Oral Delivery of Insulin

Erscheinungsjahr 2014
ISBN: 978-1-907568-47-3
Verlag: Woodhead Publishing

Buch, Englisch, 290 Seiten, Format (B × H): 156 mm x 234 mm, Gewicht: 680 g

Diabetes Mellitus, a syndrome of disordered metabolism, characterised by abnormal elevation in blood glucose level, has become a life-threatening condition for many people. Current means of therapy for Diabetes Mellitus do not mimic the normal physiological pattern of insulin release. Oral delivery is the preferred route of administration due to its non-invasive nature. Oral delivery of insulin presents an overview of Diabetes Mellitus, and discusses the strategies and techniques adopted for oral delivery of insulin. This title begins with an introductory chapter on symptoms, complications and therapy for Diabetes Mellitus. Subsequent chapters cover the various routes for administering insulin; the challenges and strategies of oral delivery; experimental techniques in the development of an oral insulin carrier; lipids; inorganic nanoparticles and polymers in oral insulin delivery; and a summary and presentation of future perspectives on oral delivery of insulin.

Autoren/Hrsg.

Sonia, T.A.

Sharma, Chandra P.

Fachgebiete

• Medizin | Veterinärmedizin Medizin | Public Health | Pharmazie | Zahnmedizin Klinische und Innere Medizin Diabetologie
• Medizin | Veterinärmedizin Medizin | Public Health | Pharmazie | Zahnmedizin Medizinische Fachgebiete Pharmakologie, Toxikologie

Inhaltsverzeichnis

- List of figures and tables - Figures
- Tables

- About the authors
- 1: Diabetes mellitus - an overview - Abstract
- 1.1 Diabetes mellitus - an introduction
- 1.2 Glucose homeostasis
- 1.3 Types of diabetes
- 1.4 Symptoms of diabetes
- 1.5 Complications of diabetes
- 1.6 Diagnosis of diabetes mellitus
- 1.7 Therapy for diabetes
- 1.8 Non-insulin treatment options of type 1 diabetes
- 1.9 Treatment options of type 2 diabetes
- 1.10 Conclusion

- 2: Routes of administration of insulin - Abstract
- 2.1 Current approach for the delivery of insulin
- 2.2 Routes of administration of insulin
- 2.3 Conclusion

- 3: Oral insulin delivery - challenges and strategies - Abstract
- 3.1 Oral delivery of insulin
- 3.2 Barriers to oral delivery of insulin
- 3.3 Strategies and alternatives to improve oral insulin delivery
- 3.4 Conclusion

- 4: Experimental techniques involved in the development of oral insulin carriers - Abstract
- 4.1 Introduction
- 4.2 Polymeric nanoparticles
- 4.3 Physicochemical characterization of nanoparticles
- 4.4 Biological evaluation
- 4.5 In vitro method for assessing drug permeability
- 4.6 In vivo study of oral insulin
- 4.7 Biodistribution studies
- 4.8 Conclusion

- 5: Lipids and inorganic nanoparticles in oral insulin delivery - Abstract
- 5.1 Lipid-based systems for oral delivery of insulin
- 5.2 Liposomes
- 5.3 Solid lipid nanoparticles
- 5.4 Nanostructured lipid carriers
- 5.5 Niosomes
- 5.6 Archaeosomes
- 5.7 Cubic nanoparticles (cubosomes)
- 5.8 Aquasomes
- 5.9 Inorganic nanoparticles as carriers for oral insulin delivery
- 5.10 Conclusion

- 6: Polymers in oral insulin delivery - Abstract
- 6.1 Introduction
- 6.2 Characteristics of an ideal oral insulin carrier
- 6.3 Polymers in oral insulin delivery
- 6.4 Natural polymers
- 6.5 Synthetic polymers
- 6.6 Conclusion

- 7: Summary and future perspectives for oral insulin delivery - Abstract
- 7.1 Introduction
- 7.2 Technologies developed for clinical applications of oral insulin delivery
- 7.3 Conclusions and future perspectives

- Index

Über Autor(innen)

Sonia, T.A.
Sonia T.A pursued her PhD under the guidance of Dr Chandra P Sharma at the Biosurface Technology Division, Sree Chitra Tirunal Institute for Medical Science & Technology in Kerala, India. She worked in the field of development of polymeric nano/micro particles for oral delivery of insulin. She completed her graduate studies in Polymer science from the School of Chemical Sciences, Mahatma Gandhi University, Kerala India. She has presented her work in International Conferences.

Sharma, Chandra P.
Dr. Chandra P. Sharma is Adjunct Professor, Department of Pharmaceutical Biotechnology, Manipal College of Pharmaceutical Sciences, Manipal University, and Hon. Emeritus Professor, College of Biomedical Engineering & Applied Sciences, Purbanchal University, Kathmandu, Nepal. Dr. Sharma is a Solid-State Physicist from IIT Delhi and received his training in Biomaterials area in the University of Utah with Prof. D.J. Lyman as a graduate student and in the University of Liverpool, England with Prof. D.F. Williams as a Post-Doctoral Research Associate. Dr. Sharma has been awarded FBSE (Fellow Biomaterials Science & Engineering) by The International Union of Societies for Biomaterials Science & Engineering (IUS-BSE) in 2008 and FBAO (Fellow Biomaterials and Artificial Organs) by Society for Biomaterials & Artificial Organs (India) (SBAOI) in 2011 and shares Whitaker and National Science Foundation Award - International Society for Artificial Organs (ISAO) USA, invited member ACS (2015-2018).

T. A. Sonia is a doctoral student working in the field of development of polymeric nano/micro particles for oral delivery of insulin under the guidance of Dr Chandra P Sharma at Biosurface Technology Division, Biomedical Technology Wing, Sree Chitra Tirunal Institute for Medical Science & Technology, Kerala, India. She completed her graduate studies in Polymer Science from School of Chemical Sciences, Mahatma Gandhi University, Kerala, India.

Chandra P. Sharma is the Acting Head of Biomedical Technology Wing and Associate Dean - PhD Programme, Sree Chitra Tirunal Institute for Medical Science & Technology, Kerala, India, and has been the Head of the Biosurface Technology Division since 1980. His areas of expertise include: biomaterials science and engineering; polymeric and metallic micro/nano particles based delivery systems; and surface modification and tissue/blood compatibility of materials. Dr. Sharma has published over 325 research papers with over 2600 citations (Scopus) and has processed 32 patents including in Canada, European Union, Japan and USA. He has served as guest editor and reviewer of several international journals and has edited books with Dr. Michael Szycher on Blood Compatible Materials and Devices, and on Biointegration of medical implant materials: Science and design, with Woodhead Publishing. His laboratory has completed leading research in the field.