African Plant-Based Products as a Source of Potent Drugs to Overcome Cancers and their Chemoresistance

Part 1. Cancer Chemoresistance, Screening Methods, and the Updated cut-off Points for the Classification of Natural Cytotoxic Products
Erscheinungsjahr 2024
ISBN: 978-0-443-29338-2
Verlag: Elsevier Science & Technology

Buch, Englisch, Format (B × H): 152 mm x 229 mm, Gewicht: 1000 g

African Plant-Based Products as a Source of Potent Drugs to Overcome Cancers and their Chemoresistance: Part One: Cancer Chemoresistance, Screening, Methods, and the Updated cut-off Points for the Classification of Natural Cytotoxic Products, Volume 111 offers an overview of the potential of African medicinal plants as a source of anticancer agents to overcome with an emphasis on cancer drug resistance. Based on the collected data, the book also offers a rational classification basis for the cytotoxic activity of natural products. The general knowledge of state-of-the-art of cancer drug resistance globally and the screening methods for cytotoxic agents are described.

This book clearly identifies the best African medicinal plants that could be useful for the development of efficient herbal drugs, as well as the best phytochemicals that could be explored as potential pharmaceuticals to efficiently tackle cancers and their refractory phenotypes. The book appears a unique tool for Scientists for anticancer drug discovery from the exceptional flora of Africa.

Autoren/Hrsg.

Weitere Mitwirkende

Jacquot, Jean-Pierre

Kuete, Victor

Fachgebiete

• Naturwissenschaften Biowissenschaften Biowissenschaften

Inhaltsverzeichnis

1. Cancer, global burden, and drug resistance
Hermann Fongang
2. Screening methods of anticancer agents from natural source
Aimé G. Fankam and Victor Kuete
3. Established anticancer agents from plants
Armel J. Seukep and Victor Kuete
4. African medicinal plants and their derivative as the source of potent anti-leukemic products: rationale classification of naturally occurring anticancer agents
Victor Kuete
5. Potential of African medicinal plants against breast cancer and resistant phenotypes
Victor Kuete
6. Fighting colorectal cancer and its drug resistance with the resources of the flora of Africa
Victor Kuete
7. African medicinal plants and their constituents can fight glioblastoma and its drug resistance
Armelle T. Mbaveng and Victor Kuete
8. Fighting melanoma and resistant phenotypes African medicinal plants and their phytoconstituents
Brice E. N. Wamba, Armelle T. Mbaveng and Victor Kuete
9. Potential of African plants and their derived phytochemicals against hepatocellular carcinoma
Victor Kuete
10. Potential of African medicinal plants and their constituents to fight prostate cancer: An overview
Victor Kuete
11. Review of the potential of African medicinal plants and their derived products against pancreatic cancer
Victor Kuete
12. Activity of African medicinal plants against cervical cancer cells
Paul Nayim, Armelle T. Mbaveng and Victor Kuete
13. African medicinal plants and their phytochemicals can be used to combat lung cancer
Victor Kuete
14. Modes and mechanisms of action of potent cytotoxic plant-derived products from the flora of Africa
Victor Kuete

Über Autor(innen)

Jacquot, Jean-Pierre
Professor Jacquot has contributed to the elucidation of redox regulation in plants. Study of the thioredoxin and glutaredoxin systems and their molecular targets. His technical competence includes: plant biochemistry, genetic engineering, site directed mutagenesis, protein structure function relationship. He has 230 articles published in peer reviewed international journals. 180 accessible in Pubmed, 228 in ISI web. He has also been the Series Editor for Advances in Botanical Research (Elsevier) since 2011 and Editorial Board member of The Journal of Biological Chemistry from 2008-2013. He has been a senior member of Institut Universitaire de France since 2007 and received Gay-Lussac von Humboldt Prize Bundes Republik Deutschland Académie des sciences française, mention Biology 2009-2010. His past and present administrative duties include Member of Conseil National des Universités section 66 (2005-2007and 2011-today), Director of Structure Fédérative 4242 Ecosystèmes forestiers, Agroressources, Bioprocédés et Alimentation (EFABA) (since 2004), Director of Pôle de recherches A2F (Agronomie Agroalimentaire Forêt), Université de Lorraine (2006-2011, 2012-today) and Head of the group 'Stress response and redox regulation ' of UMR Interactions Arbres Microorganismes till 2012.

Kuete, Victor
Professor Victor Kuete is a scholar scientist at the University of Dschang, Cameroon. He has been a fellow of The Third World Academy of Science (TWAS; University of Pretoria, South Africa) in 2007, the French-speaking Countries' Organization (AUF; University of Marseille, France in 2008, The German Academic Exchange Service (DAAD; University of Mainz-Germany) in 2009, the University of Mainz-Germany (in 2010), Alexander von Humboldt fellow (University of Mainz-Germany) from 2012-2014, The Scientific and Technological Research Council of Turkey (TUBITAK; Eskisehir) in 2015. He has also been the grantee of The Alexander von Humboldt (2015-2018) and The International Foundation for Science (2008-2009; 2012-2013). His Research Program is focused on Pharmacognosy, and he mainly investigates African medicinal plants, phytochemicals isolated from medicinal plants such as terpenoids, phenolics, and alkaloids as well as synthetics, as potential antimicrobial, antiviral, and anti-cancer agents. He has a Google Scholar Hirsch index (h-index) of 84 (more than 18,000 citations; 2024) and is the author of >500 Scientific publications including several books and book chapters related to Medicinal Chemistry. Prof. Victor Kuete is the Editor-In-Chief of Investigational Medicinal Chemistry and Pharmacology, Associate Editor of the Journal of Ethnopharmacology, Section Editor of BMC Complementary and Alternative Medicine; Associate Editor of Evidenced-Based Complementary and Alternative Medicine, Editorial board member of Phytomedicine and several other journals. He has been recognized as the best Cameroon Scientist in 2022 and 2023 and is amongst the most renowned African Scientists by the AD Scientific Ranking for Scientists.