Nanomaterials in Drug Delivery, Imaging, and Tissue Engineering

1. Auflage 2013
ISBN: 978-1-118-29032-3
Verlag: Wiley

Buch, Englisch, 576 Seiten, Format (B × H): 163 mm x 236 mm, Gewicht: 930 g

This comprehensive volume provides the reader valuable insight into the major areas of biomedical nanomaterials, advanced nanomedicine, nanotheragnostics, and cutting-edge nanoscaffolds.

The ability to control the structure of materials allows scientists to accomplish what once appeared impossible before the advent of nanotechnology. It is now possible to generate nanoscopic self-assembled and self-destructive robots for effective utilization in therapeutics, diagnostics, and biomedical implants. Nanoscopic therapeutic systems incorporate therapeutic agents, molecular targeting, and diagnostic imaging capabilities and they have emerged as the next generation of multifarious nanomedicine to improve the therapeutic outcome including chemo and translational therapy.

Nanomaterials in Drug Delivery, Imaging, and Tissue Engineering comprises fifteen chapters authored by senior scientists, and is one of the first books to cover nanotheragnostics, which is the new developmental edge of nanomedicine combining both diagnostic and therapeutic elements at the nano level. This large multidisciplinary reference work has four main parts: biomedical nanomaterials; advanced nanomedicine; nanotheragnostics; and nanoscaffolds technology.

This groundbreaking volume also covers:

- Multifunctional polymeric nanostructures for therapy and diagnosis
- Metalla-assemblies acting as drug carriers
- Nanomaterials for management of lung disorders and drug delivery
- Responsive polymer-inorganic hybrid nanogels for optical sensing, imaging, and drug delivery
- Core/shell nanoparticles for drug delivery and diagnosis
- Theranostic nanoparticles for cancer imaging and therapy
- Magnetic nanoparticles in tissue regeneration
- Core-sheath fibers for regenerative medicine

Autoren/Hrsg.

Tiwari, Ashutosh

Tiwari, Atul

Fachgebiete

• Technische Wissenschaften Maschinenbau | Werkstoffkunde Technische Mechanik | Werkstoffkunde Materialwissenschaft: Biomaterialien, Nanomaterialien, Kohlenstoff
• Technische Wissenschaften Sonstige Technologien | Angewandte Technik Medizintechnik, Biomedizintechnik
• Medizin | Veterinärmedizin Medizin | Public Health | Pharmazie | Zahnmedizin Medizin, Gesundheitswesen Medizintechnik, Biomedizintechnik, Medizinische Werkstoffe
• Technische Wissenschaften Technik Allgemein Nanotechnologie
• Technische Wissenschaften Verfahrenstechnik | Chemieingenieurwesen | Biotechnologie Biotechnologie Biotechnologie: Mikrotechnologie, Nanobiotechnologie

Inhaltsverzeichnis

Preface xv

Part I: Biomedical nanomaterials

1 Nanoemulsions: Preparation, Stability and Application in Biosciences 1
Thomas Delmas, Nicolas Atrux-Tallau, Mathieu Goutayer, SangHoon Han, Jin Woong Kim, and Jérôme Bibette

1.1 Introduction 2

1.2 Nanoemulsion:A Thermodynamic Definition and Its Practical Implications 5

1.3 Stable Nanoemulsion Formulation 9

1.4 Nanoencapsulation in Lipid Nanoparticles 21

1.5 Interactions between Nanoemulsions and the Biological Medium: Applications in Biosciences 35

1.6 General Conclusion 47

References 48

2 Multifunctional Polymeric Nanostructures for Therapy and Diagnosis 57
Angel Contreras-García and Emilio Bucio

2.1 Introduction 58

2.2 Polymeric-based Core-shell Colloid 61

2.3 Proteins and Peptides 64

2.4 Drug Conjugates and Complexes with Synthetic Polymers 65

2.5 Dendrimers, Vesicles, and Micelles 67

2.6 Smart Nanopolymers 71

2.7 Stimuli Responsive Polymer-metal Nanocomposites 75

2.8 Enzyme-responsive Nanoparticles 78

Acknowledgements 83

References 83

3 Carbon Nanotubes: Nanotoxicity Testing and Bioapplications 97
R. Sharma and S. Kwon

3.1 Introduction 98

3.2 Historical Review of Carbon Nanotube 99

3.3 Carbon Nanotubes (CNTs) and Other Carbon Nanomaterials 100

3.4 Motivation - Combining Nanotechnology and Surface Science with Growing Bioapplications 104

3.5 Cytotoxicity Measurement and Mechanisms of CNT Toxicity 111

3.6 MSCs Differentiation and Proliferation on Different Types of Scaffolds 120

3.7 New Lessons on CNT Nanocomposites 130

3.8 Conclusions 135

Part II: Advanced nanomedicine

4 Discrete Metalla-Assemblies as Drug Delivery Vectors 149
Bruno Therrien

4.1 Introduction 149

4.2 Complex-in-a-Complex Systems 150

4.3 Encapsulation of Pyrenyl-functionalized Derivatives 155

4.4 Exploiting the Enhanced Permeability and Retention Effect 159

4.5 Incorporation of Photosensitizers in Metalla-assemblies 162

4.6 Conclusion 165

Acknowledgments 165

References 166

5 Nanomaterials for Management of Lung Disorders and Drug Delivery 169
Jyothi U. Menon, Aniket S. Wadajkar, Zhiwe iXie, and Kytai T. Nguyen

