling cascades, and will also focus on promising therapeutic approaches. Understanding the indication for the use of new therapeutics targeting the illuminated pathways in wound healing will help adjust treatment regimens befitting modern medicine. Ineffective redox adaptation and disseminated oxidative injury are the hallmarks of continuing oxidative stress. However, oxidative stress cannot be simply described as the imbalance between ROS formation and antioxidant defense capacity; it also covers impairment in redox sensing and signaling pathways. The term oxidative stress is an expression that is losing its use in modern redox biology. It is now an accepted fact that ROS cannot be described as an apparent enemy or friend. Its optimum level modulates signal transduction and stress responses by acting as a second messenger for redox-sensitive cascades. Redox-dependent second messengers are generated in subcellular locations according to specific rules and regulations. Their appearance depends on cellular needs in response to external and internal stimuli variations. A good understanding of the wound healing cascades, which deteriorate especially in advancing ages, is critical in developing the most appropriate approach. To understand the redox signaling mechanisms and healing cascades in wound healing, to pioneer new pharmacoactive drugs that can be developed based on these mechanisms, to reveal the deteriorating dynamics in the elderly patient group, and to propose new treatment methods suitable for the advanced age group.

Autoren/Hrsg.

Weitere Mitwirkende

Cakatay, Ufuk

Can Atayik, Mehmet

Fachgebiete

• Naturwissenschaften Chemie Chemie Allgemein
• Naturwissenschaften Physik Quantenphysik Atom- und Molekülphysik
• Naturwissenschaften Physik Physik Allgemein Theoretische Physik, Mathematische Physik, Computerphysik
• Naturwissenschaften Physik Angewandte Physik Biophysik
• Naturwissenschaften Chemie Physikalische Chemie

Inhaltsverzeichnis

1. Redox state of aging skin: A double-edged sword in wound healing
Qian Chen, Alex Sophabmixay, Thomas Albertson, Gabby Ghasb, Anna Terzian, Lloyd Yan, Lindon Young and Robert Barsotti
2. Redox signaling in pressure ulcers within older population: Role of the of antioxidants in their prevention and management
Catalina Rojas-Solé, Víctor Pinilla-González, José Lillo-Moya and Ramón Rodrigo
3. Redox signaling in intestinal mucosal wound healing
Pavel Markovic and Jan Homolak
4. Gastrointestinal system senility, postsurgical wound healing, and redox signaling pathways
Anil Orhan and Süleyman Demiryas
5. Redox signaling in age-related vascular disease and wound healing
Tamer Cebe, Fatih Kizilyel and Bülend Ketenci
6. Redox signaling in age-related ocular diseases and healing
Ahmad Kunbaz
7. ROS-mediated redox signaling in diabetic wound healing
Saeideh Momtaz and Mohammad Abdollahi
8. Nanotherapeutic approach for diabetic wound healing: Cross-talk between redox molecules
Muhammad Asim, Saadiya Zia, Haroon Ur Rashid, Abdul Nasir and Fatma Hussain
9. Cerium oxide-based redox active antioxidant and anti-inflammatory biomaterial for wound healing applications
Ankitha Suresh, Meghna Shetty and Bhisham Narayan Singh
10. The redox signaling of ozone in wound repair in the elderly. Perspectives for a thorough review about oxygen-ozone adjunct therapy in traumatic and post-surgical wounds
Salvatore Chirumbolo, Marianno Franzini, Umberto Tirelli, Sergio Pandolfi, Giovanni Ricevuti, Francesco Vaiano, Marianna Chierchia and Luigi Valdenassi
11. Contemporary redox-related therapeutic approach to burn wounds in the elderly
Mehmet Kaan Akgün, Sara Koçi, Mehmet Can Atayik and Ömer Cennet

Über Autor(innen)

Can Atayik, Mehmet
Dr. Atayik is currently working in the Department of General Surgery at Hacettepe University Faculty of Medicine. He has been working as a scientist and researcher with Prof. Ufuk Çakatay since 2017. His research interests are in the fields of aging, age-related disorders, redox biology, oncogenetics, melatonin, mitochondria, surgical advances, and developing novel techniques for modern surgery. Dr. Atayik has conducted clinical research and experimental studies. He has published many scientific papers, such as research papers, narrative reviews, and book chapters, and has worked as an author, referee, editorial assistant, and guest editor, and editor in many prominent publishing houses. He was awarded the Young Investigator Presentation Prize at the VIII. International Congress of Molecular Medicine, which was held in Istanbul, Turkey, in November 2021.

Cakatay, Ufuk
Ufuk Çakatay (May 09, 1965 -) is a Turkish biochemist and biogerontologist. He is a full professor of medical biochemistry at Istanbul-University Cerrahpasa in Istanbul, Turkey. He has a long-standing interest in oxidative protein damage, redox signaling, and biomarkers of proteostasis. Much less is known about the relationship between redox signaling events and senescent cells. However, it has been shown that the number of senescent cells in many tissues increases with age and that senescent cells are found in various age-related diseases. The development of experimental animal models for age-related disorders and the optimization of various bioanalytical techniques for the assessment of redox status in aging tissue are among his major research interests. Professor Çakatay has authored more than 100 publications in several leading journals, including research papers, book chapters, editorials, and invited reviews on free radical biology, aging, diabetes, redox signaling, and senotherapeutics. He has been a guest editor, reviewer, and editorial board member for more than 50 journals. In addition, Professor Çakatay has a keen interest in mentoring medical students and promoting their research careers. He has received several prestigious awards, including the Top Reviewer Award from Elsevier Science Publishing, and was a former member of the Animal Research and Ethics Committee of Istanbul University.