Friedrich Supramolecular Enzyme Organization

Quaternary Structure and Beyond
1. Auflage 2014
ISBN: 978-1-4831-4783-3
Verlag: Elsevier Science & Techn.
Format: PDF
Kopierschutz: 1 - PDF Watermark

E-Book, Englisch, 316 Seiten, Web PDF

Supramolecular Enzyme Organization: Quaternary Structure and Beyond provides a comprehensive discussion of enzyme interactions. It attempts to place conceptually related phenomena in a common perspective by first scrutinizing enzyme interactions at the quaternary level and then moving on towards higher orders of organization. The book begins with a discussion of the hierarchy of enzymes, covering the structure of monomeric enzymes, enzyme structures beyond the monomeric stage, and protein-protein interactions. Separate chapters cover the chemistry of protein associations; the quaternary structure of enzymes; multienzyme systems; multienzyme complexes and conjugates; the association of enzymes with cellular structures; and metabolite compartmentation. The final chapters discuss trends in the study of enzyme systems and the dialectics of enzymology. This book is intended, not for the specialist, who knows much more about the individual questions than the text offers, but rather for the general biochemical reader interested in enzyme organization. There is practically no mathematics involved. Instead, quite elementary things are described, so that students and biologists with less background knowledge on enzymes will be able to join in.

Autoren/Hrsg.

Friedrich, Peter

Inhaltsverzeichnis

1;Front Cover;1
2;Supramolecular Enzyme Organization:
Quaternary Structure and Beyond;4
3;Copyright Page;5
4;Table of Contents;10
5;PREFACE;6
6;ACKNOWLEDGEMENTS;8
7;LIST OF ABBREVIATIONS;16
8;CHAPTER 1. THE HIERARCHY OF ENZYME STRUCTURES;18
8.1;STRUCTURE OF MONOMERIC ENZYMES;18
8.2;ENZYME STRUCTURES BEYOND THE MONOMERIC STAGE;19
8.3;THE CONCEPTUAL FRAMEWORK OF PROTEIN-PROTEIN INTERACTIONS;21
9;CHAPTER 2. CHEMISTRY OF PROTEIN ASSOCIATIONS;22
9.1;THE CONCEPT OF COMPLEMENTARY SURFACES;22
9.2;COMPLEMENTARY PROTEIN SURFACES ARE TIGHTLY PACKED;24
9.3;ABOUT THE PREDOMINANT ROLE OF HYDROPHOBIC INTERACTIONS;25
9.4;ELECTROSTATIC EFFECTS MAINLY CONTRIBUTE TO THE SPECIFICITY OF PROTEIN ASSOCIATIONS;26
10;CHAPTER 3. INTRAMOLECULAR ORGANIZATION: THE QUATERNARY STRUCTURE OF ENZYMES;28
10.1;OLIGOMERIC ENZYMES;28
10.2;NUMBER OF SUBUNITS IN OLIGOMERIC ENZYMES;28
10.3;SUBUNIT ARRANGEMENTS IN OLIGOMERIC ENZYMES;32
10.4;BIOLOGICAL ROLES OF OLIGOMERIC STRUCTURE;63
10.5;COMPLEX ENZYMES;89
11;CHAPTER 4. INTERMOLECULAR ORGANIZATION: MULTIENZYME SYSTEMS;97
11.1;FUNCTIONAL VS. STRUCTURAL ORGANIZATION;97
11.2;COORDINATE REGULATORY EFFECTS;107
12;CHAPTER 5. MULTIENZYME COMPLEXES AND CONJUGATES;109
12.1;STABLE MULTIENZYME COMPLEXES;109
12.2;TRYPTOPHAN SYNTHASE;110
12.3;THE a-KETOACID DEHYDROGENASE MULTIENZYME COMPLEXES;114
12.4;INTERCONVERTIBLE ENZYMES AND ENZYME CASCADES;120
12.5;MULTIENZYME CONJUGATES;121
12.6;MULTIENZYME COMPLEX-CONJUGATES;130
12.7;INTERACTIONS BETWEEN "SOLUBLE" ENZYMES;132
13;CHAPTER 6. ASSOCIATION OF ENZYMES WITH CELLULAR STRUCTURES;144
13.1;ENZYMES INCORPORATED INTO STRUCTURES;145
13.2;ENZYMES LOOSELY BOUND TO STRUCTURES;169
13.3;GLYCOLYTIC ENZYMES AND THE CONTRACTILE APPARATUS;170
13.4;GLYCOLYSIS AND THE ERYTHROCYTE MEMBRANE;174
14;CHAPTER 7. METABOLITE COMPARTMENTATION;197
14.1;THE CELL AS BASIC COMPARTMENT;197
14.2;INTRACELLULAR COMPARTMENTS AND METABOLITE POOLS;198
14.3;MACROCOMPARTMENTS: PLASMATIC AND NON-PLASMATIC;200
14.4;MICROCOMPARTMENTS;205
15;CHAPTER 8. CURRENT TRENDS IN THE STUDY OF ENZYME SYSTEMS;224
15.1;MATHEMATICAL MODELLING OF ENZYME SYSTEMS;224
15.2;STUDY OF ENZYMES IN VIVO;227
15.3;SYSTEMIC APPROACH TO METABOLIC CONTROL;231
15.4;FUNCTIONAL COMPLEMENTARITY BETWEEN ENZYMES;235
16;CHAPTER 9. ENZYME ORGANIZATION: SUMMARY AND PERSPECTIVES;240
16.1;THE DIALECTICS OF ENZYMOLOGY: AWAY FROM AND BACK TO THE LIVING CELL;240
16.2;THE THIRD DIMENSION OF METABOLIC MAPS;241
16.3;THE DIVIDENDS OF COMPLEXITY;243
16.4;ENZYMOLOGY OF THE 21ST CENTURY;246
17;REFERENCES;247
18;SUBJECT INDEX;312