Dancing Protein Clouds: Intrinsically Disordered Proteins in the Norm and Pathology, Part C

Erscheinungsjahr 2021
ISBN: 978-0-323-85299-9
Verlag: William Andrew Publishing

Buch, Englisch, 434 Seiten, Format (B × H): 152 mm x 229 mm, Gewicht: 450 g

Dancing Protein Clouds: Intrinsically Disordered Proteins in the Norm and Pathology, Part C, Volume 183 represents a set of selected studies on a variety of research topics related to intrinsically disordered proteins. Topics in this volume include discussions on the evolution of disorder, consideration of the peculiarities of phase separation of the prion protein, a general discussion of the relationships between intrinsic disorder and protein functions, coverage of the structural and functional characterization of several important intrinsically disordered proteins, such as transcription factors, outer membrane porins, trans-membrane and membrane associated proteins with ID regions, discussion of molecular simulations of IDPs, and much more.

Zielgruppe

<p>Scientists working in the fields of biochemistry, biophysics, molecular medicine, biotechnology, pharmacology and drug discovery, molecular and cellular biology, as well as students of Medical Schools, Departments of Biochemistry, Biophysics, Molecular Biology, Biotechnology, Cell Biology, etc. This book is of interest to everybody, who is fascinated by the protein intrinsic disorder phenomenon, including graduate students, postdoctoral students, and experienced researchers studying intrinsically disordered proteins (IDPs), their structures, and functions.</p>

Autoren/Hrsg.

Weitere Mitwirkende

Uversky, Vladimir N

Fachgebiete

• Naturwissenschaften Biowissenschaften Biochemie (nichtmedizinisch)
• Naturwissenschaften Biowissenschaften Molekularbiologie

Inhaltsverzeichnis

1. Intrinsic disorder and phase transitions: Pieces in the puzzling role of the prion protein in health and disease

Mariana J. do Amaral and Yraima Cordeiro

2. Functions of intrinsically disordered proteins through evolutionary lenses

Mátyás Pajkos and Zsuzsanna Dosztányi

3. Non-specific porins of Gram-negative bacteria as proteins containing intrinsically disordered regions with amyloidogenic potential

Olga D. Novikova, Vladimir N. Uversky and Elena A. Zelepuga

4. Intrinsic disorder in integral membrane proteins

Brian J. Aneskievich, Rambon Shamilov and Olga Vinogradova

5. Molecular simulations of IDPs: From ensemble generation to IDP interactions leading to disorder-to-order transitions

Hebah Fatafta, Suman Samantray, Abdallah Sayyed-Ahmad, Orkid Coskuner-Weber and Birgit Strodel

6. Target-binding behavior of IDPs via pre-structured motifs

Do-Hyoung Kim and Kyou-Hoon Han

7. The role of dancing duplexes in biology and disease

Heather M. Forsythe and Elisar Barbar

8. Intrinsic disorder in protein kinase A anchoring proteins signaling complexes

Mateusz Dyla and Magnus Kjaergaard

9. Protein intrinsic disorder on a dynamic nucleosomal landscape

Sveinn Bjarnason, Sarah F. Ruidiaz, Jordan McIvor, Davide Mercadante and Pétur O. Heidarsson

10. Flexible spandrels of the global plant virome: Proteomic-wide evolutionary patterns of structural intrinsic protein disorder elucidate modulation at the functional virus-host interplay

Rachid Tahzima, Annelies Haegeman, Sébastien Massart and Eugénie Hébrard

Über Autor(innen)

Uversky, Vladimir N
Prof. Vladimir N. Uversky, PhD, DSc, FRSB, FRSC, F.A.I.M.B.E., Professor at the Department of Molecular Medicine, Morsani College of Medicine, University of South Florida (USF), is a pioneer in the field of protein intrinsic disorder. He has made a number of groundbreaking contributions in the field of protein folding, misfolding, and intrinsic disorder. He obtained his academic degrees from Moscow Institute of Physics and Technology (Ph.D., in 1991) and from the Institute of Experimental and Theoretical Biophysics, Russian Academy of Sciences (D.Sc., in 1998). He spent his early career working mostly on protein folding at the Institute of Protein Research and the Institute for Biological Instrumentation (Russia). In 1998, moved to the University of California Santa Cruz. In 2004, joined the Indiana University?Purdue University Indianapolis as a Senior Research Professor. Since 2010, Professor Uversky is with USF, where he works on various aspects of protein intrinsic disorder phenomenon and on analysis of protein folding and misfolding processes. Prof. Uversky has authored over 1250 scientific publications and edited several books and book series on protein structure, function, folding, misfolding, and intrinsic disorder. He is also serving as an editor in a number of scientific journals. He was a co-founder of the Intrinsically Disordered Proteins Subgroup at the Biophysical Society and the Intrinsically Disordered Proteins Gordon Research Conference. Prof. Uversky collaborated with more than 12,500 colleagues from more than 2,750 research organizations in 89 countries/territories.