Protein Interactions as Targets in Drug Discovery

Erscheinungsjahr 2020
ISBN: 978-0-12-816846-2
Verlag: William Andrew Publishing

Buch, Englisch, 316 Seiten, Format (B × H): 152 mm x 229 mm, Gewicht: 630 g

Protein Interactions as Targets in Drug Discovery, Volume 121, is dedicated to the design of therapeutics, both experimental and computational, that target protein interactions. Chapters in this new release include Trends in structure based drug design with protein targets, From fragment- to peptide-protein interaction: addressing the structural basis of binding using Supervised Molecular Dynamics (SuMD), Protein-protein and protein-ligand interactions: identification of potential inhibitors through computational analysis, Aromatic-aromatic interactions in protein-drug and protein-protein interactions, Role of protein-protein interaction in allosteric drug design within the human methyltransferome, and much more.

Zielgruppe

<p>This volume would be of great interest to a very wide audience - protein chemists, molecular cell biologists, immunologists, structural biologists, computational biochemists, medical doctors, pharmacologists and other researchers working in the field of protein interactions. Articles published here would also be of a considerable benefit to medical, biology and pharmacology students specializing in this field. </p>

Autoren/Hrsg.

Donev, Rossen

Fachgebiete

• Naturwissenschaften Biowissenschaften Zellbiologie
• Naturwissenschaften Biowissenschaften Biowissenschaften DNA und Transgene Organismen
• Naturwissenschaften Biowissenschaften Molekularbiologie
• Naturwissenschaften Biowissenschaften Biowissenschaften Genetik und Genomik (nichtmedizinisch)
• Naturwissenschaften Biowissenschaften Proteinforschung
• Naturwissenschaften Biowissenschaften Biochemie (nichtmedizinisch)

Inhaltsverzeichnis

1. Latest trends in structure based drug design with protein targets Angshuman Bagchi 2. From fragment- to peptide-protein interaction: addressing the structural basis of binding using Supervised Molecular Dynamics (SuMD) Stefano Moro 3. Protein-protein and protein-ligand interactions: identification of potential inhibitors through computational analysis M. Michael Gromiha 4. Aromatic-aromatic interactions in protein-drug and protein-protein interactions Adrian Gustavo Turjanski 5. Role of protein-protein interaction in allosteric drug design within the human methyltransferome Guang Hu 6. Protein-Protein Interactions as the Basis for Cyclin-Dependent Kinase Inhibition Mark Klein 7. Targeting FOXP3 complex ensemble in drug discovery Bin Li 8. Targeting arrestin interactions with its partners for therapeutic purposes Vsevolod V. Gurevich 9. Protein interactomics in kidney stone research Visith Thongboonkerd 10. Human oral microbiome protein-protein interaction: a cross-talk with health systemic implications Marlene M.T. Barros 11. Protein-protein complexes as targets for drug discovery against infectious diseases Yusuf Akhter 12. Therapeutic intervention of protein-protein interactions in innate immunity Kevin J. Lumb 13. Physicochemical determinants of antibody-protein interactions Sibel Kalyoncu Uzunlar

Über Autor(innen)

Donev, Rossen
Rossen Donev received his PhD degree in 1999 from the Institute of Molecular Biology, Bulgarian Academy of Sciences. He did postdoctoral training at Imperial Cancer Research Fund, UK (renamed after the merger with Cancer Research Campaign to Cancer Research UK, London Research Institute) and Cardiff University. In 2007 he was awarded a New Investigator Grant Award from the Medical Research Council (UK) to establish himself as an independent Principle Investigator. In 2010 Dr. Donev was appointed Senior Lecturer at Swansea University. In 2016 Dr. Donev joined MicroPharm Ltd (UK) where currently he is Head of Research. He has published more than 60 research papers, chaired scientific meetings and given invited plenary talks. Rossen Donev has consulted on projects related to development of treatments for neurodevelopmental disorders and cancer therapies. He serves as Editor-in-Chief of the Advances in Protein Chemistry and Structural Biology and on editorial board of several other journals. His research interests include signaling pathways involved in neuropsychiatric disorders and tumor escape from the immune system, and development of therapeutic strategies for their treatment. More recently he has focused on development of immunotherapeutics for non-systemic applications.