Yan Analysis and Purification Methods in Combinatorial Chemistry

1. Auflage 2004
ISBN: 978-0-471-53199-9
Verlag: John Wiley & Sons
Format: PDF
Kopierschutz: Adobe DRM (»Systemvoraussetzungen)

E-Book, Englisch, 480 Seiten, E-Book

Reihe: Chemical Analysis: A Series of Monographs on Analytical Chemistry and Its Applications

Quality measurement, control, and improvement in combinatorialchemistry
Combinatorial chemistry has developed rapidly in the past decade,with great advances made by scientists working on analysis andpurification of a large number of compounds and the analysis ofpolymer-bound compounds. However, formidable challenges lie aheadof today's researcher. For example, high-throughput analysis andpurification technologies must be further developed to ensurecombinatorial libraries are "purifiable," and "drugable."
To this end, Analysis and Purification Methods in CombinatorialChemistry describes various analytical techniques and systems forthe development, validation, quality control, purification, andphysicochemical testing of combinatorial libraries. A new volume inWiley's Chemical Analysis series, this text has four partscovering:
* Various approaches to monitoring reactions on solid support andoptimizing reactions for library synthesis
* High-throughput analytical methods used to analyze the quality oflibraries
* High-throughput purification techniques
* Analytical methods applied in post-synthesis andpost-purification stages
Drawing from the contributions of respected experts incombinatorial chemistry, this comprehensive book provides coverageof applications of Nuclear Magnetic Resonance (NMR), liquidchromatography/mass spectrometry (LC/MS), Fourier TransformInfrared (FTIR), micellar electrokinetic chromatography (MEKC)technologies, as well as other analytical techniques.
This eminently useful volume is an essential addition to thelibrary of students and researchers studying or working inanalytical chemistry, combinatorial chemistry, medicinal chemistry,organic chemistry, biotechnology, biochemistry, or biophysics.

Autoren/Hrsg.

Yan, Bing

Inhaltsverzeichnis

Preface.
Contributors.
PART I: ANALYSIS FOR FEASIBILITY AND OPTIMIZATION OF LIBRARYSYNTHESIS.
Chapter 1. Quantitative Analysis in Organic Synthesis with NMR(L. Lucas & C. Larive).
Chapter 2. ¯19F Gel-phase NMR Spectroscopy forReaction Monitoring and Quantification of Resin Loading (J.Salvino).
Chapter 3. The Application of Single-Bead FTIR and Color Testfor Reaction Monitoring and Building Block Validation inCombinatorial Library Sysnthesis(J. Cournoyer, et al.).
Chapter 4. HR-MAS NMR Analysis of Compounds Attached to PolymerSupports (M. Guinó & Y. de Miguel).
Chapter 5. Multivariate Tools for Real-Time Monitoring andOptimization of Combinatorial Materials and ProcessConditions (R. Potyrailo, et al.).
Chapter 6. Mass Spectrometry and Soluble Polymeric Supports (C.Enjalbal, et al.).
PART II: HIGH-THROUGHPUT ANALYSIS FOR LIBRARY QUALITYCONTROL.
Chapter 7. High-Throughput NMR Techniques for CombinatorialChemical Library Analysis (T. Hou & D. Raftery).
Chapter 8. Micellar Electrokinetic Chromatography as a Tool forCombinatorial Chemistry Analysis: Theory and Applications (P.Simms).
Chapter 9. Characterization of Split-Pool Encoded CombinatorialLibraries (J. Zhang & W. Fitch).
PART III: HIGH-THROUGHPUT PURIFICATION TO IMPROVE LIBRARYQUALITY.
Cha pter 10. Strategies and Methods for Purifying OrganicCompounds and Combinatorial Libraries (J. Zhao, et al.).
Chapter 11. HTP of Combinatorial Chemistry Libraries (J.Hochlowski).
Chapter 12. Practical HPLC in High Throughput Analysis andPurification (H. Gumm & R. God).
PART IV: ANALYSIS FOR COMPOUND STABILITY AND DRUGABILITY.
Chapter 13. Organic Compound Stability in Large, DiversePhatmaceutical Screening Collection (K. Morand & X. Cheng).
Chapter 14. Quartz Crystal Microbalance in BiomolecularRecognition (M. Tseng, et al.).
Chapter 15. High-Throughput Physicochemical Profiling: Potentialand Limitations (B. Faller).
Chapter 16. Solubility in the Design of Combinatorial Libraries(C. Lipinski).
Chapter 17. High-Throughput Determination of Log D Valuesby LC/MS Method (J. Villena, et al.).
Index.

Über Autor(innen)

BING YAN, PhD, was born in China and received his PhD inchemistry at Columbia University in 1990. He then worked at CambridgeUniversity and the University of Texas-Houston Medical School as a postdoctoralfellow. From 1993 to 1999, he worked for Novartis in the Core Technologies areaof preclinical research in New Jersey. He is currently at the DiscoveryChemistry division of Discovery Partners International, Inc., in San Francisco.His major research interests are drug discovery, optimization of solid-phaseand solution-phase combinatorial synthesis, high-throughput quantitative andqualitative analysis, and high-throughput purification of combinatoriallibraries. He has written four books and published over seventy reviews andresearch articles.