Reeves / Derdeyn Entry Inhibitors in HIV Therapy
2007
ISBN: 978-3-7643-7783-0
Verlag: Springer
Format: PDF
Kopierschutz: 1 - PDF Watermark
E-Book, Englisch, 206 Seiten, eBook
Reihe: Milestones in Drug Therapy
ISBN: 978-3-7643-7783-0
Verlag: Springer
Format: PDF
Kopierschutz: 1 - PDF Watermark
Entry Inhibitors in HIV Therapy details the current status of this relatively new and very dynamic class of inhibitors. A unique overview of obstacles and accomplishments is presented. The impact of viral sequence diversity on this class of inhibitors is discussed, and a connection between basic research and clinical studies is shown. The book presents a unique collection of contributors from basic research, pharmaceutical research, and the clinic.
Zielgruppe
Research
Autoren/Hrsg.
Weitere Infos & Material
Introduction to entry inhibitors in the management of HIV infection.- The challenge of HIV sequence diversity in the envelope glycoproteins.- Attachment of human immunodeficiency virus to cells and its inhibition.- Inhibitors that target gp120-CD4 interactions.- Inhibitors that target gp120 interactions with coreceptor.- Inhibitors that target fusion.- Entry inhibitors as microbicides.- Entry inhibition of HIV-1 subtype C isolates.- The utility of coreceptor typing in the clinic.- Future clinical prospects for entry inhibitors.- Enfuvirtide: from basic science to FDA approval.- Targets for drug development – past and present.
