Advances in Antiviral Drug Design

Erscheinungsjahr 2007
ISBN: 978-0-444-52173-6
Verlag: Elsevier Science & Technology

Buch, Englisch, 264 Seiten, Format (B × H): 152 mm x 229 mm, Gewicht: 550 g

Regularly reviewing the "state-of-the-art" developments in the antiviral drug research field, this latest volume spans the conceptual design and chemical synthesis of new antiviral compounds. It discusses their structure-activity relationship, mechanism and targets of action, pharmacological behavior, antiviral activity spectrum, and therapeutic potential for clinical use.

Zielgruppe

Researchers, academics and postgraduates working in medical virology and infectious diseases, chemotherapy and drug discovery

Autoren/Hrsg.

De Clercq, E.

Fachgebiete

• Technische Wissenschaften Verfahrenstechnik | Chemieingenieurwesen | Biotechnologie Kosmetische Technologie
• Naturwissenschaften Biowissenschaften Mikrobiologie
• Medizin | Veterinärmedizin Medizin | Public Health | Pharmazie | Zahnmedizin Medizinische Fachgebiete Medizinische Mikrobiologie & Virologie
• Naturwissenschaften Biowissenschaften Biochemische Immunologie
• Medizin | Veterinärmedizin Medizin | Public Health | Pharmazie | Zahnmedizin Medizinische Fachgebiete Pharmakologie, Toxikologie

Inhaltsverzeichnis

Status presens of antiviral drugs and strategies, Part I: DNA viruses and retroviruses
Status presens of antiviral drugs and strategies, Part II: RNA viruses (except retroviruses)
Methylenecyclopropane analogues of nucleosides as anti-herpes agents
Synthesis and antiviral evaluation of broad spectrum orally active analogs of cidofovir and other acyclic nucleoside phosphonates
CCR5 antagonists for the treatment of HIV infection and AIDS
The medicinal chemistry of the DATA and DAPY series of HIV-1 non-nucleoside reverse transcriptase inhibitors (NNRTIs)