Viscoelasticity and Collective Cell Migration

An Interdisciplinary Perspective Across Levels of Organization
Erscheinungsjahr 2021
ISBN: 978-0-12-820310-1
Verlag: William Andrew Publishing

Buch, Englisch, 314 Seiten, Format (B × H): 191 mm x 235 mm, Gewicht: 500 g

Viscoelasticity and Collective Cell Migration: An Interdisciplinary Perspective Across Levels of Organization focuses on the main viscoelastic parameters formulated based on multiscale constitutive modeling and how to measure these rheological parameters based on existent micro-devices such as micro-rheology and micro-elastography. The book sheds light on inter-relationships across viscoelasticity scales, an essential step for understanding various biomedical processes such as morphogenesis, wound healing and cancers invasion. Cumulative effects of structural changes at subcellular and cellular levels influence viscoelasticity at a supracellular level are also covered, providing valuable insights for biologists, physicists, engineers, students and researchers in the field of developmental biology.

As this is a complex multidisciplinary field, perspectives are included from experts in biology, biochemistry, biomedicine, biophysics and biorheology. Readers will gain a deeper understanding of the complex dynamics that represent challenges and the necessity for further development in the field.

Autoren/Hrsg.

Barriga, Elias

Fachgebiete

• Naturwissenschaften Biowissenschaften Zellbiologie
• Naturwissenschaften Biowissenschaften Entwicklungsbiologie
• Naturwissenschaften Biowissenschaften Angewandte Biologie Biophysik
• Naturwissenschaften Physik Mechanik Kontinuumsmechanik, Strömungslehre
• Technische Wissenschaften Maschinenbau | Werkstoffkunde Technische Mechanik | Werkstoffkunde Kontinuumsmechanik
• Naturwissenschaften Physik Angewandte Physik Biophysik
• Medizin | Veterinärmedizin Medizin | Public Health | Pharmazie | Zahnmedizin Vorklinische Medizin: Grundlagenfächer Biomechanik

Inhaltsverzeichnis

1. Viscoelastic Impedance of Cells and Tissues -Basic Concepts and Physiological Functions 2. Recent advances in imaging of cell elasticity 3. Biophysical origins of viscoelasticity during collective cell migration 4. Intrinsic and extrinsic viscoelasticity modulates cell migration in vivo 5. Effects of time delays and viscoelastic parameters in oscillatory response cell monolayers 6. Mechanical changes driving 3D cell motility in development and cancer 7. Comparing interfacial, viscous and elastic contributions during 3D cell aggregate rearrangements 8. Viscoelasticity of multicellular systems caused by collective cell migration: multi scale modelling considerations 8. Flow dynamics of 3D multicellular systems under confinement 9. Multicellular systems response under stress: From subcellular to supracellular levels 10. Cytoskeletal and cell adhesion contributions to tissue stresses 11. Confinement-induced transition between wave-like collective cell migration modes

Über Autor(innen)

Barriga, Elias
Dr. Elias Barriga is a former University College London postdoc and current group leader at Instituto Gulbenkian de Ciencia (IGC), Portugal Lisbon. His research focuses in understanding how mechano-molecular interactions synchronise morphogenesis in development and regeneration.