Festoff Serine Proteases and Their Serpin Inhibitors in the Nervous System

Regulation in Development and in Degenerative and Malignant Disease
Erscheinungsjahr 2012
ISBN: 978-1-4684-8357-4
Verlag: Springer US
Format: PDF
Kopierschutz: 1 - PDF Watermark

E-Book, Englisch, Band 191, 384 Seiten, eBook

Reihe: NATO Science Series A:

Zielgruppe

Research

Autoren/Hrsg.

Festoff, Barry W.

Inhaltsverzeichnis

Section I: Biochemistry and Cell Biology of Serine Proteases and Serpins.- 1: Thrombin Structural Regions in Determining Bioregutatory Functions.- 2: Regulation and Control of the Fibrinolytic System.- 3: A Key Molecule Dictating and Regulating Surface Plasmin Formation: The Receptor for Urokinase Plasminogen Activator.- 4: Regulation of Tissue Plasminogen Activator Secretion from Human Endothelial Cells.- 5: Thrombin Disintegrates Cell Surface Urokinase Focal Adhesion Plaques and Decreases Cell Extension: Implications for Axonal Growth.- 6: Structure and Function of Tissue-Type Plasminogen Activator.- 7: The Heparin Binding Site and Activation of Protease Nexin I.- 8: Polypeptide Chain Structure of Inter-?-Trypsin Inhibitor and Pre-?-Trypsin Inhibttor: Evidence for Chain Assembly by Glycan and Comparison with Other “Kunin”-Containing Proteins.- 9: Regulation of Protease Nexin I Activity and Target Protease Specificity by the Extracellular Matrix.- Section II: Molecular Biology of Serine Proteases and Serpins.- 10: Induction of the Urokinase-Type Plasminogen Activator Gene by Cytoskeeton-Disrupting Agents.- 11: Use of Protein Chemistry and Molecular Biology to Determine Interaction Areas Between Proteases and Their Inhibitors: The Thrombin-Hirudin Interaction as an Example.- 12: Signal Transduction Chains Involved in the Control of the Fibrinolytic Enzyme Cascade.- 13: Rodent Serpins: Accelerated Evolution and Novel Specificities.- 14: Structure of the Human Protease Nexin Gene and Expression of Recombinant forms of PNI.- 15: Evolutionary Adaptations of Serpins and Their Use in Designing New Proteinase Inhibitors.- Section III: Serine Proteases in the Nervous System.- 16: Plasminogen Activator in the Developing Nervous System.- 17: Multiple Roles for PlasminogenActivator System in Nervous System Development.- 18: Interaction of Plasminogen Activators with the Neuronal Surface.- 19: Glial Plasminogen Activators in Developing and Regenerating Neural Tissue.- 20: Plasminogen Activators in Development, Injury and Pathology of the Neuromuscular System.- 21: Relationship Between Plasminogen Activators and Regeneration Capacities of Rat Skeletal Muscle.- Section IV: Balance of Proteases and Serpins in the Nervous System.- 22: A Cascade Approach to Synapse Formation Based on Thrombogenic and Fibrinolytic Models.- 23: Localized Extracellular Proteolysis May Convey Inductive Signals Between Nerve and Muscle Cells During Synaptogenesis.- 24: Steps in Establishing a Biological Relevance for Gliaderived Nexin.- Section V: Serpins in Degenerative and Malignant Neurologic Diseases.- 25: Protease Inhibitors in Neurologic Diseases.- 26: Presence and Significance of ?1-Antitrypsin in Human Brain Tumors.- 27: Serpins and Brain Tumors: Roles in Pathogenesis.- 28: A Serine Protease Inhibitor Domain Encoded Within the Alzheimer Disease Associated Amyloid ?-Protein Precursor Gene.- 29: The Serpin, al-Antichymotrypsin, in Brain Aging and Diseases of The Nervous System.- 30: Protease Nexin I Immunostaining in Alzheimer’s Disease.- Section VI: The Maratea Conference.- Photo Layout.- Participants.