Functional Neural Transplantation III

Primary and Stem Cell Therapies for Brain Repair, Part I
Erscheinungsjahr 2012
ISBN: 978-0-444-59575-1
Verlag: Elsevier Science & Technology

Buch, Englisch, 448 Seiten, Format (B × H): 191 mm x 235 mm, Gewicht: 1080 g

This issue of Progress in Brain Research is split over 2 volumes, bringing together cutting-edge research on functional neural transplantation. The 2 volumes review current knowledge and understanding, provide a starting point for researchers and practitioners entering the field, and build a platform for further research and discovery.

Zielgruppe

Neuroscientists, psychologists, neurologists

Autoren/Hrsg.

Weitere Mitwirkende

Dunnett, Stephen B.

Bjorklund, Anders

Fachgebiete

• Medizin | Veterinärmedizin Medizin | Public Health | Pharmazie | Zahnmedizin Vorklinische Medizin: Grundlagenfächer Molekulare Medizin, Zellbiologie
• Medizin | Veterinärmedizin Medizin | Public Health | Pharmazie | Zahnmedizin Chirurgie Neurochirurgie
• Medizin | Veterinärmedizin Medizin | Public Health | Pharmazie | Zahnmedizin Klinische und Innere Medizin Neurologie, Klinische Neurowissenschaft

Inhaltsverzeichnis

- Preface

Stephen Dunnett and Anders Björklund

- Transplantation in the Future

Fred H. Gage

- Ethical Challenges for Using Human Cells in Clinical Cell Therapy

Göran Hermerén

- Banking Stem Cells for Research and Clinical Applications

Glyn Stacey

- Survival, Differentiation and Connectivity of Ventral Mesencephalic Dopamine Neurons following Transplantation

Lachlan Thompson and Anders Björklund

- Electrophysiological Investigations of Synaptic Connectivity between Host and Graft Neurons

Jan Tønnesen and Merab Kokaia

- Nigral Grafts in Animal Models of Parkinson's Disease. Is Recovery beyond Motor Function Possible?

Mariah J. Lelos, Eilís Dowd and Stephen B. Dunnett

- L-DOPA- and Graft-Induced Dyskinesia following Transplantation

Emma L. Lane and Christian Winkler

- Current Status of Clinical Trials of Neural Transplantation in Parkinson's Disease

Jonathan R Evans, Sarah L Mason and Roger A Barker

- In vivo Imaging of the Integration and Function of Nigral Grafts in Clinical Trials

Marios Politis and Paola Piccini

- Neuropathology in Transplants in Parkinson's Disease: Implications for Disease Pathogenesis and the Future of Cell Therapy

Patrik Brundin and Jeffrey H. Kordower

- Derivation of Dopaminergic Neurons from Pluripotent Stem Cells

Lorenz Studer

- Characterization and Criteria of Embryonic Stem and Induced Pluripotent Stem Cells for a Dopamine Replacement Therapy

Oliver Cooper, Malin Parmar and Ole Isacson

- Skilled Motor Control for the Preclinical Assessment of Functional Deficits and Recovery following Nigral and Striatal Cell Transplantation

Alexander Klein and Ian Q. Whishaw

- Role of Experience, Training and Plasticity in the Functional Efficacy of Striatal Transplants

Máté D. Döbrössy and Guido Nikkhah

- In vivo Imaging of Integration and Function of Striatal Grafts in Rodent and Non-Human Primate Animal Models

Philippe Hantraye and Romina Aron Badin

- Clinical Trials of Neural Transplantation in Huntington's Disease

Anne E. Rosser and Anne-Catherine Bachoud-Lévi

- Derivation of Striatal Neurons from Human Stem Cells Pedro Viegas, Camille Nicoleau and Anselme L. Perrier

Über Autor(innen)

Dunnett, Stephen B.
Dunnett is a behavioural neuroscientist who started a lifelong collaboration with the Björklund team in 1979 to explore the functional consequences of cell transplantation method in animal models of neurodegenerative disease, in particular involving cell replacement and repair of the basal ganglia. He has developed models and novel methods of motor and cognitive assessment to apply behavioural analysis not simply to assess functional efficacy of implanted cells, but as a tool to study the mechanisms of cell integration, circuit reconstruction and functional repair. In parallel his laboratory originated the first UK trial of cell transplantation in Huntington's disease, and provides the source of clinical grade cells for further ongoing trials in Parkinson's disease.

Bjorklund, Anders
As a neuroanatomist and developmental neurobiologist, during the 1970s Björklund's lab originated reliable methods for transplantation of embryonic tissues into brain that pioneered practical cell transplantation in the central nervous system, providing the basis for technologies that are now used by laboratories world-wide. In parallel, work in the field has progressed from basic anatomical and developmental studies in experimental animals, via applications for assessing cell replacement and repair using primary and stem cells in the damaged brain, and now underpinning the majority of methods in development for cell therapy in patients. His laboratory continues to analyse the fundamental neurobiology and principles of cell transplantation, regeneration and integration in the CNS, as well as originating the first trials of effective clinical cell transplantation (for Parkinson's disease) in patients