Peroxisomes: Biogenesis, Function, and Role in Human Disease

1. Auflage 2019
ISBN: 978-981-15-1171-4
Verlag: Springer Nature Singapore

Buch, Englisch, 279 Seiten, Format (B × H): 155 mm x 235 mm, Gewicht: 508 g

This book provides readers with a comprehensive overview of peroxisomes and their role in human diseases. It starts by describing the history of peroxisome research and then examines in detail the current understanding of the biogenesis and function of peroxisomes. It then focuses on peroxisomal disorders and the involvement of peroxisomes in cancer and age-related diseases, discussing in detail the use of model organisms to elucidate the pathogenesis of peroxisomal disorders and the physiological importance of peroxisomal proteins. Further, the book examines diagnostic and therapeutic strategies in peroxisomal disorders as well as significant recent advances. Lastly, it addresses various topics in peroxisome research, including the isolation of peroxisomes from mammalian tissues and cells, the structural biology of peroxisomal proteins, the lipidomics of peroxisomal disorders, the value of exome sequencing, and neuropsychological testing in X-linked adrenoleukodystrophy. Given itsscope, the book is a valuable resource for postgraduate students and researchers in the life sciences and clinicians in the fields of internal medicine, pediatrics, and neurology.

Zielgruppe

Research

Autoren/Hrsg.

Shimozawa, Nobuyuki

Imanaka, Tsuneo

Fachgebiete

• Naturwissenschaften Biowissenschaften Tierkunde / Zoologie
• Naturwissenschaften Biowissenschaften Biochemie (nichtmedizinisch)
• Medizin | Veterinärmedizin Medizin | Public Health | Pharmazie | Zahnmedizin Vorklinische Medizin: Grundlagenfächer Physiologie
• Naturwissenschaften Biowissenschaften Zellbiologie

Inhaltsverzeichnis

Part 1 Biogenesis and Function of peroxisome.- 1 The history of peroxisomal research.- 2 Peroxisome Biogenesis.- 3 Peroxisome Degradation and Its Molecular Machinery.- 4 The function of the peroxisome.- Part 2 Dysfunction of Peroxisome and Human Disease.- 5 Peroxisomal disorders.- 6 Model organisms used to understand peroxisomal disorders.- 7 Diagnosis of peroxisomal disorders.- 8 Therapeutic strategies for X-linked adrenoleukodystrophy, a representative peroxisome disease.- Part 3 Topics in Peroxisome Research.- 9 The isolation of peroxisomes.- 10 Structure Biology of peroxisomal proteins, peroxins.- 11 Lipidomics of peroxisomal disorders.- 12 Neurophysiology and neuropsychology for X-ALD. 

Über Autor(innen)

Tsuneo Imanka, Faculty of Pharmaceutical Sciences, Hiroshima International University, JapanNobuyuki Shimozawa, Division of Genomics Research, Life Science Research Center, Gifu University, Japan