Chemistry and Pharmacology of Anticancer Drugs

1. Auflage 2006
ISBN: 978-0-8493-9219-1
Verlag: Taylor & Francis Inc

Buch, Englisch, 312 Seiten, Format (B × H): 162 mm x 242 mm, Gewicht: 615 g

While drug therapies developed in the last 50 years have markedly improved the management of some types of cancers, treatment outcomes, and drug side-effects for the most common types remain unacceptable.  However, recent technological advances are leading to improved therapies based on targeting distinct biological pathways in cancer cells. Chemistry and Pharmacology of Anticancer Drugsis a comprehensive survey of all families of anticancer agents currently in use or in advanced stages of clinical trials, including biologicals. The book is unique in providing molecular structures for all anticancer drugs, discussing them in terms of history, chemistry, mechanism of action, structure-function relationships, and pharmacology. It also provides some relevant information on side effects, dosing, and formulation. The author, a renowned scientist in cancer research and drug development, also provides up-to-date information on the drug discovery process, including new research tools, tumor-targeting strategies, and fundamental concepts in the emerging areas of personalized medicine (e.g., oncogenomics) and chemoprevention. Chemistry and Pharmacology of Anticancer Drugsis an indispensable resource for cancer researchers, medicinal chemists, and other biomedical scientists involved in the development of new anticancer treatments. Its breadth of coverage also makes it suitable for undergraduate and postgraduate courses in medicine, pharmacy, nursing, and related disciplines.

Zielgruppe

Researchers including medicinal chemists, chemists, pharmacologists, biomedical and clinical scientists working on cancer chemotherapy agents in both industrial and academic settings.  Those teaching or taking both undergraduate and postgraduate courses in medicine, pharmacy, nursing or related disciplines.

Autoren/Hrsg.

Thurston, David E.

Fachgebiete

• Medizin | Veterinärmedizin Medizin | Public Health | Pharmazie | Zahnmedizin Medizinische Fachgebiete Pharmakologie, Toxikologie
• Medizin | Veterinärmedizin Medizin | Public Health | Pharmazie | Zahnmedizin Klinische und Innere Medizin Onkologie, Krebsforschung
• Naturwissenschaften Chemie Chemie Allgemein Pharmazeutische Chemie, Medizinische Chemie

Inhaltsverzeichnis

INTRODUCTION TO CANCER Terminology Metastases Diagnosis and Screening Formation of Cancer Cells (Tumorigenesis) Mechanisms of Genomic Damage Treatments Discovery of Anticancer Drugs and Preclinical Evaluation Accessibility of Drugs to Tumor Cells Achieving Selective Toxicity Limiting the Toxicity of Chemotherapeutic Agents Overview of Mechanisms of Action of Chemotherapeutic Agents Drug Resistance Combination Chemotherapy Use of Adjuvants Infertility Following Cancer Treatments ANTIMETABOLITES DHFR Inhibitors (Antifolates) Purine Antimetabolites Pyrimidine Antimetabolites Thymidylate Synthase Inhibition Adenosine Deaminase Inhibition Ribonucleotide Reductase Inhibition DNA-INTERACTIVE AGENTS Alkylating Agents Cross-Linking Agents Intercalating Agents Topoisomerase Inhibitors DNA-Cleaving Agents ANTITUBULIN AGENTS Vinca Alkaloids The Taxanes MOLECULARLY TARGETED AGENTS Kinase Inhibitors Inhibition of Ras Pathway Signaling Cell Cycle Inhibitors Proteasome Inhibitors mTOR Inhibitors HORMONAL THERAPIES Breast Cancer Prostatic Cancer Neuroendocrine Tumors: Somatostatin Analogs Estrogen Therapy Progestogen Therapy TUMOR-TARGETING STRATEGIES Antibody-Based Approaches Vascular-Targeting Strategies X-DEPT (Biphasic) Strategies Enzymatic Targeting Photoactivated Drugs (Photodynamic Therapy) Boron Neutron Capture Therapy Novel Drug Delivery Approaches BIOLOGICAL AGENTS Biological Response Modifiers Immunotherapy Enzyme-Based Therapies Vaccines THE FUTURE Novel Biological Targets and Therapeutic Strategies New Research Tools and Methodologies Chemopreventive Agents PERSONALIZED TREATMENTS Screening for Risk of Disease Development Prognosis and Staging Screening for Risk of Recurrence of Disease Selecting Best Treatments for Patients Predicting Side Effects of Chemotherapeutic Agents Pharmacogenomics in Clinical Trials ADJUNCT THERAPIES Anti-emetic Agents Steroidal Agents Adjuvent Enzymes Other Therapies Index *Each chapter includes an Introduction and a Further Reading section.

Über Autor(innen)

University of London, UK London, WC1N 1AX