Yuriev / Ramsland Structural Glycobiology

Erscheinungsjahr 2013
ISBN: 978-1-4398-5412-9
Verlag: Taylor & Francis
Format: PDF
Kopierschutz: Adobe DRM (»Systemvoraussetzungen)

E-Book, Englisch, 347 Seiten

Structural Glycobiology covers the experimental, theoretical, and alternative technologies used in the study of the structural basis for the diverse biological roles of carbohydrates. The book overviews the application of specialized technologies to the study of carbohydrates in biology, reviews relevant and current research in the field, and is illustrated throughout by specific examples of how research investigations have yielded key structural and associated biological data on carbohydrates and glycolipids. In particular, the book focuses on:

- X-ray crystallography and small-angle scattering, NMR, and cryo-electron microscopy techniques

- Theoretical (modeling-based) approaches, such as molecular mechanics, molecular dynamics, free energy calculations, and carbohydrate docking

- Alternative techniques for yielding structural information on carbohydrates from complex biological samples

- Carbohydrates in medicine, specifically in areas that have been directly impacted by our understanding of the structural role of carbohydrates in immune recognition: cancer, organ transplantation, and infection

Zielgruppe

Research scientists and graduate and postgraduate students with an interest in basic research and applied applications of structural glycobiology.

Autoren/Hrsg.

Yuriev, Elizabeth

Ramsland, Paul A.

Fachgebiete

• Naturwissenschaften Biowissenschaften Molekularbiologie
• Naturwissenschaften Biowissenschaften Proteinforschung
• Naturwissenschaften Chemie Chemie Allgemein Pharmazeutische Chemie, Medizinische Chemie
• Naturwissenschaften Biowissenschaften Kohlenhydrate

Inhaltsverzeichnis

Experimental Techniques to Determine Three-Dimensional Structures
Crystallography and Small-Angle Scattering of Carbohydrate–Protein Complexes and Glycoproteins
Cy M. Jeffries, William Farrugia, and Paul A. Ramsland
Nuclear Magnetic Resonance Studies of Carbohydrate–Protein Interactions
Leonardus M. I. Koharudin and Angela M. Gronenborn
Electron Cryomicroscopy of Large Glycoprotein Assemblies
Tzviya Zeev-Ben-Mordehai and Kay Grünewald

Theoretical/Modeling Techniques to Predict Three-Dimensional Structures
Protein–Carbohydrate Interactions: Computational Aspects
Anita Sarkar and Serge Pérez
Docking of Carbohydrates into Protein Binding Sites
Mark Agostino, Paul A. Ramsland, and Elizabeth Yuriev

Alternative Approaches for Yielding Detailed Structural Information
Mass Spectrometry for Glycomics Analysis of N- and O-Linked Glycoproteins
Daniel Kolarich and Nicolle H. Packer
Glycan-Based Arrays for Determining Specificity of Carbohydrate-Binding Proteins
Xuezheng Song, David F. Smith, and Richard D. Cummings

Carbohydrates in Medicine
Structural Glycobiology: Applications in Cancer Research
Inka Brockhausen and Yin Gao
Structural Glycobiology: Applications in Organ Transplantation
Dale Christiansen, Mark Agostino, Elizabeth Yuriev, Paul A. Ramsland, and Mauro S. Sandrin
Structural Glycobiology: Applications in Viral Infection
Rui Xu and Ian A. Wilson
Developing Drugs from Sugars Current State of Glycosaminoglycan-Derived Therapeutics
Neha S. Gandhi and Ricardo L. Mancera

Über Autor(innen)

Elizabeth Yuriev is with the Monash Institute for Pharmaceutical Sciences at Monash University, Australia. Paul A. Ramsland is with the Centre for Immunology at the Burnet Institute in Melbourne, Australia.