TAM Receptors in Health and Disease

Erscheinungsjahr 2020
ISBN: 978-0-12-821822-8
Verlag: William Andrew Publishing

Buch, Englisch, 176 Seiten, Format (B × H): 152 mm x 229 mm, Gewicht: 410 g

TAM Receptors in Health and Disease, Volume 357 in the International Review of Cell and Molecular Biology, reviews the role of TAM receptors in health and diseases. Chapters in this new release include TAM receptors and its Role in Efferocytosis: Clearance of Dead Cells, TAM family receptors and their ligands: Role in thrombosis, TAM receptors and its ligand mediated activation: Role in Atherosclerosis, Post-translational modifications of the Ligands: Requirement for TAM receptor activation, Immunogenic role of TAM receptors in the cancer microenvironment: Implications in cancer immunotherapy, TAM receptors: A Phosphatidylserine Receptor family and its implications in Viral infections, and much more.

Zielgruppe

<p>Physicians, Immunologist, Cancer Patients and their family members</p>

Autoren/Hrsg.

Weitere Mitwirkende

Davra, Viralkumar

Fachgebiete

• Naturwissenschaften Biowissenschaften Molekularbiologie
• Medizin | Veterinärmedizin Medizin | Public Health | Pharmazie | Zahnmedizin Klinische und Innere Medizin Onkologie, Krebsforschung
• Naturwissenschaften Biowissenschaften Entwicklungsbiologie
• Naturwissenschaften Biowissenschaften Zellbiologie
• Medizin | Veterinärmedizin Medizin | Public Health | Pharmazie | Zahnmedizin Klinische und Innere Medizin Immunologie

Inhaltsverzeichnis

1. Recent advancements in role of TAM receptors on efferocytosis, viral infection, autoimmunity, and tissue repair

Annika Ranta and Sushil Kumar

2. TAM receptors and their ligand-mediated activation: Role in atherosclerosis

Bishuang Cai and Canan Kasikara

3. Post-translational modifications of the Ligands: Requirement for TAM receptor activation

Ke Geng

4. Immunological role of TAM receptors in the cancer microenvironment

Varsha Gadiyar, Gopi Patel and Viralkumar Davra

5. TAM receptors: A phosphatidylserine receptor family and its implications in viral infections

Ghosh Roy, Sounak

6. Autophagic cell death in viral infection: Do TAM receptors play a role?

Emmanuel Datan and Shaima Salman

Über Autor(innen)

Davra, Viralkumar
Viralkumar Davra is an accomplished biochemist and molecular biologist working currently as a postdoctoral fellow in Raymond Birge's laboratory at the Rutgers University. He has received Bachelor of Pharmacy degree from the Rajiv Gandhi University, Bangalore (2008), followed by M.Sc. in Pharmacology and Toxicology at Long Island University (2012) and Ph.D. in Molecular biology and cancer genetics from Rutgers University (2019). He has identified and validated a novel therapeutic target, Mertk receptor, and developed first-in-class anti-Mertk monoclonal antibody in collaboration with pharmaceutical companies. The antibody has shown strong anti-tumor efficacy in combination with immune checkpoint inhibitors and is currently being developed for clinical trial studies. Further, he has also invented and developed novel Phosphatidylserine (PS) targeting immuno-biologicals (Gas6-IFN fusion proteins) and shown them to be effective as anti-cancer therapeutic in the breast, colon and melanoma mouse models as well as anti-viral therapeutics by using highly infectious influenza mouse model. His work has direct implication in the health care industry with pressing need of highly effective therapeutics for cancer and infectious diseases. He has published about 14 peer reviewer publications, filled 2 patents internationally and won 3 prestigious awards during his Graduate study.