B Cells in Immunity and Tolerance

1. Auflage 2020
ISBN: 978-981-15-3531-4
Verlag: Springer Nature Singapore

Buch, Englisch, Band 1254, 181 Seiten, Format (B × H): 183 mm x 260 mm, Gewicht: 576 g

Reihe: Advances in Experimental Medicine and Biology

This book contains twelve chapters contributed by prestigious international experts who are at the forefront of B cell research, and aims to provide a cutting-edge and comprehensive overview of all aspects of B cells, including B cell development, maturation and activation, germinal center reaction, memory and plasma cell differentiation, and antibody-mediated positive and negative regulation of humoral immune responses. There are also three chapters describing human diseases caused by B cell abnormalities, including primary antibody deficiencies, autoimmune diseases, and B cell malignancies. We hope that this book will become a standard and routine reference for both basic researchers and clinicians.

Zielgruppe

Research

Autoren/Hrsg.

Wang, Ji-Yang

Fachgebiete

• Medizin | Veterinärmedizin Medizin | Public Health | Pharmazie | Zahnmedizin Klinische und Innere Medizin Allergologie
• Medizin | Veterinärmedizin Medizin | Public Health | Pharmazie | Zahnmedizin Klinische und Innere Medizin Immunologie
• Medizin | Veterinärmedizin Medizin | Public Health | Pharmazie | Zahnmedizin Vorklinische Medizin: Grundlagenfächer Molekulare Medizin, Zellbiologie

Inhaltsverzeichnis

B cell development and maturation.- B cell receptor signalling.- Involvement of reactive oxygen species (ROS) in BCR signaling as a second messenger.- Germinal center reaction.- Memory B cells in local and systemic sites.- Regulation of plasma cell differentiation.- Regulation of humoral immune responses and B cell tolerance by the IgM Fc receptor.- Regulatory B cells.- Diversified IgA-bacteria interaction in gut homeostasis.- Primary antibody deficiencies.- B cell-mediated autoimmune diseases.- B cell lymphomas.

Über Autor(innen)

Dr. Ji-Yang Wang is a professor at Department of Immunology, School of Basic Medical Sciences, Fudan University, China. He was recruited to the 1000Talents Program of Shanghai in 2013. Prof. Wang’s research focuses on B cell development, activation and differentiation, and B cell-related diseases. He has published more than 100 articles on international journals in these fields.