Genetics of Epilepsy

Erscheinungsjahr 2014
ISBN: 978-0-444-63326-2
Verlag: Elsevier Science & Technology

Buch, Englisch, 346 Seiten, Format (B × H): 191 mm x 235 mm, Gewicht: 780 g

The book chapters cover different aspects of epilepsy genetics, starting with the "classical" concept of epilepsies as ion channel disorders. The second part of the book gives credit to the fact that by now non-ion channel genes are recognized as equally important causes of epilepsy. The concluding chapters are designed to offer the reader insight into current methods in epilepsy research. Each chapter is self-contained and deals with a selected topic of interest.

Zielgruppe

Neuroscientists, psychologists, neurologists. The volume will serve as an outstanding reference for both those just entering the field and experts seeking an update on this fast moving area.

Autoren/Hrsg.

Weitere Mitwirkende

Steinlein, Ortrud

Fachgebiete

• Interdisziplinäres Wissenschaften Wissenschaften Interdisziplinär Neurowissenschaften, Kognitionswissenschaft
• Sozialwissenschaften Psychologie Allgemeine Psychologie Biologische Psychologie, Neuropsychologie
• Medizin | Veterinärmedizin Medizin | Public Health | Pharmazie | Zahnmedizin Klinische und Innere Medizin Neurologie, Klinische Neurowissenschaft

Inhaltsverzeichnis

- Genetic Heterogeneity in Familial Nocturnal Frontal Lobe Epilepsy

Ortrud K. Steinlein

- Potassium Channel Genes and Benign Familial Neonatal Epilepsy

Snezana Maljevic and Holger Lerche

- Mutant GABAA Receptor Subunits in Genetic (Idiopathic) Epilepsy

Shinichi Hirose

- The Role of Calcium Channel Mutations in Human Epilepsy

Antonio Gambardella and Angelo Labate

- Mechanisms Underlying Epilepsies Associated with Sodium Channel Mutations

Ortrud K. Steinlein

- The Progressive Myoclonus Epilepsies

Berge A. Minassian

- Genetics Advances in Autosomal Dominant Focal Epilepsies: Focus on DEPDC5

Stéphanie Baulac

- PRRT2: A Major Cause of Infantile Epilepsy and other Paroxysmal Disorders of Childhood

Carlo Nobile and Pasquale Striano

- LGI1: From Zebrafish to Human Epilepsy

John K. Cowell

- Morphogenesis and Timing of Genetically-Programmed Brain Malformations in Relation to Epilepsy

Harvey B. Sarnat and Laura Flores-Sarnat

- Remind Me Again What Disease We are Studying? A Population Genetics, Genetic Analysis, and Real Data Perspective on Why Progress on Identifying Genetic Influences on Common Epilepsies has Been So Slow

David A. Greenberg and William L. Stewart

- Monogenic Models of Absence Epilepsy: Windows into the Complex Balance between Inhibition and Excitation in Thalamocortical Microcircuits

Atul Maheshwari and Jeffrey L. Noebels

- New Technologies in Molecular Genetics: The Impact on Epilepsy Research

Ingo Helbig

- Epigenetic Mechanisms in Epilepsy Katja Kobow and Ingmar Blümcke