Tegtmeyer / Backert Molecular Pathogenesis and Signal Transduction by Helicobacter pylori

1. Auflage 2017
ISBN: 978-3-319-50520-6
Verlag: Springer International Publishing
Format: PDF
Kopierschutz: 1 - PDF Watermark

E-Book, Englisch, Band 400, 347 Seiten, eBook

Reihe: Current Topics in Microbiology and Immunology

This volume reviews the current state of research concerning bacterial virulence factors and the infection biology of Helicobacter pylori , which is the leading cause of peptic ulcers and gastric cancer worldwide. The chapters include cutting-edge findings on this fascinating microbe and discuss the general strategies of H. pylori infection and persistence, news on important H. pylori virulence factors, crosstalk with the microbiota, hot novel models and signaling mechanisms, risk factors of gastric disease and stomach cancer, and the impact of H. pylori infection on non-gastric diseases. Written by internationally respected scientists, this book will appeal to clinicians, researchers and advanced students alike.

Zielgruppe

Research

Autoren/Hrsg.

Tegtmeyer, Nicole

Backert, Steffen

Inhaltsverzeichnis

The human stomach in health and disease: infection strategies by Helicobacter pylori.- Human and Helicobacterpylori Interactions Determine the Outcome of Gastric Diseases.- Immune evasion strategies and persistence of Helicobacterpylori.- Recent advances in Helicobacter pylori replication: possible implications in adaptation to a pathogenic lifestyle and perspectives for drug design.- The Helicobacterpylori Methylome: Roles in Gene Regulation and Virulence.- Structural insights into Helicobacterpylori Cag protein interactions with host cell factors.- Gastric organoids: An emerging model system to study Helicobacterpylori pathogenesis.- DNA Transfer and Toll-Like Receptor Modulation by Helicobacter pylori.- Exploiting the gastric epithelial barrier: Helicobacter pylori’s attack on tight and adherens junctions.- Helicobacterpylori -induced Changes in Gastric Acid Secretion and Upper Gastrointestinal Disease.- Impact of the microbiota and gastric disease development by Helicobacterpylori.- Pathogenesis of gastric cancer: genetics and molecular classification.- Helicobacterpylori -mediated genetic instability and gastric carcinogenesis.- Helicobacterpylori and extragastric diseases.

Über Autor(innen)

Dr. rer. nat. Nicole Tegtmeyer Prof. Dr. rer. nat. Steffen Backert Chair of Microbiology Friedrich Alexander University Erlangen/Nuremberg Department of Biology, Division of Microbiology Staudtstr. 5 91058 Erlangen Germany