Xu New Frontiers in Ultrasensitive Bioanalysis

Advanced Analytical Chemistry Applications in Nanobiotechnology, Single Molecule Detection, and Single Cell Analysis
1. Auflage 2007
ISBN: 978-0-470-11949-5
Verlag: John Wiley & Sons
Format: PDF
Kopierschutz: Adobe DRM (»Systemvoraussetzungen)

E-Book, Englisch, 328 Seiten, E-Book

Reihe: Chemical Analysis: A Series of Monographs on Analytical Chemistry and Its Applications

An overview of current research and developments inultrasensitive bioanalysis
New platforms of ultrasensitive analysis of biomolecules andsingle living cells using multiplexing, single nanoparticlesensing, nano-fluidics, and single-molecule detection are advancingevery scientific discipline at an unprecedented pace. With chapterswritten by a diverse group of scientists working in the forefrontof ultrasensitive bioanalysis, this book provides an overview ofthe current status and an in-depth understanding of the objectivesand future research directions of ultrasensitive bioanalysis.Spanning a wide spectrum of new research approaches, this book:
* Introduces new theories, ideas, methodologies, technologies,and applications of ultrasensitive bioanalysis in a wide variety ofresearch fields
* Includes background, fundamentals, and descriptions ofinstrumentation and techniques behind every experimental design andapproach to help readers explore the promising applications of newtools
* Covers single molecule detection (SMD), single living cellanalysis, multi-functional nanoparticle probes, miniaturization,multiplexing, quantitative and qualitative analysis of metal ionsand small molecules, and more
* Discusses techniques such as single molecule microscope andspectroscopy, single nanoparticle optics, single nanoparticlesensors, micro- and nano-fluidics, microarray detection,ultramicroelectrodes, electrochemiluminescence, mass spectrometry,and more
This book will be a useful resource and an inspiration forscientists and graduate and undergraduate students in a widevariety of research fields, including chemistry, biology,biomedical science and engineering, and materials science andengineering.

Autoren/Hrsg.

Xu, Xiao-Hong Nancy

Inhaltsverzeichnis

Preface.
Contributors.
Chapter 1. Is One Enough (Andrew C. Beveridge, James H. Jett,and Richard A. Keller)?
Chapter 2. Dissecting Cellular Activity from Single Genes toSingle mRNAs (Xavier Darzacq, Robert H. Singer, and YaronShav-Tal).
Chapter 3. Probing Membrane Transport of Single Live Cells UsingSingle Molecule Detection and Single Nanoparticle Assay (Xiao-HongNancy Xu, Yujun Song, and Prakash D. Nallathamby).
Chapter 4. Nanoparticle Probes for Ultrasensitive BiologicalDetection and Imaging (Amit Agrawal, Tushar Sathe, and ShumingNie).
Chapter 5. Tailoring Nanoparticles for the Recognition ofBiomacromolecule Surfaces (Mrinmoy De, Rochelle R. Arvizo, AyushVerma and Vincent M. Rotello).
Chapter 6. Nanoscale Chemical Analysis of Individual SubcellularCompartments (Gina S. Fiorini and Daniel T. Chiu).
Chapter 7. Ultra-sensitive Time-resolved Near-IR Fluorescencefor Multiplexed Bioanalysis (Li Zhu and Steven A. Soper).
Chapter 8. Ultra-Sensitive Microarray Detection of DNA usingEnzymatically Amplified SPR Imaging (Hye Jin Lee, Alastair W. Warkand Robert M. Corn).
Chapter 9. Ultrasensitive Analysis of Metal Ions and SmallMolecules in Living Cells (Richard B. Thompson).
Chapter 10. Electrochemistry Inside and Outside Single NerveCells (Daniel J. Eves and Andrew G. Ewing).
Chapter 11. New Bioanalytical Applications ofElectrochemiluminescence (Yanbing Zu and Xiao-Hong Nancy Xu).
Chapter 12. Single Cell Measurements with Mass Spectrometry(Eric B. Monroe, John C. Jurchen, Stanislav Rubakhin, and JonathanV. Sweedler).
Chapter 13. Outlooks of Ultrasensitive Detection in Bioanalysis(Xiao-Hong Nancy Xu).

Über Autor(innen)

Xiao-Hong Nancy Xu, PHD, is a tenured Associate Professor of Chemistry and Biochemistry at Old Dominion University in Norfolk, Virginia. Her current research program focuses on the development and application of cutting-edge bionanotechnologies and ultrasensitive analytical and sensing methodologies to address fundamental and practical questions in chemical, biochemical, and biomedical sciences and engineering, and is supported by NSF, NIH, DoE, and DoD. She has served extensively as a peer-reviewer for an array of journals and panels and an invited organizer of symposia in chemistry and bioengineering at national and international conferences.