Stress and The Brain: Evidence from Molecular Mechanisms to Interventions and Therapies

Erscheinungsjahr 2025
ISBN: 978-0-443-34425-1
Verlag: Elsevier Science & Technology

Buch, Englisch, Format (B × H): 152 mm x 229 mm

Stress and The Brain: Evidence from Molecular Mechanisms to Interventions and Therapies is a comprehensive exploration of how stress affects the brain at a molecular level and its broader implications for mental and neurological health. The book delves into the mechanisms by which stress triggers changes in brain function, including the activation of the hypothalamic-pituitary-adrenal (HPA) axis, synaptic plasticity alterations, oxidative stress, neuroinflammation, and mitochondrial dysfunction. It examines how these molecular processes contribute to conditions such as neurodegeneration, anxiety, depression, and other stress-related disorders. Furthermore, the book provides an in-depth analysis of current therapeutic interventions, both pharmacological and behavioral, as well as natural antidotes that aim to mitigate the adverse effects of stress on the brain. By synthesizing evidence from cutting-edge research, this book offers valuable insights for scientists, clinicians, and mental health professionals seeking to understand and address the complex interplay between stress and brain health.

Autoren/Hrsg.

Weitere Mitwirkende

Orish, Chinna

Fachgebiete

• Interdisziplinäres Wissenschaften Wissenschaften Interdisziplinär Neurowissenschaften, Kognitionswissenschaft
• Sozialwissenschaften Psychologie Allgemeine Psychologie Biologische Psychologie, Neuropsychologie

Inhaltsverzeichnis

1. Introduction to physiology and neurobiology of stress
2. Mechanisms underlying stress effects on the brain
3. Early Life Stress and Brain Development: Neurobiological and behavioral effects of chronic stress
4. Molecular mechanisms underlying stress response and adaptation
5. The Effects of Stress on Cognitive Performance
6. Stress and sleep: What's the link?
7. Stress-Related psychiatric disorders
8. Stress and the Gut Microbiota-Brain Axis
9. Epigenetic Regulation of Stress
10. Mapping Neural Networks in Stress-Brain Connectivity
11. Stress-related Neurodegenerative Diseases: Molecular Mechanisms Implicated in Neurodegeneration and Therapeutic Strategies
12. The Stress-Immune System Axis: Exploring the Interplay Between Stress and Immunity
13. Stress and Gender Differences in Brain Development
14. Models developed to explain the effects of stress on brain and behaviour
15. Novel treatment and strategies targeting stress-related disorders
16. Stress in Specific Population: Cognitive Decline in Aging, Occupational Challenges, Strategies for Medical Professionals”
17. Addiction and Stress: Exploring the reward pathways in brain affected by different drugs
18. Stress-Induced Neurodegeneration and Behavioral Alterations in Caenorhabditis elegans: Insights into the Evolutionary Conservation of Stress-Related Pathways and Implications for Human Health
19. The Neuroscientific Basis of Post-Traumatic Stress Disorder (PTSD): From Brain to Treatment
20. Effect of stress on neuronal cells: Morphological to molecular approach

Über Autor(innen)

Orish, Chinna
Dr. Chinna Orish is an MBBS graduate with a PhD in Anatomy and is a Senior Faculty member at the University of Port Harcourt, Nigeria. She completed her postdoctoral fellowship in Neurotoxicology at the National Center for Toxicological Research, USA, from 2016 to 2017. She is the founder of Women in Neuroscience and the Youth Neuroscience Association of Nigeria, where she is dedicated to empowering young minds and promoting gender equality in the field of neuroscience. Additionally, she serves as the lead investigator at the Neuro-Provictoire Research Laboratory, spearheading pioneering research initiatives. She coordinates the Neuroscience Group at the University of Port Harcourt, Nigeria, significantly contributing to the academic and research environment. Her active involvement in international scientific communities is evident through her memberships in prestigious organizations such as the International Society of Neurochemistry, the American Society of Neurochemistry, the Society for Neuroscience, and the Neuroscience Society of Nigeria. These affiliations reflect her commitment to staying at the forefront of global developments in neuroscience. Her research focuses on understanding sexual dimorphism in the molecular mechanisms of heavy metal-induced environmental toxicants in neurodegenerative and neurodevelopmental disorders, using both animal and Drosophila models. Her work has also shed light on the potential therapeutic roles of natural products in mitigating the adverse effects of environmental toxins on the nervous system. This research is crucial as it bridges the gap between basic neuroscience and practical therapeutic applications, offering hope for new treatments and preventative strategies in neurodegenerative diseases. Her expertise is also recognized in the academic publishing world, where she serves as an editor for several prestigious journals, including the American Journal of Psychiatry and Neuroscience, the Journal of Life Neuroscience (NeuroLife), the British Journal of Medicine and Medical Research, the Journal of Human Anatomy, and Clinical and Experimental Anatomy. Chinna's contributions to neuroscience have been acknowledged through numerous awards from reputable organizations, including the International Brain Research Organization (IBRO) and the International Society for Neurochemistry (ISN). These accolades highlight her impact on the field and her ongoing commitment to advancing neuroscience research and education. She has several publications in reputable journals, contributing valuable knowledge and insights to the scientific world.