Yang Bioprocessing for Value-Added Products from Renewable Resources

New Technologies and Applications
1. Auflage 2011
ISBN: 978-0-08-046671-2
Verlag: Elsevier Science & Techn.
Format: EPUB
Kopierschutz: 6 - ePub Watermark

E-Book, Englisch, 684 Seiten

Bioprocessing for Value-Added Products from Renewable Resources provides a timely review of new and unconventional techniques for manufacturing high-value products based on simple biological material. The book discusses the principles underpinning modern industrial biotechnology and describes a unique collection of novel bioprocesses for a sustainable future. This book begins in a very structured way. It first looks at the modern technologies that form the basis for creating a bio-based industry before describing the various organisms that are suitable for bioprocessing - from bacteria to algae - as well as their unique characteristics. This is followed by a discussion of novel, experimental bioprocesses, such as the production of medicinal chemicals, the production of chiral compounds and the design of biofuel cells. The book concludes with examples where biological, renewable resources become an important feedstock for large-scale industrial production. This book is suitable for researchers, practitioners, students, and consultants in the bioprocess and biotechnology fields, and for others who are interested in biotechnology, engineering, industrial microbiology and chemical engineering.?Reviews the principles underpinning modern industrial biotechnology
?Provides a unique collection of novel bioprocesses for a sustainable future
?Gives examples of economical use of renewable resources as feedstocks
?Suitable for both non-experts and experts in the bioproduct industry

Autoren/Hrsg.

