Computer-Aided Vaccine Design

Erscheinungsjahr 2013
ISBN: 978-1-907568-41-1
Verlag: Woodhead Publishing

Buch, Englisch, 164 Seiten, Gewicht: 410 g

Computational pre-screening of antigens is now routinely applied to the discovery of vaccine candidates.Computer-aided vaccine design is a comprehensive introduction to this exciting field of study. The book is intended to be a textbook for researchers and for courses in bioinformatics, as well as a laboratory reference guide. It is written mainly for biologists who want to understand the current methods of computer-aided vaccine design. The contents are designed to help biologists appreciate the underlying concepts and algorithms used, as well as limitations of the methods and strategies for their use. Chapters include: MHC and T cell responses; Immunoglobulins and B cell responses; Scientific publications and databases; Database design; Computational T cell vaccine design; Computational B cell vaccine design; infectious disease informatics; Vaccine safety and quality assessments; and Vaccine adjuvant informatics.

Autoren/Hrsg.

Tong, Joo Chuan

Ranganathan, Shoba

Fachgebiete

• Naturwissenschaften Biowissenschaften Angewandte Biologie Bioinformatik
• Mathematik | Informatik EDV | Informatik Angewandte Informatik Bioinformatik

Inhaltsverzeichnis

List of figures

List of abbreviations

About the authors

Preface

Chapter 1: MHC and T cell responses

Abstract:

1.1 Genetic organization of the MHC

1.2 MHC structure

1.3 MHC function

1.4 Peptide binding

Chapter 2: Immunoglobulins and B cell responses

Abstract:

2.1 Types of immunoglobulins

2.2 Immunoglobulin structure

2.3 Immunoglobulin function

2.4 Antigen binding

Chapter 3: Scientific publications and databases

Abstract:

3.1 Bibliographical information

3.2 Searching the literature

3.3 General databases containing information on genes and proteins

3.4 Immunological databases

3.5 Small molecule databases

Chapter 4: Database design

Abstract:

4.1 Fundamentals of database design

4.2 ER diagram

4.3 Normalization and normal forms

Chapter 5: Computational T cell vaccine design

Abstract:

5.1 Sequence-based methods

5.2 Structure-based methods

5.3 Broad-based T cell vaccine design

Chapter 6: Computational B cell vaccine design

Abstract:

6.1 Sequence-based methods

6.2 Structure-based methods

Chapter 7: Infectious disease informatics

Abstract:

7.1 Infectious diseases in history

7.2 Microbial sequence analysis

7.3 Detecting natural selection in molecular evolution

Chapter 8: Vaccine safety and quality assessments

Abstract:

8.1 Assessment of ADME/Tox deficiencies

8.2 Assessment of allergenicity

Chapter 9: Vaccine adjuvant informatics

Abstract:

9.1 Virtual combinatorial library

9.2 Chemical file formats

9.3 Considerations for virtual library design

Index

Über Autor(innen)

Tong, Joo Chuan
Dr Joo Chuan Tong is a Senior Scientist at the A*STAR Institute of High Performance Computing, Singapore. He is an Adjunct Assistant Professor at the Department of Biochemistry, Yong Loo Lin School of Medicine, National University of Singapore. Dr. Tong has won numerous awards, including the MIT TR35 Award in 2008 and Singapore Youth Award (Science and Technology) in 2009, and is the only Asian on the Senior Innovation Advisory Board of Pfizer Inc, the world's largest research-based pharmaceutical company, at their world headquarters in New York, USA.

Dr Tong Joo Chuan is currently a Principal Investigator and Assistant Department Head of the Data Mining Department at A*STAR Institute for Infocomm Research, Singapore. He is also an Adjunct Assistant Professor at the Department of Biochemistry, Yong Loo Lin School of Medicine, National University of Singapore. Dr. Tong has won numerous awards, including the MIT TR35 Award in 2008 and Singapore Youth Award (Science and Technology) in 2009, and is the only Asian on the Senior Innovation Advisory Board of Pfizer Inc, the world's largest research-based pharmaceutical company, at their world headquarters in New York, USA. Current areas of research in the Tong group include: computational immunology, computational epigenetics, combinatorial library design and computational modeling of biological systems.

Professor Shoba Ranganathan is currently Chair Professor of Bioinformatics at Macquarie University, Australia. She is also Adjunct Professor at the National University of Singapore. Her research is focused on bioinformatics analysis at the genome, transcriptome and proteome levels. She holds a doctorate degree in Chemistry from the Indian Institute of Technology, Delhi, India, followed by post-doctoral training in biocomputing with Bernard Pullman and Alberte Pullman at the Institut de Biologie Physico-Chimique, Paris, France and at the University of New Orleans, USA. Her professional experience includes academic positions at the University of Delhi, India; University of Sydney, Australia; Australian National University and the National University of Singapore as well as Consultant to the first Australian bioinformatics company, eBioinformatics. She was the first Australian Director elected to the Board of the International Society for Computational Biology (ISCB) and is currently the President, Asia-Pacific Bioinformatics Network (APBionet) and Steering Committee member of the International Immunomics Society. Professor Ranganathan has authored more than 100 publications. She is an editorial board member and reviewer for several bioinformatics journals and has served on the organizing/program committees of several international conferences.