Folic Acid and Folates

Erscheinungsjahr 2008
ISBN: 978-0-12-374232-2
Verlag: William Andrew Publishing

Buch, Englisch, 480 Seiten, Format (B × H): 152 mm x 229 mm, Gewicht: 750 g

First published in 1943, Vitamins and Hormones is the longest-running serial published by Academic Press. In the early days of the serial, the subjects of vitamins and hormones were quite distinct. The Editorial Board now reflects expertise in the field of hormone action, vitamin action, X-ray crystal structure, physiology, and enzyme mechanisms.

Zielgruppe

Researchers, faculty, and graduate students interested in cutting-edge review concerning the molecular and cellular biology of vitamins, hormones, and related factors and co-factors. Libraries and laboratories at institutes with strong programs in cell biology, biochemistry, molecular biology, gene regulation, hormone control, and signal transduction are likely to be interested.

Autoren/Hrsg.

Weitere Mitwirkende

Litwack, Gerald

Fachgebiete

• Medizin | Veterinärmedizin Medizin | Public Health | Pharmazie | Zahnmedizin Vorklinische Medizin: Grundlagenfächer Physiologie

Inhaltsverzeichnis

1. Folate-Mediated One-Carbon MetabolismJennifer T. Fox and Patrick J. Stover2. Mathematical Models of Folate-Mediated One-Carbon Metabolism H. Frederik Nijhout, Michael C. Reed and C.M. Ulrich3. Folate Deprivation, the Methionine Cycle and Alzheimer¡¦s DiseaseFlaubert Tchantchou and Thomas B. Shea4. Benefits and Risks of Folic Acid Supplementation Young-In Kim5. Molecular Mechanisms of Adaptation to Folate DeficiencyIlan Ifergan and Yehuda G. Assaraf6. Structure and Function of the Reduced Folate Carrier: A Paradigm of a Major Facilitator Superfamily Mammalian Nutrient TransporterLarry H. Matherly and Zhanjun Hou 7. Renal Conservation of Folates: Role of Folate Transport ProteinsVijaya L. Damaraju, Carol E. Cass and Michael B. Sawyer8. Exploitation of the Folate Receptor in the Management of Cancer and Inflammatory DiseaseChristopher P. Leamon and Ann L. Jackman9. Folate Receptor Expression in Pituitary Adenomas: Cellular and Molecular Analysis Chheng-Orn Evans, Congjun Yao, David Leborde and Nelson M. Oyesiku10. Regulation of Human Dihydrofolate Reductase Activity and ExpressionEmine Ercikan Abali, Nancy E. Skacel, Hilal Celikkaya, Yi-Ching Hsieh11. Catalysis of Methyl Group Transfers Involving Tetrahydrofolate and B12Stephen W. Ragsdale12. Methyltetrahydrofolate in Folate-Binding Protein Glycine N-MethyltransferaseZigmund Luka13. Mechanism-Based Inhibitors of Folylpoly-f×-glutamate Synthetase and f×-Glutamyl Hydrolase: Control of Folylpoly-f×-glutamate Homeostasis as a Drug TargetJames K. Coward and John J. McGuire14. Methylenetetrahydrofolate Reductase, Common Polymorphisms and Relation to DiseasePhilip Thomas and Michael Fenech15. Mitochondrial Methylenetetrahydrofolate Dehydrogenase, Methenyltetrahydrofolate Cyclohydrolase and Formyltetrahydrofolate SynthetasesKaren E. Christensen and Robert E. MacKenzie16. The Structure and Mechanism of 6-Hydroxymethyl-7,8-dihydropterin PyrophosphokinaseJeremy P. Derrick

Über Autor(innen)

Litwack, Gerald
Dr. Litwack has authored 3 textbooks on biochemistry and hormones (one with John Wiley & Sons and 2 with Academic Press/Elsevier) and he has edited more than 70 volumes in the Vitamins & Hormones series (Academic Press/Elsevier); he has edited 14 volumes entitled Biochemical Actions of Hormones (Academica Press); He has edited (with David Kritchevsky) Actions of Hormones on Molecular Processes (Academic Press)

Trained in biochemistry at the University of Wisconsin, Madison, Dr. Litwack worked on enzymology and the effects of hormones on enzyme systems. Then he was a Postdoctoral Fellow of the National Foundation for Infantile Paralysis at the Biochemical Institute of the Sorbonne in Paris. Dr. Litwack's first position was as Assistant Professor of Biochemistry at Rutgers University in 1954. Six years later, he joined the University of Pennsylvania as associate professor and four years later went to the Fels Institute for Cancer Research and Molecular Biology, as full professor, eventually becoming Deputy Director of the Institute. In 1991, he accepted the Chair of Pharmacology at Thomas Jefferson University where he is also Deputy Director of the Jefferson Cancer Institute and Associate Director for Basic Science in the Jefferson Cancer Center. Dr. Litwack's work has been in the area of mechanisms of steroid receptor action involving especially the glucocorticoid and mineralocorticoid receptors, immunophi.