Yang, Shang-Tian

Inhaltsverzeichnis

1;Bioprocessing For Value-Added Products From Renewable Resources;4
2;Copyright Page;5
3;Table of Contents;6
4;List of contributors;10
5;Preface;14
6;Chapter 1. Bioprocessing – from Biotechnology to Biorefinery;16
6.1;1. Introduction;16
6.2;2. Industrial biotechnology – History and applications;16
6.3;3. Bioprocessing – Current status and development;21
6.4;4. Biomass feedstocks;24
6.5;5. Biorefineries;29
6.6;6. Summary and outlook;35
6.7;Acknowledgements;36
6.8;References;36
7;Part I. Enabling Technologies;40
7.1;Chapter 2. Application of Genomic and Proteomic Data for Bioprocess Analysis and Optimization;40
7.1.1;1. Introduction;40
7.1.2;2. Applications of genomic and proteomic analyses;41
7.1.3;3. Bioprocess analysis and optimization guided by genomic and proteomic analyses: The example of microbial production of 1,3-propanediol;49
7.1.4;4. Concluding remarks and outlook;58
7.1.5;References;59
7.2;Chapter 3. Directed Evolution Tools in Bioproduct and Bioprocess Development;64
7.2.1;1. Introduction;64
7.2.2;2. Directed evolution tools for diversity generation;65
7.2.3;3. Applications of directed evolution tools;79
7.2.4;4. Alternatives to directed evolution;82
7.2.5;5. Conclusion;84
7.2.6;Acknowledgements;84
7.2.7;References;84
7.3;Chapter 4. Metabolic Engineering – Applications, Methods, and Challenges;88
7.3.1;1. Introduction;88
7.3.2;2. Applications and some examples;89
7.3.3;3. Metabolic engineering strategies and limitations;109
7.3.4;4. Metabolic engineering methodologies and tools;111
7.3.5;5. Challenges and new approaches for metabolic engineering;117
7.3.6;6. Summary;121
7.3.7;References;122
7.4;Chapter 5. Amylase and Cellulase Structure and Function;134
7.4.1;1. Introduction;134
7.4.2;2. Amylase and cellulase classification and mechanisms;136
7.4.3;3. Conclusions;144
7.4.4;Acknowledgment;144
7.4.5;References;144
7.5;Chapter 6. Bioreactor Engineering;146
7.5.1;1. Introduction;146
7.5.2;2. Various types of bioreactors;148
7.5.3;3. Effects of process parameters on biological performances;157
7.5.4;4. Industrial applications of bioreactors;164
7.5.5;5. Trends in bioreactor engineering;167
7.5.6;Acknowledgments;171
7.5.7;References;171
7.6;Chapter 7. Membranes for Bioseparations;178
7.6.1;1. Introduction;178
7.6.2;2. Membranes in bioseparations;178
7.6.3;3. Microfiltration and ultrafiltration processes;180
7.6.4;4. Membrane fouling;182
7.6.5;5. Applications in biotechnology industries;194
7.6.6;5.3. Other applications;196
7.6.7;6. Outlook;197
7.6.8;References;197
8;Part II. Cultures for Bioprocessing;200
8.1;Chapter 8. Bacterial and Yeast Cultures – Process Characteristics, Products, and Applications;200
8.1.1;1. Introduction;200
8.1.2;2. Bacteria;201
8.1.3;3. Yeast;207
8.1.4;4. Fermentation products from bacteria and yeasts;209
8.1.5;5. Fermentation processes;218
8.1.6;6. Conlusion and outlook;228
8.1.7;References;229
8.2;Chapter 9. Filamentous Fungal Cultures – Process Characteristics, Products, and Applications;240
8.2.1;1. Introduction;240
8.2.2;2. Fungal cells as biofactories;241
8.2.3;3. Hyphal growth and protein secretion;243
8.2.4;4. Fungal growth in submerged culture;246
8.2.5;5. Effects of cultivation conditions;261
8.2.6;6. Effects of morphology on production and secretion;266
8.2.7;7. Immobilized fungal cells;270
8.2.8;8. Future of filamentous fungal cells as biofactories;271
8.2.9;References;271
8.3;Chapter 10. Plant Cell and Hairy Root Cultures – Process Characteristics, Products, and Applications;278
8.3.1;1. Introduction;278
8.3.2;2. Production of macromolecules;279
8.3.3;3. Production of small molecules;290
8.3.4;Acknowledgements;299
8.3.5;References;299
8.4;Chapter 11. Production of High-Value Products by Marine Microalgae Thraustochytrids;308
8.4.1;1. Introduction;308
8.4.2;2. Modes of microalgal cultivation;309
8.4.3;3. Thraustochytrids;310
8.4.4;4. High-value products from thraustochytrids;313
8.4.5;5. Other applications of thraustochytrids;330
8.4.6;6. Utilization of renewable resources;332
8.4.7;7. Safety issues;332
8.4.8;8. Conclusions;333
8.4.9;7 References;334
9;Part III. Unconventional and Novel Bioprocesses;340
9.1;Chapter 12. Nonconventional Biocatalysis for Production of Chemicals and Polymers from Biomass;340
9.1.1;1. Introduction;340
9.1.2;2. Enzymatic treatment of biomass components;341
9.1.3;3. Further processing of simple renewable molecules for value-added products;344
9.1.4;4. New trends in enzymatic bioprocessing;351
9.1.5;5. Summary;359
9.1.6;References;359
9.2;Chapter 13. Biocatalysis for Chiral Synthesis;366
9.2.1;1. Introduction;366
9.2.2;2. Chiral synthons by fermentation;366
9.2.3;3. Chiral molecules from hydrolase;370
