Yevdokimov / Salyanov / Skuridin Nanostructures and Nanoconstructions based on DNA

Erscheinungsjahr 2012
ISBN: 978-1-4665-0570-4
Verlag: Taylor & Francis
Format: PDF
Kopierschutz: Adobe DRM (»Systemvoraussetzungen)

E-Book, Englisch, 250 Seiten

Reihe: Liquid Crystals Book Series

Evolutionally optimized biomolecules and their complexes present attractive objects in the production of functionalized nanoobjects. Indeed, nucleic acid-based molecules are primary candidates as building blocks for development of nanoscale systems and devices.

Written for chemists, physicists, molecular biologists, and students in related fields, Nanostructures and Nanoconstructions Based on DNA covers specific properties of metallic nanoparticles, and compares their properties with those related to nanoobjects formed by biological molecules. It also discloses details of formation and physicochemical peculiarities of the DNA nanostructures and DNA-based nanoconstructions. Furthermore, the book considers:

- The peculiarities of two approaches to structural DNA nanotechnology, i.e. to creation of spatial nanoobjects formed by DNA molecules and their complexes: (i) the hybridization approach and (ii) the liquid-crystalline approach

- The physicochemical properties of DNA nanostructures as well as "liquid" and "rigid" DNA-based nanoconstructions

- The connection of liquid crystalline phase formation in DNA with possible nanotechnological applications

This timely reference covers more DNA physics and molecular biology than any other published title. The authors discuss how nucleic acid molecules and their complexes with chemical and biologically active compounds are an area of increasing significance in the development of various nanoscale systems and devices of practical importance.

Autoren/Hrsg.

Yevdokimov, Yuri M.

Salyanov, V.I.

Skuridin, S.G.

Fachgebiete

• Naturwissenschaften Biowissenschaften Biowissenschaften DNA und Transgene Organismen
• Technische Wissenschaften Technik Allgemein Nanotechnologie
• Naturwissenschaften Biowissenschaften Angewandte Biologie Biophysik
• Technische Wissenschaften Verfahrenstechnik | Chemieingenieurwesen | Biotechnologie Biotechnologie Biotechnologie: Mikrotechnologie, Nanobiotechnologie
• Naturwissenschaften Biowissenschaften Molekularbiologie
• Naturwissenschaften Physik Angewandte Physik Biophysik

Inhaltsverzeichnis

Nanoparticles and Biological Molecules
Metal Nanoparticles and Their Properties
Biological Molecules: A New Background for the Creation of Nanoobjects
Organization of Research in Nanotechnology Area
The Health Risk of Nanomaterials
Nanostructures Formed by Hybridization of Synthetic Single- Stranded DNA Molecules
General Concept of the Fundamental Properties of DNA Used in Nanotechnology
Hybridization Technique of Creating Nanostructures Based on Synthetic Single-Stranded DNA Molecules (Bottom-Up Approach to the Creation of DNA Nanostructures)
Organic Linker Molecules as Rigid "Vertices" in the Tailored Spatial DNA Nanostructures Formed by Hybridization Technique
Arrangement of Objects on the Surface of DNA Nanostructures
"Liquid" Nanoconstructions Based on Spatially Ordered Double-Stranded DNA Molecules
Double-Stranded DNA Molecules as Building Blocks for Nanotechnology
Phase Exclusion of Double-Stranded DNA Molecules from Polyethylene Glycol Solutions
The Cholesteric Mode of Nucleic Acid Molecules Packing in Particles of Dispersions Results in an Appearance of Abnormal CD Spectra
Accumulation of the "Guest" Molecules in the DNA Molecules Forming CLCD Particles
"Rigid" Nanoconstructions Based by Spatially Ordered Double-Stranded DNA Molecules Complexed with Various Compounds and Nanoparticles
Backgrounds for Formation of Rigid DNA Nanoconstructions
Rigid Nanoconstructions Formed as a Result of Formation of Nanobridges between Neighboring DNA Molecules Fixed in Quasinematic Layers
The Magnetometric Evaluation of Cu2+ Ions in the Content of Nanobridges Formed between Spatially Fixed DNA Molecules
Visualization of Rigid DNA Nanoconstructions Linked with Nanobridges and Manipulations with These Nanoconstructions
Dependence of Optical Properties of DNA Nanoconstructions on Temperature
Rigid Nanoconstruction Formed as a Result of Formation of Complexes of DNA Molecules Fixed in Quasinematic Layers with Rare-Earth Metal Cations
Visualization of Rigid Particles of Cholesteric Liquid-Crystalline Dispersion of a [DNA-Gd3+] Complex
Au Nanoparticles Can Induce Formation of Rigid DNA Nanoconstruction
An Additional Case: Formation of Semi-Rigid Liquid-Crystalline Particles
Viral Particles as "Rigid" Biological Nanoconstructions: Their Creation and Medical Application Prospects
D. Yu. Logunov, B. S. Naroditsky, and A. L. Gintsburg
A "PEG-Like Situation" in Biological Systems and Peculiarities of Biological Nanoconstructions
Methods for Obtaining Recombinant Adenovirus "Rigid" Nanostructures
Recombinant Adenovirus Nanostructures with a Modified Genome
Replication-Competent Recombinant Adenovirus Nanostructures
Replication-Incompetent Recombinant Adenovirus Nanostructures
Capsid-Modified Recombinant Adenovirus Nanostructures
Physicochemical Modifications of Recombinant Adenovirus Particles
Application of Recombinant Adenovirus Nanostructures in Medicine
Application of "Liquid" and "Rigid" DNA Nanoconstructions Immobilized in Polymeric Hydrogel as Sensing Units
Issues of Stabilization of Particles of Liquid-Crystalline Dispersions
Immobilization of DNA LCD Particles in a Hydrogel
Formation and Immobilization of DNA Nanoconstruction in a Hydrogel

Über Autor(innen)

Chemists, physicists, molecular biologists, and other scientists and students of related fields.