Yang DNA Repair and Replication

1. Auflage 2004
ISBN: 978-0-08-052242-5
Verlag: Elsevier Science & Techn.
Format: PDF
Kopierschutz: 1 - PDF Watermark

E-Book, Englisch, 368 Seiten, Web PDF

DNA Repair and Replication contains an up-to-date review of general principles of DNA replication and an overview of the multiple pathways involved in DNA repair. Specific DNA repair pathways, including base-excision repair, light-dependent direct reversal of UV-damage, nucleotide-excision repair, transcription-coupled repair, double-strand break repair, and mismatch repair, are each discussed in separate chapters.
Selected Contents:
-Base Excision Repair
-Eukaryotic DNA Mismatch Repair
-Double Strand Break Repair
-Functions of DNA Polymerases
-Somatic Hypermutation: A Mutational Panacea

Autoren/Hrsg.

Yang, Wei

Inhaltsverzeichnis

1;Cover;1
2;DNA Repair and Replication;4
3;Copyright Page;5
4;CONTENTS;6
5;PREFACE;10
6;Chapter 1. Base Excision Repair;13
6.1;I. Introduction;13
6.2;II. Types of Damage Repaired by BER;17
6.3;III. DNA Glycosylases;19
6.4;IV. Downstream BER Enzymes;30
6.5;V. Mammalian BER;35
6.6;VI. Roles of BER Enzymes in Other Processes;39
6.7;References;40
7;Chapter 2. Nucleotide Excision Repair in E. Coli and Man;55
7.1;I. Introduction;55
7.2;II. Damage Recognition;57
7.3;III. Mechanism of Excision Repair;60
7.4;IV. Transcription-Coupled Repair;68
7.5;V. Repair of Chromatin;71
7.6;VI. Conclusion;75
7.7;References;77
8;Chapter 3. Photolyase and Cryptochrome Blue-Light Photoreceptors;85
8.1;I. Introduction;85
8.2;II. Phylogenetics;86
8.3;III. Structure of Photolyase;89
8.4;IV. Reaction Mechanism of Photolyase;91
8.5;V. (6–4) Photolyase;98
8.6;VI. Cryptochrome;102
8.7;VII. Conclusion;108
8.8;References;108
9;Chapter 4. Coordination of Repair, Checkpoint, and Cell Death Responses to DNA Damage;113
9.1;I. Introduction;113
9.2;II. Overview of Biological Responses to DNA Damage;116
9.3;III. Molecular Components for the Initiation of DNA Damage Responses;121
9.4;IV. Apoptotic Effectors in DNA Damage Response;127
9.5;V. DNA Repair Proteins in Damage Signaling;132
9.6;VI. Alternative Models for the Temporal Coordination of DNA Damage Responses;135
9.7;VII. Future Prospects;139
9.8;References;140
10;Chapter 5. Functions of DNA Polymerases;149
10.1;I. DNA Polymerase Families;149
10.2;II. Structures and Compositions of DNA Polymerases;151
10.3;III. Functions of DNA Polymerases;153
10.4;IV. Polymerases for DNA Repair;153
10.5;V. Polymerases for Replicating Undamaged DNA;162
10.6;VI. Polymerases for Sister Chromatid Cohesion;163
10.7;VII. Mitochondrial DNA Replication.;164
10.8;VIII. Polymerases for Replicating Damaged DNA.;164
10.9;IX. Polymerases and Cell-Cycle Checkpoints;167
10.10;X. Polymerases for Replication Restart and Homologous Recombination;167
10.11;XI. Polymerases for DNA Mismatch Repair;168
10.12;XII. Polymerases in the Development of the Immune System;168
10.13;XIII. Biological Consequences of Polymerase Dysfunction;169
10.14;XIV. Closing Comments;170
10.15;References;171
11;Chapter 6. Cellular Functions of DNA Polymerase and Rev1 Protein;179
11.1;I. Introduction;179
11.2;II. Enzymological Studies With Pol. and Rev1p;184
11.3;III. Genetic Analysis;190
11.4;IV. Processes Other than General Translesion Replication that Employ Pol and Rev1p;194
11.5;V. Regulation of Pol. and Rev1p and Interactions with other Proteins ;198
11.6;VI. Conclusions and Speculations;202
11.7;References;207
12;Chapter 7. DNA Polymerases. and .;217
12.1;I. Historical Perspective;217
12.2;II. Identification of RAD30 and its Orthologs;218
12.3;III. Biochemical Properties of Pol. and Pol.;219
12.4;IV. Translesion Synthesis by Pol. and Pol.;222
12.5;V. Structure of the Catalytic Core of S. cerevisiae Pol.;224
12.6;VI. Regulation and Localization of Pol. and Pol.;227
12.7;VII. Mutations in Polc. in XP Variants;229
12.8;VIII. Pols. and . and the Polymerase Switch: Interactions with PCNA and Rev1;231
12.9;IX. Protection from Cellular Effects of DNA Damage;232
12.10;X. Roles of Pol. and Pol. in Somatic Hypermutation;233
12.11;References;234
13;Chapter 8. Properties and Functions of Escherichia Coli : Pol IV and Pol V;241
13.1;I. DNA Pol IV, the dinB Gene Product;242
13.2;II. DNA Polymerase V, the umuDC Gene Product;260
13.3;References;269
14;Chapter 9. Mammalian Pol .: Regulation of Its Expression and Lesion Substrates;277
14.1;I. Structures of the Genes and Proteins;277
14.2;II. Enzymatic Properties of Pol.;283
14.3;III. Possible Mechanisms of TLS by Pol. In Vivo;286
14.4;References;287
15;Chapter 10. DNA Postreplication Repair Modulated by Ubiquitination and Sumoylation;291
15.1;I. Introduction;291
15.2;II. DNA Postreplication Repair Prokaryotes;292
15.3;III. DNA Postreplication Repair in Eukaryotes;293
15.4;IV. Ubiquitination;295
15.5;V. Protein Conjugation in PRR;298
15.6;VI. Postreplication Repair via Covalent Modifications of PCNA;304
15.7;VII. Functional Conservation of Eukaryotic Postreplication Repair;307
15.8;VIII. Future Directions;309
15.9;IX. Conclusions;312
15.10;References;313
16;Chapter 11. Somatic Hypermutation: A Mutational Panacea;319
16.1;I. Generation of Antibody Diversity;319
16.2;II. Somatic Hypermutation;325
16.3;III. Apobec Protein Family;335
16.4;IV. Biochemical Perspective;338
16.5;References;339
17;Author Index;349
18;Subject Index;381