Riviere Comparative Pharmacokinetics

Principles, Techniques and Applications
2. Auflage 2011
ISBN: 978-0-470-95988-6
Verlag: John Wiley & Sons
Format: EPUB
Kopierschutz: Adobe DRM (»Systemvoraussetzungen)

E-Book, Englisch, 376 Seiten, E-Book

Now in a revised edition, Comparative Pharmacokinetics: Principles, Techniques, and Applications presents the principles and techniques of comparative and veterinary pharmacokinetics in a detailed yet practical manner. Developed as a tool for ensuring that pharmacokinetics studies are properly designed and correctly interpreted, the book provides complete coverage of the conceptual basis of pharmacokinetics as used for quantifying biological processes from the perspectives of physiology and medicine. New chapters have been added on quantitative structure permeability relationships and bioequivalence, and a number of existing chapters have been significantly revised and expanded to provide a current resource for veterinary and comparative pharmacokinetics.

Autoren/Hrsg.

Riviere, Jim E.

Inhaltsverzeichnis

Introduction; Principles of drug movement in the body; Absorption; Distribution; Renal Elimination; Hepatic biotransformation and biliary excretion; Compartmental models; Noncompartmental models; Nonlinear models; Physiological models; Dosage regimens; Simultaneous pharmacokinetics-pharmacodynamics modeling; Study design and data analysis; Population pharmacokinetics models and Bayesian forecasting applied to clinical pharmacokinetics; Dosage adjustment in renal diseases; Interspecies extrapolations; Tissue residues and withdrawal times, Index.

Über Autor(innen)

Jim E. Riviere, D.V.M., Ph.D. is the Burroughs Wellcome Fund Distinguished Professor of Veterinary Pharmacology and Director, Center for Chemical Toxicology Research and Pharmacokinetics, Department of Population Health and Pathobiology, College of Veterinary Medicine, North Carolina State University, Raleigh, N.C. .