Sasic Pharmaceutical Applications of Raman Spectroscopy

1. Auflage 2008
ISBN: 978-0-470-22587-5
Verlag: John Wiley & Sons
Format: PDF
Kopierschutz: Adobe DRM (»Systemvoraussetzungen)

E-Book, Englisch, 280 Seiten, E-Book

Raman spectroscopy has advanced in recent years with increasing useboth in industry and academia. This is due largely to steadyimprovements in instrumentation, decreasing cost, and theavailability of chemometrics to assist in the analysis of data.
Pharmaceutical applications of Raman spectroscopy have developedsimilarly and this book will focus on those applications. Carefullyorganized with an emphasis on industry issues, PharmaceuticalApplications of Raman Spectroscopy, provides the basic theory ofRaman effect and instrumentation, and then addresses a wide rangeof pharmaceutical applications. Current applications that areroutinely used as well as those with promising potential arecovered. Applications cover a broad range from discovery tomanufacturing in the pharmaceutical industry and includeidentifying polymorphs, monitoring real-time processes, imagingsolid dosage formulations, imaging active pharmaceuticalingredients in cells, and diagnostics.

Autoren/Hrsg.

Sasic, Slobodan

Weitere Mitwirkende

Ekins, Sean

Inhaltsverzeichnis

Preface.
Contributors.
1. Introduction to Raman Spectroscopy (Yukihiro Ozakiand Slobodan Sasic).
1.1 Histor of Raman Spectrodcopy.
1.2. The Principle of Raman Spectroscopy.
1.3 An Example of Simpel Raman Spectrum: Raman Spectrum ofWater.
1.4 Characteristics of Raman Spectroscopy.
1.5 The Classic Theory fo Raman Effect.
1.6 The Quantum Theory of Raman Scattering.
1.7 Ctross Section.
1.8 Relevance to Pharmaceuticals.
1.9 Resonance Raman Effect.
1.10 Instrumentation for Raman Spectroscopy.
2. Quantitative Analysis of Solid Dosage Formulations byRaman Spectroscopy (Steven E.J.Bell).
2.1 Introduction.
2.2 Quantitative Analysis.
2.3 Instrumental Parameters.
2.4 Experimental Considerations.
2.5 Nonstandard Samples.
2.6 Conclusions.
3. Surface Enhanced Resonance Raman Scatttering (W.Ewen Smith).
3.1 Theory.
3.2 The Exper4imental Setup.
3.3 Examples of SERS/SERRS Assays.
4. Raman Spectroscopy for Identifying Polymorphs (FredLaplant and Anne De Paepe).
4.1 Introduction of Polymorphism.
4.2 Instrumental Methods of Polymorph Characterization.
4.3 Polymorph Screening.
4.4 Process Control.
4.5 Polymorph Quantitation.
4.6 Calibration Set and Sample Preparation.
4.7 Quantitation.
4.8 Intellectual Property.
5. Raman Spectroscopy for Monitoring Real-time Processes inthe Pharmaceutical Industry (Kevin L. Davis, Mark S. Kemperand Ian R. Lewis).
5.1 Introduction.
5.2 A Brief History of Raman Spectroscopy.
5.3 Basic Theory of Raman Spectroscopy.
5.4 General Instrumentation for Raman Spectroscopy.
5.5 The Choice-Dispersive or FT?.
5.6 Process Analysis and PAT.
5.7 Why Choose Raman as a PAT Tool? The Need for Raman.
5.8 Data Analysis.
5.9 Applications.
5.10 Conclusions.
6. Raman Chemical Imaging of Solid Dosage Formulations(Slobodan Sasic).
6.1 Methods for Chemcial Imaging.
6.2 Data Analysis.
6.3 Experimental.
6.4 Applications.
7. In vivo Raman Confocal Microspectroscopy of Skin(Andre van der Pol, William M. Riggs and Peter J.Caspers).
7.1 Introduction.
7.2 Applications.
7.3 Summary and Discussion.
8. Raman Microspectrscopy and Imgaging of ActivePharmaceutical Ingredients in Cells (Jian Ling).
8.1 Introduction.
8.2 Current Appraoches to Drug Imaging.
8.3 Raman Spectroscopy and Raman Imaging.
8.4 Raman Microspectroscopy and Imaging for Drug Research.
8.5 Raman Intensity, Fluorescence Background, and SNR.
8.6 Techniques to Improve SNR in Raman Imaging.
8.7 Enhanced Raman Images with Postprocessing.
8.8 Raman Imaging of Intracellular Distribution of Paclitaxel inLiving Cells.
8.9 Raman Imaging of Intracellular Distribution of SulindacSulfide in Fixed Cells.
8.10 Conclusions and Future Outlook.
Index.

Über Autor(innen)

Principal Scientist, Analytical Research & Development, Pfizer, Inc., Sandwich, UK