Schmidt-Traub Preparative Chromatography

of Fine Chemicals and Pharmaceutical Agents
1. Auflage 2006
ISBN: 978-3-527-60590-3
Verlag: Wiley-VCH
Format: PDF
Kopierschutz: Adobe DRM (»Systemvoraussetzungen)

E-Book, Englisch, 458 Seiten, E-Book

Die präparative Chromatographie ist ein Verfahren zur Reinigung auch kleiner Mengen von Produkten in kürzester Zeit. In diesem interdisziplinär angelegten Band erfahren Chemiker und Ingenieure, was sie im Alltag über naturwissenschaftliche und technologische Grundlagen dieser Methode wissen müssen und wie sie chromatographische Prozesse optimieren können. Dabei wird die Arbeit im Labormaßstab ebenso berücksichtigt wie die Konzeption industrieller Anlagen.-Derzeit gibt es am Markt kein anderes Buch mit ähnlichem Themenspektrum.

Autoren/Hrsg.

Schmidt-Traub, Henner

Inhaltsverzeichnis

INTRODUCTION Liquid Chromatography - It's History Focus of the Book How to read this Book? FUNDAMENTALS AND GENERAL TERMINOLOGY Principles of Adsorption Chromatography Basic Effects and Chromatographic Definitions Fluid Dynamics Mass Transfer Phenomena Equilibrium Thermodynamics Thermodynamic Effects on Mass Separation Practical Aspects of Parameter Determination COLUMNS, PACKINGS AND STATIONARY PHASES Column Design Column Packings Column Packing Technology Column Testing Column Maintenance and Regeneration Guidelines for Choosing Chromatographic Columns and Stationary Phases SELECTION OF CHROMATOGRAPHIC SYSTEMS Definition of the Task Properties of Chromatographic Systems Criteria for the Choice of Chromatographic Systems PROCESS CONCEPTS Design and Operation of Equipment Discontinuous Processes Continuous Processes Guidelines MODELLING AND DETERMINATION OF MODEL PARAMETERS Introduction Models for Single Chromatographic Columns Modelling HPLC Plants Numerical Methods Parameter Determination Validation of Column Models Modelling of SMB-Processes MODEL BASED DESIGN AND OPTIMISATION Basic Principles Batch Chromatography SMB Chromatography Comparison of Batch and SMB Chromatography CHROMATOGRAPHIC REACTORS Introduction Types of Chromatographic Reactors Modelling of Chromatographic Reactors Operation and Design of Chromatographic Reactors Design Examples ADVANCED CONTROL OF SIMULATED MOVING BED PROCESSES Introduction Model Predictive Control State of the Art in Control of Simulated Moving Bed Processes Online Optimising Control of a Reactive Simulated Moving Bed Process Conclusions APPENDIX

INTRODUCTION Liquid Chromatography - It's History Focus of the Book How to read this Book? FUNDAMENTALS AND GENERAL TERMINOLOGY Principles of Adsorption Chromatography Basic Effects and Chromatographic Definitions Fluid Dynamics Mass Transfer Phenomena Equilibrium Thermodynamics Thermodynamic Effects on Mass Separation Practical Aspects of Parameter Determination COLUMNS, PACKINGS AND STATIONARY PHASES Column Design Column Packings Column Packing Technology Column Testing Column Maintenance and Regeneration Guidelines for Choosing Chromatographic Columns and Stationary Phases SELECTION OF CHROMATOGRAPHIC SYSTEMS Definition of the Task Properties of Chromatographic Systems Criteria for the Choice of Chromatographic Systems PROCESS CONCEPTS Design and Operation of Equipment Discontinuous Processes Continuous Processes Guidelines MODELLING AND DETERMINATION OF MODEL PARAMETERS Introduction Models for Single Chromatographic Columns Modelling HPLC Plants Numerical Methods Parameter Determination Validation of Column Models Modelling of SMB-Processes MODEL BASED DESIGN AND OPTIMISATION Basic Principles Batch Chromatography SMB Chromatography Comparison of Batch and SMB Chromatography CHROMATOGRAPHIC REACTORS Introduction Types of Chromatographic Reactors Modelling of Chromatographic Reactors Operation and Design of Chromatographic Reactors Design Examples ADVANCED CONTROL OF SIMULATED MOVING BED PROCESSES Introduction Model Predictive Control State of the Art in Control of Simulated Moving Bed Processes Online Optimising Control of a Reactive Simulated Moving Bed Process Conclusions APPENDIX

Über Autor(innen)

Henner Schmidt-Traub has gained 15 years of industrial experience in plant engineering. Since 1989 he has been Professor for Plant and Process Design at the Department of Biochemical and Chemical Engineering, University of Dortmund. His main areas of research focus on preparative chromatography, down stream processing, integrated processes, plant design and innovative energy transfer.