Buch, Englisch, 270 Seiten, Format (B × H): 183 mm x 260 mm, Gewicht: 712 g
Physiological Circuits and the Dynamics of Disease
Buch, Englisch, 270 Seiten, Format (B × H): 183 mm x 260 mm, Gewicht: 712 g
Reihe: Chapman & Hall/CRC Computational Biology Series
ISBN: 978-1-032-41228-3
Verlag: Chapman and Hall/CRC
Why do we get certain diseases, whereas other diseases do not exist?
In this book, Alon, one of the founders of systems biology, builds a foundation for systems medicine.
Starting from basic laws, the book derives why physiological circuits are built the way they are. The circuits have fragilities that explain specific diseases and offer new strategies to treat them.
By the end, the reader will be able to use simple and powerful mathematical models to describe physiological circuits. The book explores, in three parts, hormone circuits, immune circuits, and aging and age-related disease. It culminates in a periodic table of diseases.
Alon writes in a style accessible to a broad range of readers - undergraduates, graduates, or researchers from computational or biological backgrounds. The level of math is friendly and the math can even be bypassed altogether. For instructors and readers who want to go deeper, the book includes dozens of exercises that have been rigorously tested in the classroom
Zielgruppe
Postgraduate, Professional, and Undergraduate Advanced
Autoren/Hrsg.
Fachgebiete
- Mathematik | Informatik EDV | Informatik Programmierung | Softwareentwicklung Spiele-Programmierung, Rendering, Animation
- Mathematik | Informatik EDV | Informatik Daten / Datenbanken Datenbankdesign & Datenbanktheorie
- Naturwissenschaften Biowissenschaften Mikrobiologie
- Mathematik | Informatik EDV | Informatik Informatik Mensch-Maschine-Interaktion Informationsarchitektur
- Naturwissenschaften Biowissenschaften Angewandte Biologie Biophysik
- Medizin | Veterinärmedizin Medizin | Public Health | Pharmazie | Zahnmedizin Medizinische Fachgebiete Medizinische Mikrobiologie & Virologie
Weitere Infos & Material
Introduction. Part I Hormone Circuits. Chapter 1 The Insulin-Glucose Circuit. Chapter 2 Dynamical Compensation, Mutant Resistance, and Type-2 Diabetes. Chapter 2.5 Three Laws of Physiology. Chapter 3 The Stress Hormone Axis as a Two-Gland Oscillator. Chapter 3.5 The Thyroid and Its Discontents. Part II Immune Circuits. Chapter 4 Autoimmune Diseases as a Fragility of Mutant Surveillance. Chapter 5 Inflammation and Fibrosis as a Bistable System. Chapter 6 Basic Facts of Aging. Chapter 7 Aging and Saturated Repair. Chapter 8 Age-Related Diseases. Chapter 9 Periodic Table of Diseases. EPILOGUE: SIMPLICITY IN SYSTEMS MEDICINE. ACKNOWLEDGMENTS. INDEX.
