Wiles / Watts Micro Reaction Technology in Organic Synthesis

1. Auflage 2011
ISBN: 978-1-4398-2472-6
Verlag: Taylor & Francis
Format: PDF
Kopierschutz: Adobe DRM (»Systemvoraussetzungen)

E-Book, Englisch, 453 Seiten

While continuous processes have found widespread application within chemical production, members of the research and development communities have historically favored the centuries old technique of iterative batch reactions. With the exception of combinatorial and microwave chemistry, little had been done to change the way that synthetic chemists conduct their research. However, today’s synthetic chemist is under increasing pressure to discover and deliver compounds quickly, with an eye on devising scalable synthetic methodologies.

An up-to-date account of recent developments in continuous flow organic synthesis, Micro Reaction Technology in Organic Synthesis is a useful resource for those both new to, and actively researching within, the field of micro reaction technology.

- Written by chemists for chemists, key synthetic information takes precedence over technological details

- Highlights the advantages and disadvantages of the technology, giving the reader an idea of where future research needs to be targeted

- Presents a comprehensive collection of synthetic reactions that have been investigated over the past decade, therefore is a one-stop resource to the reactions and techniques that have been investigated so far

With an ever increasing number of commercial flow reaction platforms available, this book highlights the current state of the technology with the vision that more synthetic chemists will embark upon flow chemistry programs of research, facilitating the identification of novel synthetic methodologies the potential to be scaled directly to production.

Zielgruppe

Organic chemists, researchers in the fine chemicals industry, formulation chemists, process chemists, chemical engineers, biochemists; and scientists in drug discovery, biotechnology, high performance materials, and composite materials.

Autoren/Hrsg.

Wiles, Charlotte

Watts, Paul

Fachgebiete

• Naturwissenschaften Chemie Physikalische Chemie
• Geowissenschaften Umweltwissenschaften Umwelttechnik
• Naturwissenschaften Chemie Organische Chemie
• Technische Wissenschaften Umwelttechnik | Umwelttechnologie Umwelttechnik
• Technische Wissenschaften Verfahrenstechnik | Chemieingenieurwesen | Biotechnologie Verfahrenstechnik, Chemieingenieurwesen
• Technische Wissenschaften Verfahrenstechnik | Chemieingenieurwesen | Biotechnologie Chemische Anlagen

Inhaltsverzeichnis

Introduction to Micro Reaction Technology
What is Micro Reaction Technology?
Fabrication/Construction of Micro Reactors
Manipulation of Reactants and Products within Flow Reactors
Advantages of Micro Reaction Technology
Disadvantages of Micro Reactors
Process Intensification
In Situ Reaction Monitoring
Commercial Availability of Continuous Flow
Outlook
References

Micro Reactions Employing a Gaseous Component
Gas-Phase Micro Reactions
Gas–Liquid-Phase Micro Reactions
Gas–Liquid–Solid Micro Reactions
References

Liquid-Phase Micro Reactions
Nucleophilic Substitution
Electrophilic Substitution
Nucleophilic Addition
Elimination Reactions
Oxidations
Reductions
Metal-Catalyzed Cross-Coupling Reactions
Rearrangements
Multistep/Multicomponent Liquid-Phase Reactions
Summary
References

Multi-Phase Micro Reactions
Nucleophilic Substitution
Electrophilic Substitution
Nucleophilic Addition
Elimination Reactions
Oxidation Reactions
Metal-Catalyzed Cross-Coupling Reactions
Rearrangements
Enantioselective Reactions
Multistep/Multicomponent Reactions
Summary
References

Electrochemical and Photochemical Applications of Micro Reaction Technology
Electrochemical Synthesis under Continuous Flow
Photochemical Synthesis under Continuous Flow
Multiphase Photochemical Reactions
References

The Use of Microfluidic Devices for the Preparation and Manipulation of Droplets and Inorganic/Organic Particles
Droplet Formation using Continuous Flow Methodology
Preparation of Inorganic Nanoparticles under Continuous Processing Conditions
Formation of Organic Particles within Continuous Flow Devices
The Use of Micro Reactors for the Postsynthetic Manipulation of Organic Compounds
Mixed Particle Formation
Summary
References

Industrial Interest in Micro Reaction Technology
MRT in Production Environments
Synthesis of Fine Chemicals Using Micro Reactors
Synthesis of Pharmaceuticals and Natural Products using Continuous Flow Methodology
Synthesis of Small Doses of Radiopharmaceuticals
Summary
References

Microscale Continuous Separations and Purifications
Introduction
Liquid–Liquid Extractions
Gas–Liquid Separation
Solvent Exchange and Solvent Removal
The Use of Scavenger Resins for Product Purification under Flow
Continuous Flow Resolutions
Product Isolation
Summary
References