Sebti / Hamilton Farnesyltransferase Inhibitors in Cancer Therapy

Erscheinungsjahr 2000
ISBN: 978-1-59259-013-1
Verlag: Humana Press
Format: PDF
Kopierschutz: 1 - PDF Watermark

E-Book, Englisch, 280 Seiten, eBook

Reihe: Cancer Drug Discovery and Development

Zielgruppe

Professional/practitioner

Autoren/Hrsg.

Sebti, Saïd M.

Hamilton, Andrew D.

Inhaltsverzeichnis

1 Signal Transduction Pathways: A Goldmine for Therapeutic Targets.- 2 The Biochemistry of Farnesyltransferase and Geranylgeranyltransferase I.- 3 Structures of Protein Farnesyltransferase.- 4 Peptidomimetic-Based Inhibitors of Farnesyltransferase.- 5 Antitumor Efficacy of a Farnesyltransferase Inhibitor in Transgenic Mice.- 6 Development of Farnesyltransferase Inhibitors as Potential Antitumor Agents.- 7 Tricyclic Farnesyl Protein Transferase Inhibitors: Antitumor Activity and Effects on Protein Prenylation.- 8 Histidylbenzylglycinamides: A Novel Class of Farnesyl DiphosphateCompetitive Peptidic Farnesyltransferase Inhibitors.- 9 From Random Screening of Chemical Libraries to the Optimization of FPP-Competitive Inhibitors of Farnesyltransferase.- 10 Genetic Analysis of FTase and GGTase I and Natural Product Farnesyltransferase Inhibitors.- 11 Effects of Farnesyltransferase Inhibitors on Cytoskeleton, Cell Transformation, and Tumorigenesis: The FTI-Rho Hypothesis.- 12 Prenyltransferase Inhibitors as Radiosensitizers.- 13 Farnesyltransferase and Geranylgeranyltransferase I Inhibitors as Novel Agents for Cancer and Cardiovascular Diseases.- 14 Protein Prenylation in Trypanosomatids: A New Piggy-Back Medicinal Chemistry Target for the Development of Agents Against Tropical Diseases.- 15 Early Clinical Experience with Farnesyl Protein Transferase Inhibitors: From the Bench to the Bedside.- 16 Phase I Trial of Oral R115777 in Patients with Refractory Solid Tumors: Preliminary Results.- 17 Farnesyltransferase and Geranylgeranyltransferase Inhibitors: The Saga Continues.