Buch, Englisch, 474 Seiten, Format (B × H): 175 mm x 250 mm, Gewicht: 992 g
Buch, Englisch, 474 Seiten, Format (B × H): 175 mm x 250 mm, Gewicht: 992 g
ISBN: 978-0-470-97376-9
Verlag: Wiley
This book fulfils an urgent need for an updated text on pediatric psychopharmacology. It takes a unique approach in discussing recent findings within the context of current issues, including economic and political ones. The book covers the emerging question of treating children who do not yet meet diagnostic criteria for psychosis, e.g, schizophrenia or bipolar disorder, but who are deemed to be at high risk. This is an active area of debate: such children are being treated in certain centers, while others reject this completely. The book addresses the antidepressant controversy, the placebo response and unique strategies for delineating this, and ways to optimize the differential between active medication and placebo. It reviews the impact of recent American Heart Association guidelines for monitoring children on stimulants and other psychotropics. It adheres closely to DSM-IV diagnostic criteria throughout. The book describes the use of newly approved drugs such as Lexapro for treating adolescent depression and the novel compound Intuniv. It covers the TADS and CAMS studies, which evaluated the use of SSRIs alone and in combination with cognitive behavioral therapy for adolescent depression. Other topics include treatment of bipolar disorders, the increasing popularity of generic equivalents, combination pharmacotherapy and the potential dangers of psychotropic medications.
* Third edition of the first ever book published on pediatric psychopharmacology from renowned editors.
* Incorporates current developments with regard to SSRIs, their indications and their safety issues, including possible associated suicidal behavior.
* Addresses concerns about cardiovascular side effects of the new stimulant medications available, and compares to other FDA-approved medications for ADHD.
* Features many tables, figures and pictorials, making it highly accessible and reader friendly.
Autoren/Hrsg.
Fachgebiete
- Medizin | Veterinärmedizin Medizin | Public Health | Pharmazie | Zahnmedizin Medizinische Fachgebiete Pharmakotherapie, Psychopharmakotherapie
- Medizin | Veterinärmedizin Medizin | Public Health | Pharmazie | Zahnmedizin Medizinische Fachgebiete Kinder- & Jugendpsychiatrie
- Medizin | Veterinärmedizin Medizin | Public Health | Pharmazie | Zahnmedizin Medizinische Fachgebiete Neuropharmakologie, Psychopharmakologie
Weitere Infos & Material
List of Contributors, xv
Foreword, xix
Chapter 1 Historical Perspectives on Child and Adolescent Psychopharmacology, 1
Samuel Gershon
References, 4
Chapter 2 Pharmacoepidemiology of Psychotropic Medications in Youth, 7
Daniel J. Safer & Julie Magno Zito
Introduction, 7
Prevalence and trends for medications prescribed for ADHD, 8
Nonstimulant medications for ADHD, 11
Antidepressant medication, 11
Antipsychotic medication, 13
Alpha-agonists, 14
Anticonvulsant "mood stabilizers", 15
Concomitant psychotropic medication, 15
Preschool psychotropic medication use, 17
International patterns of psychotropic medication for youth, 17
Conclusion, 18
References, 18
Chapter 3 Off-Label Prescribing of Drugs in Child and Adolescent Psychiatry, 25
C. Lindsay DeVane
Introduction, 25
Extent of off-label prescribing, 27
Need for psychoactive drug treatments for children and adolescents, 31
Legislation supporting pediatric drug development, 33
Recommendations to follow when considering off-label prescribing, 35
References, 36
Chapter 4 The Use of Generic Drugs in Pediatric Psychopharmacology, 39
Richard I. Shader & Christopher-Paul Milne
What is a generic drug?, 39
Why are we discussing generic drugs?, 39
Basic requirements for generic drugs, 40
The status of regulations regarding generic drugs and children, 41
Abbreviated new drug application (ANDA) requirements, 42
Pediatric assessments of adult drugs (history up to current status), 43
Best Pharmaceuticals for Children Act, 44
Pediatric Research Equity Act, 45
Intersection of requirements for generics and pediatric assessment, 46
Future directions, 48
Concluding thoughts, 49
References, 49
Chapter 5 Psychoactive Drug Use in Children: Basic Concepts in Clinical Pharmacology, 51
David J. Edwards
Introduction, 51
Basic concepts in pharmacokinetics, 52
Dosing considerations for psychoactive drugs in children, 55
Summary, 60
References, 60
Chapter 6 Psychostimulants, 65
Steven R. Pliszka
Introduction, 65
Epidemiology of stimulant use, 66
Structure and biochemical mechanism of action, 66
Neuroimaging studies of stimulant effects, 67
Studies of short-term efficacy, 72
Studies of long-term efficacy, 76
Clinical use, 79
Common side-effects, 84
Cardiovascular safety issues, 86
Growth suppression, 88
Substance use and diversion, 88
Comparison with nonstimulant treatment, 89
Treatment of comorbidity, 92
Pharmacogenetics, 93
Conclusions, 94
References, 94
Chapter 7 Tricyclic Antidepressants and Monoamine Oxidase Inhibitors for the Treatment of Child and Adolescent Psychiatric Disorders, 105
Charlotte M. Heleniak, Tejal Kaur, Kareem D. Ghalib & Moira A. Rynn
Tricyclic antidepressants (TCAs), 105
Drug interactions, contraindications, 116
Monoamine oxidase inhibitors (MAOIs), 117
General summary, 122
References, 123
Chapter 8 Selective Serotonin Reuptake Inhibitors (SSRIs), 131
Dara Sakolsky & Boris Birmaher
Pharmacokinetics, 131
Initiation and titration, 133
Indications and efficacy, 134
Adverse effects, 146
Withdrawal, 149
References, 149
Chapter 9 Novel (Atypical) Antidepressants, 155
Heidi R. Bruty, Graham J. Emslie & Paul Croarkin
Novel (atypical) antidepressants, 155
General overview, 155
Bupropion, 157
Duloxetine, 162
Mirtazapine, 164
Trazodone, 166
Venlafaxine, 170
Desvenlafaxine, 173
Alternative treatments, 174
Summary, 175
References, 176
Chapter 10 Antipsychotic Agents, 181
Brieana M. Rowles, John L. Hertzer & Robert L. Findling
Introduction, 181
Chemical properties, 182
Typical antipsychotics, 183
Atypical antipsychotics, 186
Ethical issues: treatment of at-risk populations, 212
Conclusions, 213
References, 213
Chapter 11 Lithium, 221
Garrett M. Sparks & David A. Axelson
Introduction, 221
Pharmacology, 222
