Neuronal Network Dynamics in 2D and 3D in vitro Neuroengineered Systems

1. Auflage 2016
ISBN: 978-3-319-30236-2
Verlag: Springer International Publishing

Buch, Englisch, 148 Seiten, HC runder Rücken kaschiert, Format (B × H): 160 mm x 241 mm, Gewicht: 3731 g

Reihe: Springer Theses

The book

presents a new, powerful model of neuronal networks, consisting of a

three-dimensional neuronal culture in which 3D neuronal networks are coupled to

micro-electrode-arrays (MEAs). It discusses the main advantages of the

three-dimensional system compared to its two-dimensional counterpart, and shows

that the network dynamics, recorded during both spontaneous and stimulated

activity, differs between the two models, with the 3D system being better able

to emulate the in vivo behaviour of neural networks. The book offers an

extensive analysis of the system, from the theoretical background, to its

design and applications in neuro-pharmacological studies. Moreover, it

includes a concise yet comprehensive introduction to both 2D and 3D neuronal

networks coupled to MEAs, and discusses the advantages, limitations and

challenges of their applications as cellular and tissue-like in vitro experimental model systems.

Zielgruppe

Research

Autoren/Hrsg.

Frega, Monica

Fachgebiete

• Technische Wissenschaften Elektronik | Nachrichtentechnik Elektronik
• Interdisziplinäres Wissenschaften Wissenschaften Interdisziplinär Neurowissenschaften, Kognitionswissenschaft
• Technische Wissenschaften Verfahrenstechnik | Chemieingenieurwesen | Biotechnologie Biotechnologie Biotechnologie: Mikrotechnologie, Nanobiotechnologie
• Medizin | Veterinärmedizin Medizin | Public Health | Pharmazie | Zahnmedizin Medizin, Gesundheitswesen Medizintechnik, Biomedizintechnik, Medizinische Werkstoffe
• Technische Wissenschaften Sonstige Technologien | Angewandte Technik Medizintechnik, Biomedizintechnik
• Naturwissenschaften Biowissenschaften Zellbiologie
• Mathematik | Informatik EDV | Informatik Informatik Künstliche Intelligenz Neuronale Netzwerke
• Medizin | Veterinärmedizin Medizin | Public Health | Pharmazie | Zahnmedizin Klinische und Innere Medizin Neurologie, Klinische Neurowissenschaft

Inhaltsverzeichnis

Introduction.- Dissociated Neuronal Networks Coupled to
Micro-Electrode Arrays Devices.- In Vitro Neuronal Networks.- 3D Neuronal
Networks: State of the Art.- 3D Neuronal Networks Coupled to MEAs.- Neuro-pharmacological
Studies.- Discussion and Conclusion.- Data Analysis.