9.2.4;4. Chiral molecules from enzymes requiring cofactors;373
9.2.5;5. Improving enantioselectivity by reaction engineering;376
9.2.6;6. Improving chiral synthesis by directed evolution and metabolic engineering;379
9.2.7;7. Conclusions;383
9.2.8;References;384
9.3;Chapter 14. Immobilized Cell Fermentation for Production of Chemicals and Fuels;388
9.3.1;1. Introduction;388
9.3.2;2. Immobilization techniques;389
9.3.3;3. Effects of cell immobilization;395
9.3.4;4. Immobilized cell bioreactors;398
9.3.5;5. Applications of immobilized cell technology;401
9.3.6;6. Conclusion;405
9.3.7;References;406
9.4;Chapter 15. Water-in-Oil Cultivation Technology for Viscous Xanthan Gum Fermentation;412
9.4.1;1. Introduction;412
9.4.2;2. Xanthan fermentations;412
9.4.3;3. New process development;413
9.4.4;4. Water-in-oil cultivation technology;415
9.4.5;5. PH-sensitive surfactants for water-in-oil cultivation;426
9.4.6;6. Conclusions;432
9.4.7;References;432
9.5;Chapter 16. Extractive Fermentation for the Production of Carboxylic Acids;436
9.5.1;1. Introduction;436
9.5.2;2. Carboxylic acid fermentation;439
9.5.3;3. Integrated fermentation-separation processes;448
9.5.4;4. Summary and outlook;455
9.5.5;References;456
9.6;Chapter 17. Fungal Fermentation for Medicinal Products;462
9.6.1;1. Introduction;462
9.6.2;2. Fungal physiology;462
9.6.3;3. Fungal metabolites;463
9.6.4;4. Pathway manipulation;469
9.6.5;5. Conclusions;475
9.6.6;References;475
9.7;Chapter 18. Solid State Fermentation and Its Applications;480
9.7.1;1. Introduction;480
9.7.2;2. Products from solid state fermentation (SSF);480
9.7.3;3. Advantages and unsolved problems;487
9.7.4;4. SSF reactors;489
9.7.5;5. Conclusions;498
9.7.6;Acknowledgements;499
9.7.7;Nomenclature;499
9.7.8;References;500
9.8;Chapter 19. Algal Photobioreactor for Production of Lutein and Zeaxanthin;506
9.8.1;1. Introduction;506
9.8.2;2. Classification of closed algal photobioreactors;507
9.8.3;3. Design challenges for closed algal photobioreactors;509
9.8.4;4. Overcoming challenges for lutein/zeaxanthin production;512
9.8.5;5. Conclusions;519
9.8.6;References;519
9.9;Chapter 20. Power-Generation from Biorenewable Resources: Biocatalysis in Biofuel Cells;522
9.9.1;1. Introduction;522
9.9.2;2. Role of biocatalysts in biofuel cells;523
9.9.3;3. Fuel options in biofuel cells;525
9.9.4;4. Biocatalysis in cathode reactions;528
9.9.5;5. Electron transfer in biofuel cells;529
9.9.6;6. Immobilization of biocatalysts and mediators;531
9.9.7;7. Engineering aspects of biofuel cells;533
9.9.8;8. Overall performance of biofuel cells;535
9.9.9;9. Conclusion;537
9.9.10;References;537
9.10;Chapter 21. Biological Production of Hydrogen from Renewable Resources;542
9.10.1;1. Introduction;542
9.10.2;2. Principles of biohydrogen production systems;543
9.10.3;3. Microorganisms and enzymes for hydrogen production;547
9.10.4;4. Comparative studies on biohydrogen production processes;549
9.10.5;5. Improvements of photobiological hydrogen production;550
9.10.6;6. Improvements of fermentative hydrogen production;558
9.10.7;7. New concepts and strategies for biohydrogen production;566
9.10.8;8. Conclusion;568
9.10.9;References;568
10;Part IV. Feedstock Utilization;574
10.1;Chapter 22. Bioconversion of Whey Lactose into Microbial Exopolysaccharides;574
10.1.1;1. Introduction;574
10.1.2;2. Whey lactose;574
10.1.3;3. Microbial exopolysaccharides (EPS);577
10.1.4;4. Biosynthesis of EPS via lactose fermentation;589
10.1.5;5. Future outlook;593
10.1.6;6. Concluding remarks;594
10.1.7;Acknowledgement;594
10.1.8;References;594
10.2;Chapter 23. Microbial Production of Bioplastics from Renewable Resources;600
10.2.1;1. Introduction;600
10.2.2;2. Polyhydroxyalkanoates (PHAs);602
10.2.3;3. Microbial PHA fermentation;607
10.2.4;4. Integrated bioprocessing of renewable feedstock to PHA;613
10.2.5;5. PHA recovery;615
10.2.6;6. PHA economic analysis;618
10.2.7;7. Conclusions;621
10.2.8;Acknowledgement;622
10.2.9;References;622
10.3;Chapter 24. Industrial Applications for Plant Oils and Lipids;626
10.3.1;1. Introduction;626
10.3.2;2. Chemical composition of plant lipids;628
10.3.3;3. Chemical modifications of fats and fatty acids;632
10.3.4;4. Industrial applications and technology;633
10.3.5;5. Issues for industrial applications of plant lipids;640
10.3.6;References;641
10.4;Chapter 25. Value-Added Products from Animal Manure;644
10.4.1;1. Introduction;644
10.4.2;2. Characterization of animal manure;645
10.4.3;3. Production of reducing sugars from cattle manure lignocellulosics;650
10.4.4;4. Cellulolytic enzyme production from dairy manure;656
10.4.5;5. Summary;664
10.4.6;References;664
11;Index;668