Structural and Mechanistic Enzymology: | Buch | 978-0-12-398312-1 | sack.de

Buch, Englisch, 472 Seiten, Format (B × H): 152 mm x 229 mm, Gewicht: 900 g

Structural and Mechanistic Enzymology:

Bringing Together Experiments and Computing
Erscheinungsjahr 2012
ISBN: 978-0-12-398312-1
Verlag: Academic Press

Bringing Together Experiments and Computing

Buch, Englisch, 472 Seiten, Format (B × H): 152 mm x 229 mm, Gewicht: 900 g

ISBN: 978-0-12-398312-1
Verlag: Academic Press


Both strategies for investigation (computational and experimental) in structural and mechanistic Enzymology have developed to some extent independently. However, over the last few years a trend has emerged for strengthening their integration. This combination not only brings together computations and experiments focused on the same enzymatic problems, but also provides complementary insights into the investigated properties and has a powerful synergy effect. This thematic volume of Advances in Protein Chemistry and Structural Biology focuses on the recent success in structural and mechanistic enzymology and has its main emphasis on explaining the enzyme phenomena by using both the experimental and computational approaches. The selected contributions demonstrate how the application of a variety of experimental techniques and modeling methods helps further the understanding of enzyme dynamics, mechanism, inhibition, and drug design.


Focuses on the recent success in structural and mechanistic enzymology. Has its main emphasis on explaining the enzyme phenomena by using both the experimental and computational approaches. Demonstrates how the application of a variety of experimental techniques and modeling methods helps further the understanding of enzyme dynamics, mechanism, inhibition, and drug design.
Structural and Mechanistic Enzymology: jetzt bestellen!

Zielgruppe


Biochemists, biophysicists, cell biologists, protein chemists, structural geneticists, and structural biologists

Weitere Infos & Material


Structural and Computational Enzymology: Bringing Experiments and Computations Together Tatyana Karabencheva and Christo Christov Structural and Functional Analysis of Proteins by High-Speed Atomic Force Microscopy Arivazhagan Rajendran, Masayuki Endo and Hiroshi Sugiyama Reaction Intermediates Discovered in Crystal Structures of Enzymes Irene T. Weber, Johnson Agniswamy, Guoxing Fu, Chen-Hsiang Shen and Robert W. Harrison Structural, Functional and Mutagenesis Studies of UDP-Glycosyltransferases Vatsala Malik and Gary W Black Vipoxin and its Components: Structure - Function Relationship S. D. Petrova, V. N. Atanasov and K. Balashev Experimental and Theoretical Studies of Enzyme-Catalyzed Hydrogen Transfer Reactions Zhen Wang, Daniel Roston and Amnon Kohen Protein Flexibility and Enzymatic Catalysis M. Kokkinidis, N. M. Glykos and V. E. Fadouloglou Molecular Modeling of Inhibitors of Human DNA Methyltransferase with a Crystal Structure: Discovery of a Novel DNMT1 Inhibitor Jakyung Yoo, Joo Hee Kim, Keith D. Robertson and José L. Medina-Franco In Silico Strategies Towards Enzyme Function and Dynamics Sílvia G. Estácio Dynamic Simulations as a Complement to Experimental Studies of Enzyme Mechanisms Andrew Christofferon, Lifeng Zhao and Qiang Pei The Increasing Role of QM/MM in Drug Discovery Alessio Lodola and Marco De Vivo Probing Allostery and Binding Cooperativity of the Catalytic Subunit of Protein Kinase A by NMR Spectroscopy and Molecular Dynamics Simulations Larry R. Masterson, Alessandro Cembran, Lei Shi and Gianluigi Veglia Using a Combination of Computational and Experimental Techniques to Understand the Molecular Basis for Protein Allostery Wanting Jiao and Emily J. Parker


Ihre Fragen, Wünsche oder Anmerkungen
Vorname*
Nachname*
Ihre E-Mail-Adresse*
Kundennr.
Ihre Nachricht*
Lediglich mit * gekennzeichnete Felder sind Pflichtfelder.
Wenn Sie die im Kontaktformular eingegebenen Daten durch Klick auf den nachfolgenden Button übersenden, erklären Sie sich damit einverstanden, dass wir Ihr Angaben für die Beantwortung Ihrer Anfrage verwenden. Selbstverständlich werden Ihre Daten vertraulich behandelt und nicht an Dritte weitergegeben. Sie können der Verwendung Ihrer Daten jederzeit widersprechen. Das Datenhandling bei Sack Fachmedien erklären wir Ihnen in unserer Datenschutzerklärung.