Mitochondrial Biology

New Perspectives
1. Auflage 2007
ISBN: 978-0-470-06657-7
Verlag: Wiley

Buch, Englisch, 254 Seiten, Format (B × H): 159 mm x 237 mm, Gewicht: 535 g

Reihe: Novartis Foundation Symposium

The field of mitochondrial research has experienced a renaissance in recent years encompassing a complete re-evaluation of mitochondrial biochemistry and biology. It is now clear that mitochondria are not only involved in the business of ATP synthesis, but are also intimately involved in cell signalling and, particularly, in cell death.

Containing contributions from many of the leading laboratories in mitochondrial biology worldwide, this book provides a timely summary of the current state-of-the-art research. It opens with coverage of the regulation of mitochondrial replication and biogenesis and a review of the mechanisms and functional consequences of mitochondrial fission and fusion.

Further chapters address the topic of mitochondria and oxidative stress and their roles in cell signalling and cell death: key steps in the progression of programmed cell death are initiated by mitochondrial signals and key steps in the progression of necrotic cell death start with mitochondrial dysfunction. The nature of the proteins engaged in these processes, many only recently discovered, is covered in detail.

As we learn more about these novel proteins and mechanisms - including the permeability transition pore and ion channels - we begin to see how they may play a role in cell physiology and pathology. Mitochondria have been strongly implicated in neurodegenerative diseases such as Parkinson's, Huntington's and amyotrophic lateral sclerosis. They are also affected in cancer, ageing and cardiovascular disease. The final section of the book reviews mitochondrial mutations and their consequences in ageing and other phenotypic manifestations. The authors discuss how mitochondrial proteins might constitute important therapeutic targets and describe initial attempts to develop compounds that can regulate their function.

Mitochondrial Biology: New Perspectives includes extensive and lively discussions amongst the authors and will be of interest to cell and molecular biologists, biochemists, neuroscientists and neurologists working in this fascinating field.

Autoren/Hrsg.

Chadwick, Derek J

Goode, Jamie A

Fachgebiete

• Medizin | Veterinärmedizin Medizin | Public Health | Pharmazie | Zahnmedizin Klinische und Innere Medizin Innere Medizin
• Medizin | Veterinärmedizin Medizin | Public Health | Pharmazie | Zahnmedizin Vorklinische Medizin: Grundlagenfächer Physiologie
• Naturwissenschaften Biowissenschaften Zellbiologie

Inhaltsverzeichnis

David G. Nicholls Chair's introduction

Albert Neutzner, Richard J. Youle and Mariusz Karbowski

Outer mitochondrial membrane protein degradation by the proteasome

Discussion

Sarah E. Haigh, Gilad Twig, Anthony A. J. Molina, Jakob D. Wikstrom,

Motti Deutsch and Orian S. Shirihai PA-GFP: a window into

the subcellular adventures of the individual mitochondrion

Discussion

Luca Scorrano Multiple functions of mitochondria-shaping proteins

Discussion

Bruce M. Spiegelman Transcriptional control of mitochondrial energy

metabolism through the PGC1 coactivators

Discussion

Charles Affourtit, Paul G. Crichton, Nadeene Parker and Martin D. Brand

Novel uncoupling proteins

Discussion

Cecilia Giulivi Mitochondria as generators and targets of

nitric oxide

Discussion

György Hajnóczky, Masao Saotome, György Csordás, David Weaver and

Muqing Yi Calcium signalling and mitochondrial motility

Discussion

Anna Romagnoli, Paola Aguiari, Diego De Stefani, Sara Leo,

Saverio Marchi, Alessandro Rimessi, Erika Zecchini, Paolo Pinton

and Rosario Rizzuto Endoplasmic reticulum/mitochondria calcium

cross-talk

Discussion

Brian O'Rourke, Sonia Cortassa, Fadi Akar and Miguel Aon

Mitochondrial ion channels in cardiac function and dysfunction

Discussion

Paolo Bernardi and Michael Forte The mitochondrial permeability

transition pore

Discussion

Dominic James, Philippe A. Parone, Olivier Terradillos,

Safa Lucken-Ardjomande, Sylvie Montessuit and

Jean-Claude Martinou Mechanisms of mitochondrial outer membrane

permeabilization

Discussion

M. Flint Beal Mitochondria and neurodegeneration

Discussion

Mügen Terzioglu and Nils-Göran Larsson Mitochondrial dysfunction in

mammalian ageing

Discussion

Eric A. Schon and Salvatore DiMauro Mitochondrial mutations: genotype

to phenotype

Discussion

Contributor Index

Subject index

Über Autor(innen)

The Novartis Foundation is an international scientific and educational charity which promotes the study and general knowledge of science and in particular encourages international co-operation in scientific research.

Chairman: David G Nicholls, Buck Institute for Age Research, Novato, USA.