Handbook of Comparative Veterinary Pharmacokinetics and Residues of Pesticides and Environmental Contaminants

1. Auflage 1995
ISBN: 978-0-8493-3213-5
Verlag: CRC Press

Buch, Englisch, 592 Seiten, Format (B × H): 178 mm x 254 mm, Gewicht: 1360 g

Residues of drugs and chemicals in edible tissues of food-producing animals are a major public health concern. Until now, information on applications of pharmacokinetic principles to drug and chemical residue avoidance has been spread throughout literature. For the first time, this handbook brings this information together in a convenient and concise volume.
For easier reference, text is divided into three parts: physicochemical constants and chemical structures, legal tissue tolerances, and pharmacokinetic parameters derived from open literature. This is the only publication that offers all this information in a single source. For fast access, numerous tables present valuable pharmacokinetic data for drugs in serum, plasma, or blood and in other matrices. The authors include their own previously unpublished pharmacokinetic parameters, results of statistical analyses performed on time/concentration data tabulated in the primary sources. Helpful appendices contain FDA approved tolerances and action levels as well as chemical structures and physicochemical properties. This is an essential handbook for veterinarians, toxicologists, pharmacologists, animal scientists, food hygienists, and regulatory personnel involved in human food safety.

Autoren/Hrsg.

Sundlof, Stephen F.

Riviere, Jim E.

Craigmill, Arthur L.

Fachgebiete

• Naturwissenschaften Agrarwissenschaften Ackerbaukunde, Pflanzenbau Schädlingsbekämpfung
• Technische Wissenschaften Umwelttechnik | Umwelttechnologie Umwelttechnik
• Geowissenschaften Umweltwissenschaften Umwelttechnik

Inhaltsverzeichnis

Principles of PharmacokineticsIntroductionDrug Disposition OverviewDistributionEliminationAbsorptionPharmacokineticsCompartmental SystemsMultiple Dose AdministrationExtravascular Drug AdministrationStatistical ConsiderationsPrinciples of Interspecies ExtrapolationSelected Readings and ReferencesOrientation to Chapters and TablesChlorinated Hydrocarbon InsecticidesIntroduction and Selected ReadingsTable 3A: Pharmacokinetic Data for Drugs in Serum, Plasma, or BloodTable 3B: Pharmacokinetic Data for Drugs in Other MatricesReferencesOrganophosphate and Carbamate InsecticidesIntroduction and Selected ReadingsTable 4A: Pharmacokinetic Data for Drugs in Serum, Plasma, or BloodTable 4B: Pharmacokinetic Data for Drugs in Other MatricesReferencesHerbicidesIntroduction and Selected ReadingsTable 5A: Pharmacokinetic Data for Drugs in Serum, Plasma, or BloodTable 5B: Pharmacokinetic Data for Drugs in Other MatricesReferencesRodenticidesIntroduction and Selected ReadingsTable 6A: Pharmacokinetic Data for Drugs in Serum, Plasma, or BloodTable 6B: Pharmacokinetic Data for Drugs in Other MatricesReferencesMiscellaneous Pesticides and AntidotesIntroduction and Selected ReadingsTable 7A: Pharmacokinetic Data for Drugs in Serum, Plasma, or BloodTable 7B: Pharmacokinetic Data for Drugs in Other MatricesReferencesMycotoxinsIntroduction and Selected ReadingsTable 8A: Pharmacokinetic Data for Drugs in Serum, Plasma, or BloodTable 8B: Pharmacokinetic Data for Drugs in Other MatricesReferencesEnvironmental ContaminantsIntroduction and Selected ReadingsTable 9A: Pharmacokinetic Data for Drugs in Serum, Plasma, or BloodTable 9B: Pharmacokinetic Data for Drugs in Other MatricesReferencesAppendix A: FDA Approved Tolerances and Action LevelsAppendix B: Chemical Structures and Physicochemical PropertiesIndex