Fluorine and Health

Molecular Imaging, Biomedical Materials and Pharmaceuticals
Erscheinungsjahr 2008
ISBN: 978-0-444-53086-8
Verlag: Elsevier Science

Buch, Englisch, 816 Seiten, Format (B × H): 165 mm x 240 mm, Gewicht: 1650 g

Fluorine and Health presents a critical multidisciplinary overview on the contribution of fluorinated compounds to resolve the important global issue of medicinal monitoring and health care. The involved subjects are organized in three thematic parts devoted to Molecular Imaging, Biomedical Materials and Pharmaceuticals. Initially the key-position of partially fluorinated low molecular weight compounds labelled either with the natural 19F-isotope for Magnetic Resonance Imaging (MRI) or labelled with the radioactive [18F]-isotope for Positron Emission Tomography (PET) is highlighted. Both non-invasive methods belong to the most challenging in vivo imaging techniques in oncology, neurology and in cardiology for the diagnosis of diseases having the highest mortality in the industrialized countries. The manifold facets of fluorinated biomaterials range from inorganic ceramics to perfluorinated organic molecules. Liquid perfluorocarbons are suitable for oxygen transport and as potential respiratory gas carriers, while fluorinated polymers are connected to the pathology of blood vessels. Another important issue concerns the application of highly fluorinated liquids in ophthalmology. Moreover, fluorine is an essential trace element in bone mineral, dentine and tooth enamel and is applied for the prophylaxis and treatment of dental caries. The various origins of human exposure to fluoride species is detailed to promote a better understanding of the effect of fluoride species on living organisms.Medicinally relevant fluorinated molecules and their interactions with native proteins are the main focus of the third part. New molecules fluorinated in strategic position are crucial for the development of pharmaceuticals with desired action and optimal pharmacological profile. Among the hundreds of marketed active drug components there are more than 150 fluorinated compounds. The chapters will illustrate how the presence of fluorine atoms alters properties of bioactive compounds at various biochemical steps, and possibly facilitate its emergence as pharmaceuticals. Finally the synthetic potential of a fluorinase, the first C-F bond forming enzyme, is summarized.

Zielgruppe

Researchers in industry
Scientists in academia
Medical doctors
PhD students

Autoren/Hrsg.

Tressaud, Alain

Haufe, Gunter

Fachgebiete

• Medizin | Veterinärmedizin Medizin | Public Health | Pharmazie | Zahnmedizin Medizin, Gesundheitswesen Public Health, Gesundheitsmanagement, Gesundheitsökonomie, Gesundheitspolitik
• Medizin | Veterinärmedizin Medizin | Public Health | Pharmazie | Zahnmedizin Medizin, Gesundheitswesen Präventivmedizin, Gesundheitsförderung, Medizinisches Screening

Inhaltsverzeichnis

PART I: MOLECULAR IMAGING
1. Fluorine-18 Chemistry for Molecular Imaging with Positron Emission Tomography

Frédéric Dollé, Dirk Roeda, Bertrand Kuhnast, and Marie-Claire Lasne

2. Application of 18F-PET Imaging for the Study of Alzheimer's Disease

Kjell Någren and Juha O. Rinne

3. 18F-Labeled PET-Tracers for Cardiological Imaging

Klaus Kopka, Stefan Wagner, Michael Schäfers, Andreas Faust, Otmar Schober, and Günter Haufe

4. [18F]-Labeled PET and PET/CT Compounds in Oncology

Ken Herrmann and Bernd Joachim Krause

5. Non-Invasive Physiology and Pharmacology Using 19F Magnetic Resonance

Jian-Xin Yu, Weina Cui, Dawen Zhao, and Ralph P. Mason

PART II: BIOMEDICAL MATERIALS
6. Fluoride-Based Bioceramics

Christian Rey, Christèle Combes, Christophe Drouet, and Hocine Sfihi

7. Fluoride in Dentistry and Dental Restoratives

John W. Nicholson and Beata Czarnecka

8. Fluorinated Biomaterials for Cardiovascular Surgery

Charles Baquey, Marie-Christine Durrieu, and Robert G. Guidoin

9. Fluorinated Molecules in Eye Surgery: Experimental and Clinical Benefit of a Heavy Silicone Oil Oxane Hd® (Mixture of Silicone Oil and RMN3 Fluorine Olefin) in the Treatment of Retinal Detachment

I. Rico-Lattes, J. C. Quintyn, V. Pagot-Mathis, X. Benouaich, and A. Mathis

10. Biocompatibility of Highly Fluorinated Liquids Used in Ophthalmic Surgery

Dirk-Henning Menz and Joachim H. Dresp

11. Perfluorochemical-Based Oxygen Therapeutics, Contrast Agents, and Beyond

Marie Pierre Krafft and Jean G. Riess

12. Exposure of Humans to Fluorine and Its Assessment

Maja Ponikvar

PART III: PHARMACEUTICALS
13. Biological Impacts of Fluorination: Pharmaceuticals Based on Natural Products

Jean-Pierre Bégué and Danièle Bonnet-Delpon

14. Synthesis and Pharmacological Properties of Fluorinated Prostanoids

Yasushi Matsumura

15. Synthesis and Biochemical Evaluation of Fluorinated Monoamine Oxidase Inhibitors

Kenneth L. Kirk, Shinichi Yoshida, and Günter Haufe

16. Fluoroolefin Dipeptide Isosteres: Structure, Syntheses, and Applications

John T. Welch

17. Molecular Interactions of Fluorinated Amino Acids in a Native Polypeptide Environment

Mario Salwiczek, Christian Jäckel, and Beate Koksch

18. Biological Fluorination in Streptomyces cattleya: The Fluorinase

Hai Deng, Fang-Lu Huang, James H. Naismith, David O'Hagan, Jonathan B. Spencer, and Xiaofeng Zhu