Recent Advances in Glucocorticoid Receptor Action

2002
ISBN: 978-3-540-43229-6
Verlag: Springer Berlin Heidelberg

Buch, Englisch, Band 40, 380 Seiten, HC runder Rücken kaschiert, Format (B × H): 157 mm x 235 mm, Gewicht: 813 g

Reihe: Ernst Schering Foundation Symposium Proceedings

Since 1948, hydrocortisone (cortisol), the principal glucocorticoid (GC) of the human adrenal cortex has been successfully used at phar­ macological concentrations for the suppression of clinical manifesta­ tions of rheumatoid arthritis. Numerous compounds with GC activity have also been developed and used. Fifty years after their initial clinical use, GCs are still the most im­ portant and frequently prescribed class of anti-inflammatory drugs for various inflammatory disorders. They are administered either orally, parenterally (intravenous, intramuscular, intrathecal), or topically (cu­ taneous, intranasal, pulmonic, rectal). Despite the many beneficial ef­ fects of GCs, they also have their limitations and disadvantages that occur with varying prevalence on different organs and after different durations of therapy. These side-effects can range in severity from cos­ metic (e.g. telangiectasias, hypertrichosis) to seriously disabling (e.g. induction of glaucoma, diabetes, osteoporosis) or even life-threatening disorders (e.g. gastric haemorrhage). These adverse effects of GCs se­ riously handicap their successful use as anti-inflammatory agents. There is therefore a strong need for the development of substances with the anti-inflammatory potency of classical GCs but with reduced side-effects.

Zielgruppe

Research

Autoren/Hrsg.

Cato, A.

Asadullah, K.

Schaecke, H.

Fachgebiete

• Naturwissenschaften Biowissenschaften Biochemie (nichtmedizinisch)
• Medizin | Veterinärmedizin Medizin | Public Health | Pharmazie | Zahnmedizin Medizinische Fachgebiete Pharmakologie, Toxikologie
• Medizin | Veterinärmedizin Medizin | Public Health | Pharmazie | Zahnmedizin Klinische und Innere Medizin Endokrinologie
• Medizin | Veterinärmedizin Medizin | Public Health | Pharmazie | Zahnmedizin Klinische und Innere Medizin Immunologie
• Naturwissenschaften Biowissenschaften Tierkunde / Zoologie Tierphysiologie
• Medizin | Veterinärmedizin Medizin | Public Health | Pharmazie | Zahnmedizin Vorklinische Medizin: Grundlagenfächer Molekulare Medizin, Zellbiologie

Inhaltsverzeichnis

1 Glucocorticoids and Asthma.- 2 Immune Monitoring of Glucocorticoid Therapy.- 3 Topical Glucocorticoid Therapy in Dermatology.- 4 Bone Effects of Glucocorticoid Therapy.- 5 Corticosteroids in Ophthalmology.- 6 Special Problems in Glucocorticoid Treatment in Children.- 7 Functional Implications of Glucocorticoid Receptor Trafficking.- 8 The Dynamics of Intranuclear Movement and Chromatin Remodeling by the Glucocorticoid Receptor.- 9 Glucocorticoid Receptor Antagonism of AP-1 Activity by Inhibition of MAPK Family.- 10 Mast Cells as Targets for Glucocorticoids in the Treatment of Allergic Disorders.- 11 Cytosolic Glucocorticoid Receptor-Interacting Proteins.- 12 The Glucocorticoid Receptor ?-Isoform: A Perspective on Its Relevance in Human Health and Disease.- 13 Cooperation of Nuclear Transcription Factors Regulated by Steroid and Peptide Hormones.- 14 Induction and Repression of NF-?B-Driven Inflammatory Genes.- 15 DNA-Dependent Cofactor Selectivity of the Glucocorticoid Receptor.- 16 The Anti-inflammatory Action of Glucocorticoid Hormones.- 17 Analysis of Glucocorticoid Receptor Function in the Mouse by Gene Targeting.- 18 Glucocorticoid-Inducible Genes That Regulate T-Cell Function.- 19 Structural Analysis of the GR Ligand-Binding Domain.- 20 SEGRAs: A Novel Class of Anti-inflammatory Compounds.- Previous Volumes Published in This Series.