Buch, Englisch, Band 8, 170 Seiten, Format (B × H): 160 mm x 241 mm, Gewicht: 442 g
Reihe: Focus on Structural Biology
Buch, Englisch, Band 8, 170 Seiten, Format (B × H): 160 mm x 241 mm, Gewicht: 442 g
Reihe: Focus on Structural Biology
ISBN: 978-94-007-5284-9
Verlag: Springer Netherlands
This volume presents a review of the latest numerical techniques used to identify ligand binding and protein complexation sites. It should be noted that there are many other theoretical studies devoted to predicting the activity of specific proteins and that useful protein data can be found in numerous databases. The aim of advanced computational techniques is to identify the active sites in specific proteins and moreover to suggest a generalized mechanism by which such protein-ligand (or protein-protein) interactions can be effected. Developing such tools is not an easy task – it requires extensive expertise in the area of molecular biology as well as a firm grasp of numerical modeling methods. Thus, it is often viewed as a prime candidate for interdisciplinary research.
Zielgruppe
Research
Autoren/Hrsg.
Fachgebiete
- Medizin | Veterinärmedizin Medizin | Public Health | Pharmazie | Zahnmedizin Medizin, Gesundheitswesen Biomedizin, Medizinische Forschung, Klinische Studien
- Naturwissenschaften Biowissenschaften Angewandte Biologie Bioinformatik
- Naturwissenschaften Biowissenschaften Proteinforschung
- Mathematik | Informatik EDV | Informatik Angewandte Informatik Bioinformatik
- Medizin | Veterinärmedizin Medizin | Public Health | Pharmazie | Zahnmedizin Vorklinische Medizin: Grundlagenfächer Molekulare Medizin, Zellbiologie
Weitere Infos & Material
Contributors.- Foreword.- Chapter 1 SuMo: a tool for protein function inference based on 3D structures comparisons, J-A. Chemelle, E. Bettler, CH. Combet, R. Terreux, CH. Geourjon, G. Deleage.- Chapter 2 Identification of pockets on protein surface to predict protein–ligand binding sites, Binding Huang.- Chapter 3 Can the structure of the hydrophobic core determine the complexation site?, M. Banach, L. Konieczny, I. Roterman.- Chapter 4 Comparative analysis of techniques oriented on the recognition of ligand binding area in proteins, P. Alejster, M. Banach, W. Jurkowski, D. Marchewka, I. Roterman.- Chapter 5 Docking predictions of protein-protein interactions and their assessment: the CAPRI experiment, Joel Janin.- Chapter 6 Prediction of protein-protein binding interfaces, D. Marchewka, W. Jurkowski, M. Banach, I. Roterman.- Chapter 7 Support for Cooperative Experiments in e-Science: From Scientific Workflows to Knowledge Sharing, A. Belloum, R. Cushing, S. Koulouzis, V. Korkhov, D. Vasunin, V. Guevara-Masis, Z. Zhao, M. Bubak.- Index
