Ripamonti Induction of Bone Formation in Primates

The Transforming Growth Factor
Erscheinungsjahr 2015
ISBN: 978-1-4822-1617-2
Verlag: Taylor & Francis
Format: PDF
Kopierschutz: Adobe DRM (»Systemvoraussetzungen)

E-Book, Englisch, 212 Seiten

The effects of the bone morphogenetic protein family (BMP) of growth factors on bone formation are well documented, but the TGF-beta isoforms are much less studied and have the potential to shed light on the apparent redundancy of bone induction signalling. This edited book sums up the editor's 15 years of research into the osteogenic activity of the TGF-beta growth factor family, particularly in primates. The book awakens skeletal reconstructionists, tissue engineers, and molecular and cellular biologists to the profound and important bone inductive activity of the hTGF-ß3 isoform.

Autoren/Hrsg.

Ripamonti, Ugo

Fachgebiete

• Medizin | Veterinärmedizin Medizin | Public Health | Pharmazie | Zahnmedizin Chirurgie

Inhaltsverzeichnis

Preface
Introduction
Regenerative medicine, bone tissue engineering and the osteogenic proteins of the transforming growth factor-ß (TGF-ß) supergene family
The induction of bone formation by bone morphogenetic proteins and other members of the TGF-ß supergene family
The biological significance of redundancy: The induction of bone formation by the mammalian transforming growth factor-ß1 and -ß2 in non-human primates
Isolation and molecular cloning of the transforming growth factor-ß3 isoform
Rapid induction of bone formation in non-human primates by the transforming growth factor-ß3 isoform
Regeneration of mandibular defects in non-human primates by the transforming growth factor-ß3
Mandibular reconstruction in humans with recombinant human transforming growth factor- ß3
Synergistic induction of bone formation by low doses of TGF-ß1 and TGF-ß3 with recombinant human osteogenic protein-1 (hOP-1), bone morphogenetic protein-7
Perspectives of hTGF-ß3 in regenerative medicine and bone tissue engineering