Lysosomal Pathophysiology of Parkinson's Disease

Erscheinungsjahr 2026
ISBN: 978-0-443-24050-8
Verlag: Elsevier Science

Buch, Englisch, 300 Seiten, Format (B × H): 152 mm x 229 mm

Lysosomal Pathophysiology of Parkinson’s Disease delves into the genetic and genomic revelations that have transformed our understanding of Parkinson’s Disease at the molecular level. The book highlights the critical role of the autophagy-lysosome pathway in the disease's pathogenic processes, drawing a comprehensive timeline of disease onset and progression. It offers a detailed examination of how disruptions in this pathway contribute to the hallmarks of Parkinson’s Disease, providing invaluable insights for researchers and clinicians alike. Subsequent chapters extend these insights by comparing Parkinson’s Disease to other neurodegenerative disorders such as Alzheimer’s Disease and Frontotemporal Dementia.

By exploring protein pathology and synaptic alterations, the book underscores the broader implications of autophagy-lysosome dysfunction. Additionally, it discusses how the molecular perspectives gleaned from Parkinson’s Disease can inform our understanding of these other conditions, presenting a unified approach to studying neurodegeneration.

Autoren/Hrsg.

Volta, Mattia

Beccano-Kelly, Dayne

Fachgebiete

• Interdisziplinäres Wissenschaften Wissenschaften Interdisziplinär Neurowissenschaften, Kognitionswissenschaft
• Medizin | Veterinärmedizin Medizin | Public Health | Pharmazie | Zahnmedizin Klinische und Innere Medizin Neurologie, Klinische Neurowissenschaft

Inhaltsverzeichnis

Part 1: A molecular reappraisal of Parkinson’s disease
1. Clinical and neuropathological presentation of Parkinson’s disease
2. The genetic revolution: towards an etiology-based view
3. Neuronal processes involved in etiology
4. Non-neuronal mechanisms of disease
5. The autophagy-lysosome pathway as convergence point of pathogenesis

Part 2: Autophagy-Lysosome function in Parkinson’s pathophysiology
6. Molecular biology of the autophagy pathway
7. The functional roles of lysosomes
8. Physiology of lysosomes in the critical electrophysiological function of neurons
9. Lysosomes in Parkinson’s disease neuropathology
10. Lysosomal dysfunction in Parkinson’s disease etiology

Part 3: Therapeutic options targeting lysosome biology
11. Current therapies for PD
12. Targeting options in lysosome biology
13. Autophagy-Lysosome-based therapies in neurological disorders
14. An update on clinical trials for autophagy-lysosome therapies in Parkinson’s disease
15. Prospective targeting strategies and drug development

Part 4: Neurobiological commonalities with other neurodegenerative proteinopathies
16. The autophagy-lysosome pathway and overlaps with Alzheimer-like pathologies
17. The autophagy-lysosome pathway in other neurodegenerative diseases
18. Synaptic dysfunction in neurodegeneration
19. Towards a common pathophysiology scenario in neurodegenerative diseases?

Über Autor(innen)

Beccano-Kelly, Dayne
Dr. Beccano-Kelly is a UKRI Future Leader Fellow and expert on synaptic dysfunction in Parkinson's disease. With a degree in Biochemistry and over 17 years of neurodegenerative research experience, he has numerous publications in the field of electrophysiology, molecular mechanism in neurodegenerative conditions. His particular focus has been on Parkinson's, utilizing various models of the disease including induced pluripotent stem cells and murine models. Via assessment of late-onset disease causing mutations in critical genes (LRRK2, GBA, VPS35, DNAJC13) his target has been to recapitulate the insidious and progressive nature of Parkinson's disease in an effort to understand the pathophysiological timeline and identify ways in which to intervene with the disease process

Volta, Mattia
Dr. Volta is a Senior Researcher and Team Leader at Eurac Research, in Italy. He has worked in Parkinson's disease for his whole career, applying several complementary approaches in vitro and in vivo to better understand the causes of the disease and how to tackle them therapeutically. His current team has developed a strong focus on the investigation of the autophagy-lysosome pathway, assessing how it is affected by genes linked to Parkinson's and identifying novel molecular mechanisms that could underlie disease etiology. This mechanistic effort is aimed at nominating and validating novel, effective targets for neuroprotection.