Sarmento Concepts and Models for Drug Permeability Studies

Cell and Tissue based In Vitro Culture Models
1. Auflage 2015
ISBN: 978-0-08-100114-1
Verlag: Elsevier Science & Techn.
Format: EPUB
Kopierschutz: Adobe DRM (»Systemvoraussetzungen)

E-Book, Englisch, 408 Seiten

This book intends to be an updated compilation of the most important buccal, gastric, intestinal, pulmonary, nasal, vaginal, ocular, skin and blood-brain barrier in vitro models for predicting the permeability of drugs. Concepts and Models for Drug Permeability Studies focuses on different approaches and comprises of various models. Each model describes the protocol of seeding and conservation, the application for specific drugs, and takes into account the maintenance of physiologic characteristics and functionality of epithelium, from the simplest immortalized cell-based monoculture to the most complex engineered-tissue models. Chapters also discuss the equivalence between in vitro cell and tissue models and in vivo conditions, highlighting how each model may provisionally resemble a different drug absorption route. - Updated information regarding the most recent in vitro models to study the permeability of drugs - Short and concise chapters covering all the biological barriers with interest in drug permeability - A combination of bibliographic information related with individual models and footnote instructions of technical procedures for construction of cell and tissue-based models - Simple and clear scientific content, adaptable for young scientists and experimented researchers

BBruno Sarmento is Principal Investigator and Group Leader at Institute for Research and Innovation in Health (i3S), University of Porto (UP), and Invited Associate Professor at Instituto Universitário de Ciências da Saúde (IUCS), Portugal. His research is focused on the development of mucosal tissue engineering models to validate functionalized nanomedicines and to perform in vitro/in vivo correlation. He has also established functionalized nanomedicines for mucosal drug delivery of drug with poor mucosal bioavailability. He published more than 400 papers in international journals, most in top journals (20000 Scopus citations; H-index 73). He edited 5 books, participated in more than 50 invited/selected talks in national and international meetings and was awarded several distinctions. He has supervised/co-supervised 15 Post-Docs, 50 PhD students and 40 MSc students. He is editor of European Journal of Pharmaceutical Sciences, and member of the Editorial Advisory Board of several international journals, including the Journal of Controlled Release, Expert Opinion on Drug Delivery and Pharmaceutics. Bruno Sarmento was the first Chair of the Nanomedicine and Nanoscale Delivery Focus Group of the Controlled Release Society (CRS) and is now Director-at-Large of CRS and member of CRS College of Fellows.

Autoren/Hrsg.