5.1 Lung Structure and Physiology 170

5.2 Common Lung DiseasesAnd Treatment Methods 171

5.3 Types of Nanoparticles (NPs) 173

5.4 Methods for Pulmonary Delivery 179

5.5 Targeting Mechanisms 184

5.6 TherapeuticAgents Used for Delivery 188

5.7 Applications 191

5.8 Design Considerations of NPs 195

5.9 Current Challenges and Future Outlook 197

6 Nano-Sized Calcium Phosphate (CaP) Carriers for Non-Viral Gene/Drug Delivery 199
Donghyun Lee, Geunseon Ahn and Prashant N. Kumta

6.1 Introduction 200

6.2 Vectors for Gene Delivery 202

6.3 Modulation of Protection and Release Characteristics of Calcium Phosphate Vector 213

6.4 Calcium Phosphate Carriers for Drug Delivery Systems 219

6.5 Variants of Nano-calcium Phosphates: Future Trends of the CaPDelivery Systems 221

Acknowledgements 223

References 223

7 Organics ModifiedMesoporous Silica for Controlled Drug Delivery Systems 233
Jingke Fu, Yang Zhao, Yingchun Zhu and Fang Chen

7.1 Introduction 233

7.2 Controlled Drug Delivery Systems Based on Organics Modified

7.3 Conclusions 258

References 259

Part III: Nanotheragnostics

8 Responsive Polymer-Inorganic Hybrid Nanogels for Optical Sensing, Imaging, and Drug Delivery 263
Weitai Wu and Shuiqin Zhou

8.1 Introduction 264

8.2 Mechanisms of Response 268

8.3 Synthesis of Responsive Polymer-inorganic Hybrid Nanogels 285

8.4 Applications 293

References 306

9 Core/Shell Nanoparticles for Drug Delivery and Diagnosis 315
Hwanbum Lee, Jae Yeon Kim, Eun Hee Lee, Young In Park, Keun Sang Oh, Kwangmeyung Kim, Ick Chan Kwonand Soon Hong Yuk

9.2 Core/Shell NPs from Polymeric Micelles 319

9.3 Phospholipid-based Core/Shell Nanoparticles 325

9.4 Layer-by-Layer-Assembled Core/Shell Nanoparticles 329

9.5 Core/Shell NPs for Diagnosis 330

9.4 Conclusions 331

Acknowledgments 331

References 331

10 Dendrimer Nanoparticles and Their Applications in Biomedicine 339
Arghya Paul, Wei Shao, Tom J. Burdon, Dominique Shum-Tim and Satya Prakash

10.1 Introduction 340

10.2 Dendrimers and Their Characteristics 341

10.3 Biomolecular Interactions of Dendrimer Nanocomplexes 343

10.4 PotentialApplications of Dendrimer in Nanomedicine 347

10.5 Conclusion 353

Acknowledgements 355

Indexing words 355

References 355

11 Theranostic Nanoparticles for Cancer Imaging and Therapy 363
Mami Murakami, Mark J. Ernsting and Shyh-Dar Li

11.1 Introduction 363

11.2 Multifunctional Nanoparticles for Noninvasive

11.3 Multifunctional Nanoparticles for Monitoring Drug Release 375

11.4 Theranostics to Image Therapeutic Response 380

11.5 Conclusion and Future Directions 382

Acknowledgement 383

References 383

Part IV: Nanoscaffolds technology

12 Nanostructure Polymers in Function Generating Substitute and Organ Transplants 389
S.K. Shukla

12.1 Introduction 389

12.2 Important Nanopolymers 391

12.3 MedicalApplications 397

Acknowledgement 411

References 411

13 Electrospun Nanofiberfor Three Dimensional Cell Culture 417
Yashpal Sharma, Ashutosh Tiwari and Hisatoshi Kobayashi

13.1 Introduction 417

13.2 Nanofiber Scaffolds Fabrication Techniques 419

13.3 Parameters of Electrospinning Process 424

13.4 Electrospun Nanofibers for Three-dimensional Cell Culture 426

13.5 Conclusions 429

References 431

14 Magnetic Nanoparticles in Tissue Regeneration 435
Anuj Tripathi, Jose Savio Melo and Stanislaus Francis D'Souza

14.1 Introduction 435

14.2 Magnetic Nanoparticles: Physical Properties 438

14.3 Synthesis of Magnetic Nanoparticles 440

14.4 Design and Structure of Magnetic Nanoparticles 443

14.5 Stability and Functionalization of Magnetic Nanoparticles 445

14.6 Cellular Toxicity of Magnetic Nanoparticles 450

14.7 Tissue EngineeringApplications of Magnetic Nanoparticles 453

14.8 Challenges and Future Prospects 473

Acknowledgement 474

References 474

15 Core-sheath Fibersfor Regenerative Medicine 485
Rajesh Vasita and Fabrizio Gelain

15.1 Introduction 486

15.2 Core-sheath Nanofiber Technology 489

15.3Application of Core-sheath Nanofibers 504

15.4 Conclusions 519

References 519

Über Autor(innen)

Ashutosh Tiwari is an assistant professor of nanobioelectronics at the Biosensors and Bioelectronics Centre, IFM-Linköping University, Editor-in-Chief of Advanced Materials Letters, and a materials chemist. He graduated from the University of Allahabad, India. He has published more than 125 articles and patents as well as authored/edited in the field of materials science and technology. Dr.Tiwari received the 2011 "Innovation in Materials Science Award and Medal" during the International Conference on Chemistry for Mankind: Innovative Ideas in Life Sciences.

Atul Tiwari is an associate researcher at the Department of Mechanical Engineering in the University of Hawaii, USA. He received his PhD in Polymer Science and earned the Chartered Chemist and Chartered Scientist status from the Royal Society of Chemistry, UK. His areas of research interest include the development of silicones and graphene materials for various industrial applications. Dr. Tiwari has invented several international patents pending technologies that have been transferred to industries. He has been actively engaged in various fields of polymer science, engineering, and technology and has published more than fifty peer-reviewed journal papers, book chapters, and books related to material science.