Pharmacogenomics

Challenges and Opportunities in Therapeutic Implementation
Erscheinungsjahr 2013
ISBN: 978-0-12-391918-2
Verlag: William Andrew Publishing

Buch, Englisch, Format (B × H): 191 mm x 235 mm, Gewicht: 1200 g

Pharmacogenomics: Challenges and Opportunities in Therapeutic Implementation includes discussions and viewpoints from the academic, regulatory, pharmaceutical, clinical, socio-ethical and economic perspectives. Each chapter presents an overview of the potential or opportunity within the areas discussed and also outlines foreseeable challenges and limitations in moving pharmacogenomics into drug development and direct therapeutic applications. This edited book contains review questions for a more in-depth analysis of the implications of pharmacogenomics and discussion points to generate ideas on best to move the field forward. Clinical pearls and case studies are used to illustrate real-life experiences and both successful and unsuccessful applications. Tables, figures, and annotations are included throughout the book to facilitate understanding and further reference.

Zielgruppe

<p>This book is intended for scientists and clinicians interested in pharmacogenomics implementation in academic, research, medical and pharmaceutical industry settings. Relevant fields include pharmacology, pharmaceutical sciences, genetics, molecular biology and medicine.This book may also be used as a recommended textbook for pharmacy students and graduate-level students in health and pharmaceutical science programs. </p>

Autoren/Hrsg.

Cavallari, Larisa H.

Fachgebiete

• Medizin | Veterinärmedizin Medizin | Public Health | Pharmazie | Zahnmedizin Medizinische Fachgebiete Pharmakologie, Toxikologie
• Medizin | Veterinärmedizin Medizin | Public Health | Pharmazie | Zahnmedizin Pharmazie
• Naturwissenschaften Chemie Chemie Allgemein Pharmazeutische Chemie, Medizinische Chemie
• Technische Wissenschaften Verfahrenstechnik | Chemieingenieurwesen | Biotechnologie Pharmazeutische Technologie

Inhaltsverzeichnis

SECTION 1

1 Principles of Pharmacogenomics: Pharmacokinetic, Pharmacodynamic, and Clinical Implications 2 Translating Pharmacogenomic Research to Therapeutic Potentials 3 Governmental and Academic Efforts to Advance the Field of Pharmacogenomics (PGRN CPIC, PharmGKB)

Section 2

4a Pharmacogenomics in Cancer Therapeutics 4b A Look to the Future:  Cancer epigenetics 5a Pharmacogenomics in Cardiovascular Diseases 5b A Look to the Future: Cardiovascular Pharmaco-epigenetics 6a Pharmacogenomics in Psychiatry Disorders 6b A Look to the Future: Epigenetics in psychiatric disorders and treatment 7 Role of Pharmacogenomics in Diabetes and Other Therapeutic Areas 

SECTION 3

8a Molecular Approaches, Models, and Techniques in Pharmacogenomic Research and Development 8b Molecular Approaches, Models, and Techniques in Pharmacogenomic Research and Development 9a Incorporating Pharmacogenomics in Drug Development Part 1:  Rational  study designs for pharmacogenetic research and therapy - A perspective  from academia 9b Incorporating Pharmacogenomics in Drug Development Part 2:  A perspective from industry 10 Ethnobridging and Pharmacogenomics

SECTION 4

11 Beyond ELSIs - Where to from here? From 'Regulator' to Anticipating and Shaping the Innovation Trajectory in Personalized Medicine 12 The Economics of Pharmacogenomics

SECTION 5

13 Integrating Genomics into Pharmacy Education and Practice: Pharmacogenomics is not enough