Animal Models of Disease Part C

Erscheinungsjahr 2025
ISBN: 978-0-443-22242-9
Verlag: Elsevier Science & Technology

Buch, Englisch, Format (B × H): 152 mm x 229 mm

Animal Models of Disease, Part C, Volume 192 in the Methods in Cell Biology series, highlights advances in the field, with this new volume presenting interesting chapters on a variety of timely topics, including Using C. Elegans as a model for Neurodegenerative disease: Methodology and Evaluation, Modelo Animal de Esclerosis Multiple: Encefalomielitis Autoimmune Experimental (EAE, New mouse model to study aneurysm development, Spinal Nerve Ligation: An Experimental Neuropathic Pain Model in Rats and Mice, Identifying therapeutic compounds for Autosomal Dominant Optic Atrophy (ADOA) through screening in the nematode C. elegans, Eµ-TCL1 adoptive transfer mouse model of chronic lymphocytic leukemia, and much more.

Other chapters cover Purification and characterization of kidney-infiltrating leukocytes in a mouse model of lupus nephritis, Differences in intratumor innate lymphoid cell composition between orthotopic and spontaneous pancreatic mouse models, Assessing motor development and function in mouse models of neurodevelopmental disorders, Analysis of Gut Microbiota profile targeted to multi hypervariable regions of 16S rRNA in hypertensive heart failure rat model, and more.

Autoren/Hrsg.

Weitere Mitwirkende

Martinez, Aitziber Buque

Bravo-San Pedro, Jose Manuel

Fachgebiete

• Naturwissenschaften Biowissenschaften Zellbiologie
• Naturwissenschaften Biowissenschaften Molekularbiologie
• Naturwissenschaften Biowissenschaften Entwicklungsbiologie

Inhaltsverzeichnis

Preface
Lorenzo Galluzzi, Fernando Aranda, Aitziber Buque and José Manuel Bravo-San Pedro
1. Characterizing tumour-infiltrating group 1 innate lymphoid cells in PyMT breast tumours
Nicolas Jacquelot, Sara Lamorte, Alisha Elford, Douglas Chung, Kiichi Murakami and Tracy McGaha
2. The current models unravel the molecular mechanisms underlying the intricate pathophysiology of Alzheimer’s disease using Zebrafish.
Ginpreet Kaur and Baban Thawkar
3. Colitis mouse model
Daniel Ajona, Yaiza Senent, Ana Remírez and Beatriz Tavira
4. Matching model with mechanism: appropriate animal models for studying various aspects of diabetes pathophysiology
Aileen King and Lydia Faith Daniels Gatward
5. Induction of sepsis in a rat model by the cecal ligation and puncture technique. Application for the study of experimental acute renal failure
Alberto Lazaro Fernandez Sr. and María Ángeles González-Nicolás
6. Human cancer cells xenografts to assess the efficacy of granulysin-based therapeutics
Alberto Anel Bernal
7. Antimicrobial regime for gut microbiota depletion in experimental mice models
Francisco Lozano, Laura Carrillo-Serradell, Alessandra Borgognone, Marc Noguera-Julian, Violeta Planells-Romeo, Lucía Aragón-Serrano, Mariona Parera, Sergi Casadó-Llombart, María Velasco-de Andrés and Roger Paredes
8. Evaluating polyglutamine protein aggregation and toxicity in transgenic Caenorhabditis elegans models of Huntington's disease
Leticia Priscilla Arantes and Felix Alexandre Antunes Soares
9. A model of intraperitoneal ovarian cancer to study tumor responses to radioimmunotherapy
Julie Constanzo, Jean-Pierre POUGET, Clara Diaz Garcia-Prada and Salima Atis
10. Metallic nanoparticles biodistribution for the study of lymphoma in animal models
Laura Mondragón Martínez, Barbara Chalhoub and Víctor F. Puntes
11. Stereotactic injection of murine brain tumor cells for neuro-oncology studies
Mara De Martino, Claire I. Vanpouille-Box, Camille Daviaud and María Cecilia Lira
12. Evaluating amyloid-beta aggregation and toxicity in transgenic Caenorhabditis elegans models of Alzheimer's disease
Leticia Priscilla Arantes, Felix Alexandre Antunes Soares and Larissa Marafiga Cordeiro

Über Autor(innen)

Bravo-San Pedro, Jose Manuel
Jose Manuel Bravo-San Pedro is currently a researcher at the Department of Physiology of the Complutense University of Madrid thanks to a Ramon y Cajal contract grant. He got his Ph.D. in biochemistry, cellular biology and genetics from the University of Extremadura (Caceres, Spain) in 2011, and he did a post-doctoral stage in the laboratory of Prof. Guido Kroemer. His main research interests have always been linked to autophagy, addressing this cellular process associated with neurodegenerative diseases or cancer and recently obesity and specifically related to problems in the correct functioning of the cilium. He is co-inventor of two patents and co-author of 110 publications indexed in PubMed in prestigious international journals, with h-index 45 and 23768 cites (Dec 2022).

Martinez, Aitziber Buque
Aitziber Buqué is currently a Post-Doctoral Associate with the Galluzzi Lab, in the Department of Radiation Oncology at Weill Cornell Medical College (New York), where she investigates innate and acquired mechanisms of resistance to immunotherapy in HR+ breast cancer and radiotherapy as a means to overcome them. Prior to joining the Galluzzi Lab (2018), Aitziber was a Post-Doctoral Associate with the Kroemer Lab in the Cordeliers Research Center (Paris, France; 2014-2018), after receiving her M.Sc. in Bioinformatics and Computational Biology (2006) from the Complutense University (Madrid, Spain) and her Ph.D. in Biomedicine (2013) from the BioCruces Research Institute (Barakaldo, Spain). Aitziber has a long-standing interest in the immunological mechanisms controlling cancer progression and response to treatment.