The Neurobiology of C. elegans

1. Auflage 2006
ISBN: 978-0-08-047861-6
Verlag: Elsevier Science & Techn.
Format: PDF
Kopierschutz: 1 - PDF Watermark

E-Book, Englisch, Band Volume 69, 248 Seiten, Web PDF

Reihe: International Review of Neurobiology

The Neurobiology of C. elegans assembles together a series of chapters describing the progress researchers have made toward solving some of the major problems in neurobiology with the use of this powerful model organism. The first chapter is an introduction to the anatomy of the C. elegans nervous system. This chapter provides a useful introduction to this system and will help the reader who is less familiar with this system understand the chapters that follow. The next two chapters on learning, conditioning and memory and neuronal specification and differentiation, summarize the current state of the C. elegans field in these two major areas of neurobiology. The remaining chapters describe studies in C. elegans that have provided particularly exciting insights into neurobiology.

Autoren/Hrsg.

Inhaltsverzeichnis

1;Cover;1
2;Title;2
3;Series Editors;3
4;Copyright;5
5;Contents;6
6;Contributors;10
7;Preface;12
8;Chapter 1: Nematode Neurons: Anatomy and Anatomical Methods in Caenorhabditis elegans;15
8.1;I. Introduction;16
8.2;II. Categorization of Neuron Cell Fates;19
8.3;III. What Defines a Neuron? Synapses, Scaffolds, and Pioneers;28
8.4;IV. Neuron Ultrastructure;31
8.5;V. Methods for Analytical Study of Neurons in C. elegans;38
8.6;References;44
9;Chapter 2: Investigations of Learning and Memory in Caenorhabditis elegans;51
9.1;I. Introduction;52
9.2;II. Mechanosensory Learning and Memory;54
9.3;III. Chemosensory Learning and Memory;66
9.4;IV. Thermosensory Learning and Memory;75
9.5;V. Conclusions;81
9.6;References;82
10;Chapter 3: Neural Specification and Differentiation;87
10.1;I. Introduction;88
10.2;II. HOM-C Genes;93
10.3;III. Basic Helix-Loop-Helix Genes;95
10.4;IV. Neurogenesis of the Touch Receptor Neurons;100
10.5;V. The LIM Hypothesis;105
10.6;VI. Mutations That Cause the Partial Loss of Neuronal Identity;106
10.7;VII. Conclusions;107
10.8;References;107
11;Chapter 4: Sexual Behavior of the Caenorhabditis elegans Male;113
11.1;I. In C. elegans, Sex is the Male's Responsibility;114
11.2;II. Mate-Searching Demonstrates Motivated Behavior in the Worm;115
11.3;III. Hermaphrodite Cues Influence Male Locomotory Behavior;115
11.4;IV. Male Copulatory Behavior can be Broken Down into a Series of Sub-Behaviors;117
11.5;V. The Gender-Specific Anatomy and Nervous System of the Male Develop Postembryonically;120
11.6;VI. The Fan Facilitates the Male's Contact with the Hermaphrodite Body;120
11.7;VII. Each Sub-Behavior of the Copulatory Sequence is Promoted by Sensory Input from Particular Sensory Neurons;122
11.8;VIII. The Rays Convey Complex Spatial Information;123
11.9;IX. Hook, Post-Cloacal Sensilla, and Spicules Detect the Vulva;126
11.10;X. Spicule Insertion Anchors the Male and Triggers Ejaculation;127
11.11;XI. The Male's Copulatory Nervous System can Take Over Control of the Rest of the Nervous System;128
11.12;XII. Male Development Results from Gender-Specific Utilization of a Largely Common Set of Genes;129
11.13;XIII. DM Domain Transcription Factors may Represent Primordial Male-Determining Genes;129
11.14;XIV. Response to Contact and Vulva Location Require Genes of the TRP Channel Superfamily of Putative Mechanosensitive Channels;131
11.15;XV. Multiple Cholinergic Pathways Regulate the Muscle Contractions Controlling Spicule Behavior;131
11.16;XVI. Prospects;134
11.17;References;135
12;Chapter 5: The Motor Circuit;139
12.1;I. Introduction;140
12.2;II. An Overview of C. elegans Motor Circuit Anatomy;140
12.3;III. Genetic Control of Motor Neuron Differentiation;154
12.4;IV. How Does It Work?;167
12.5;V. Conclusions and Future Directions;172
12.6;References;174
13;Chapter 6: Mechanosensation in Caenorhabditis elegans;183
13.1;I. Introduction;184
13.2;II. Gentle Touch;187
13.3;III. Harsh Touch;200
13.4;IV. Osmolarity;201
13.5;V. Nose Touch;201
13.6;VI. Texture-Mediated Slowing;205
13.7;VII. Proprioception and Sinusoidal Locomotion;206
13.8;VIII. Male Mating and Location of the Vulva;207
13.9;IX. Conclusions and Future Directions;210
13.10;References;210
14;Index;219
15;Contents of Recent Volumes;227