Sarmento, Bruno

Leseproben

List of contributors
João Albuquerque,     University of Porto, Porto, Portugal Isabel Almeida,     University of Porto, Porto, Portugal Fernanda Andrade Laboratory of Pharmaceutical Technology, Faculty of Pharmacy, University of Porto, Porto, Portugal Institute for Bioengineering of Catalonia (IBEC), Barcelona, Spain Francisca Araújo Division of Pharmaceutical Chemistry and Technology, Faculty of Pharmacy, University of Helsinki, Helsinki, Finland INEB—Instituto de Engenharia Biomédica, Universidade do Porto, Porto, Portugal ICBAS—Instituto de Ciências Biomédicas Abel Salazar, Universidade do Porto, Porto, Portugal Marival Bermejo Sanz,     Universidad Miguel Hernández, San Juan de Alicante, Alicante, España Malgorzata Burek,     Department of Anaesthesia and Critical Care, University of Wurzburg, Wurzburg, Germany Miguel Ángel Cabrera Pérez Universidad Central Marta Abreu de Las Villas, Santa Clara, Villa Clara, Cuba Universidad Miguel Hernández, San Juan de Alicante, Alicante, España Pedro Castro,     CBQF—Centro de Biotecnologia e Química Fina—Laboratório Associado, Escola Superior de Biotecnologia, Universidade Católica Portuguesa/Porto, Porto, Portugal Luise Chaves,     UCIBIO/REQUIMTE—Laboratory of Applied Chemistry, University of Porto, Porto, Portugal João Coentro INEB—Instituto de Engenharia Biomédica, Universidade do Porto, Porto, Portugal Faculdade de Engenharia da Universidade do Porto (FEUP), Porto, Portugal Instituto de Ciências Biomédicas Abel Salazar (ICBAS), Universidade do Porto, Porto, Portugal Ana Costa Instituto de Engenharia Biomédica (INEB), University of Porto, Porto, Portugal CESPU, Instituto de Investigação e Formação Avançada em Ciências e Tecnologias da Saúde, Gandra PRD, Portugal Joana Costa INEB—Instituto de Engenharia Biomédica, Universidade do Porto, Porto, Portugal FEUP—Faculdade de Engenharia da Universidade do Porto, Porto, Portugal Paulo Costa,     University of Porto, Porto, Portugal Sara Baptista da Silva Faculty of Pharmacy, University of Porto, Porto, Portugal CBQF—Centro de Biotecnologia e Química Fina—Laboratório Associado, Escola Superior de Biotecnologia, Universidade Católica Portuguesa/Porto, Porto, Portugal José das Neves INEB—Instituto de Engenharia Biomédica, Universidade do Porto, Porto, Portugal Instituto de Investigação e Inovação em Saúde, Universidade do Porto, Porto, Portugal Tiago dos Santos,     INEB—Instituto de Engenharia Biomédica, Universidade do Porto, Porto, Portugal Domingos Ferreira,     Faculty of Pharmacy, University of Porto, Porto, Portugal Carola Y. Förster,     Department of Anaesthesia and Critical Care, University of Wurzburg, Wurzburg, Germany Isabel González Álvarez,     Universidad Miguel Hernández, San Juan de Alicante, Alicante, España Marta González-Álvarez,     Universidad Miguel Hernández, San Juan de Alicante, Alicante, España Luís Gouveia,     iMed.UL, Faculty of Pharmacy, University of Lisbon, Lisbon, Portugal Pedro L. Granja INEB—Instituto de Engenharia Biomédica, Universidade do Porto, Porto, Portugal Faculdade de Engenharia da Universidade do Porto (FEUP), Porto, Portugal Instituto de Ciências Biomédicas Abel Salazar (ICBAS), Universidade do Porto, Porto, Portugal Jouni Hirvonen,     Division of Pharmaceutical Chemistry and Technology, Faculty of Pharmacy, University of Helsinki, Helsinki, Finland Maria João Gomes INEB—Instituto de Engenharia Biomédica, Universisdade do Porto, Porto, Portugal ICBAS—Instituto de Ciências Biomédicas Abel Salazar, Universidade do Porto, Porto, Portugal Instituto de Investigação e Inovação em Saude, Universidade do Porto, Porto, Portugal Christian Kölln,     Institut für Pharmazeutische Technologie, Technische Universität Braunschweig, Braunschweig, Germany Bianca N. Lourenço INEB—Instituto de Engenharia Biomédica, Universidade do Porto, Porto, Portugal Faculdade de Engenharia da Universidade do Porto (FEUP), Porto, Portugal Alexandra Machado INEB—Instituto de Engenharia Biomédica, Universidade do Porto, Porto, Portugal Instituto de Investigação e Inovação em Saúde, Universidade do Porto, Porto, Portugal Raquel Madureira,     CBQF—Centro de Biotecnologia e Química Fina—Laboratório Associado, Escola Superior de Biotecnologia, Universidade Católica Portuguesa/Porto, Porto, Portugal Victor Mangas Sanjuan,     Universidad Miguel Hernández, San Juan de Alicante, Alicante, España Sara Marques,     CIBIO/InBIO-UP—Centro de Investigação em Biodiversidade e Recursos Genéticos, University of Porto, Campus Agrário, Vairão, Portugal Susana Martins,     University of Southern Denmark, Odense, Denmark Bárbara Mendes INEB—Instituto de Engenharia Biomédica, Universidade do Porto, Porto, Portugal Instituto de Investigação e Inovação em Saude, Universidade do Porto, Porto, Portugal José Augusto Guimarães Morais,     iMed.UL, Faculty of Pharmacy, University of Lisbon, Lisbon, Portugal Rute Nunes,     INEB—Instituto de Engenharia Biomédica, University of Porto, Porto, Portugal Maria Beatriz P.P. Oliveira,     Requimte, Faculty of Pharmacy, University of Porto, Porto, Portugal Paulo Paixão,     iMed.UL, Faculty of Pharmacy, University of Lisbon, Lisbon, Portugal Carla Pereira INEB—Instituto de Engenharia Biomédica, Universidade do Porto, Porto, Portugal FEUP—Faculdade de Engenharia da Universidade do Porto, Porto, Portugal Manuela Pintado,     CBQF—Centro de Biotecnologia e Química Fina—Laboratório Associado, Escola Superior de Biotecnologia, Universidade Católica Portuguesa/Porto, Porto, Portugal Stephan Reichl,     Institut für Pharmazeutische Technologie, Technische Universität Braunschweig, Braunschweig, Germany Francisca Rodrigues Requimte, Faculty of Pharmacy, University of Porto, Porto, Portugal Fourmag Lda, Parque Industrial do Cruzeiro, Moreira de Cónegos, Portugal Ellaine Salvador,     Department of Anaesthesia and Critical Care, University of Wurzburg, Wurzburg, Germany Hélder A. Santos,     Division of Pharmaceutical Chemistry and Technology, Faculty of Pharmacy, University of Helsinki, Helsinki, Finland Bruno Sarmento Instituto de Investigação e Inovação em Saúde, Universidade do Porto, Porto, Portugal INEB—Instituto de Engenharia Biomédica, Universidade do Porto, Porto, Portugal CESPU, Instituto de Investigação e Formação Avançada em Ciências e Tecnologias da Saúde, Instituto Superior de Ciências da Saúde-Norte, Departamento de Ciências Farmacêuticas, Gandra-PRD, Portugal Neha Shrestha,     Division of Pharmaceutical Chemistry and Technology, Faculty of Pharmacy, University of Helsinki, Helsinki, Finland Cátia Silva,     CESPU, Instituto de Investigação e Formação Avançada em Ciências e Tecnologias da Saúde, Gandra PRD, Portugal Nuno Silva,     iMed.UL, Faculty of Pharmacy, University of Lisbon, Lisbon, Portugal Nataša Škalko-Basnet,     University of Tromsø The Arctic University of Norway, Tromsø, Norway Alejandro Sosnik,     Technion-Israel Institute of Technology, Technion City, Haifa, Israel Flávia Sousa,     CESPU, Instituto de Investigação e Formação Avançada em Ciências e Tecnologias da Saúde, Instituto Superior de Ciências da Saúde-Norte, Gandra PRD, Portugal Ingunn Tho,     University of Oslo, Oslo, Norway Ana Vanessa Nascimento University of Porto, Porto, Portugal IINFACTS, Instituto de Investigação e Formação Avançada em Ciências e Tecnologias da Saúde, CESPU, Cooperativa...