Sewald / Jakubke Peptides: Chemistry and Biology

2. Auflage 2015
ISBN: 978-3-527-80265-4
Verlag: Wiley-VCH
Format: EPUB
Kopierschutz: Adobe DRM (»Systemvoraussetzungen)

E-Book, Englisch, 578 Seiten, E-Book

Der "Sewald/Jakubke" ist und bleibt das einzige moderne, auf dem neuesten wissenschaftlichen Stand gehaltene fortgeschrittene Lehrbuch der Peptid-Biochemie! Auch für diese zweite, um ein Viertel erweitere Auflage haben die Autoren Hunderte von Publikationen gelesen und zu einem informativen und vollständigen Überblick über das Fachgebiet zusammengefasst. Nach einer Einführung in die Grundlagen der Peptidstruktur und -synthese werden die wichtigsten Familien biologisch aktiver Peptide systematisch abgehandelt. Mit interdisziplinärem Anspruch werden dann wichtige Anwendungen aus der Biotechnologie, Pharmazie und Biomedizin besprochen. Selbstverständlich werden auch Themen der Spitzenforschung berücksichtigt, zum Beispiel Pseudopeptide, Peptidmimetika und Aspekte der kombinatorischen Synthese. -- Neu in dieser Auflage sind Fragen und Übungsaufgaben, die das Nacharbeiten von Vorlesungen oder das Selbststudium erleichtern.

Autoren/Hrsg.

Sewald, Norbert

Jakubke, Hans-Dieter

Inhaltsverzeichnis

INTRODUCTION AND BACKGROUND FUNDAMENTAL CHEMICAL AND STRUCTURAL PRINCIPLES Definitions and Main Conformational Features of the Peptide Bond Building Blocks, Classification, and Nomenclature Analysis of the Covalent Structure of Peptides and Proteins Three-Dimensional Structure Methods of Structural Analysis BIOLOGY OF PEPTIDES Historical Aspects and Biological Functions Biosynthesis Selected Biologically Active Peptides PEPTIDE SYNTHESIS Principles and Objectives Protection of Functional Groups Peptide Bond Formation Racemization During Synthesis Solid-Phase Peptide Synthesis (SPPS) Biochemical Synthesis SYNTHESIS CONCEPTS FOR PEPTIDES AND PROTEINS Strategy and Tactics Solution Phase Synthesis (SPS) NEW: Solution Phase/Solid Phase-Hybrid Approaches Optimized Strategies on Polymeric Support Chemical Ligation Strategies SYNTHESIS OF SPECIAL PEPTIDES AND PEPTIDE CONJUGATES Cyclopeptides Cystine Peptides Glycopeptides Phosphopeptides Lipopeptides Sulfated Peptides PEPTIDE AND PROTEIN DESIGN, PSEUDOPEPTIDES, AND PEPTIDOMIMETICS Peptide Design Modified Peptides Peptidomimetics Pseudobiopolymers Macropeptides and De-Novo Design of Peptides and Proteins COMBINATORIAL PEPTIDE SYNTHESIS Parallel Synthesis Synthesis of Mixtures APPLICATION OF PEPTIDES AND PROTEINS NEW: General Production Strategies NEW: Improvement of the Therapeutic Potential Protein Pharmaceuticals Peptide Pharmaceuticals PEPTIDES IN PROTEOMICS NEW: Genome and Proteome NEW: Separation Methods NEW: Peptide and Protein Analysis in Proteomics NEW: Activity-Based Proteomics

Über Autor(innen)

Norbert Sewald studied Chemistry at the Technical University of Munich, Germany, where he also obtained his PhD degree. After postdoctoral work with J. E. Baldwin in Oxford, UK, he became an Assitant Professor at Leipzig University. Since 1999 he is full Professor at the University of Bielefeld where he holds the chair in Organic and Bioorganic Chemistry. His main scientific interest is in peptide chemistry, bioactive peptides., and their application in biochemistry and medical sciences. He has authored more than 120 publications and together with Hans-Dieter Jakubke, has written the book Peptides from A - Z, also published by Wiley-VCH.   Hans-Dieter Jakubke studied Chemistry at the Martin-Luther-University Halle-Wittenberg, Germany. After finishing his PhD and postdoctoral work with Josef Rudinger in Prague (Czeck Republic), he was appointed Assistant Professor at the Department of Biochemistry in Halle, and Full Professor of Biochemistry at the University of Leipzig in 1977. He was director of the Department of Biochemistry from 1993-1997 and member of the Council of the European Peptide Society from 1990-1994. He authored several textbooks and encyclopedias on various aspects of chemistry and biochemistry including peptide research.