Gregoriadis / Senior / Poste Targeting of Drugs With Synthetic Systems

Erscheinungsjahr 2013
ISBN: 978-1-4684-5185-6
Verlag: Springer US
Format: PDF
Kopierschutz: 1 - PDF Watermark

E-Book, Englisch, Band 113, 308 Seiten, eBook

Reihe: NATO Science Series A:

Targeting of drugs via carrier systems to sites in the body in need of pharmacologic intervention is a rapidly growing area of research in the treatment or prevention of disease. It has evolved from the need to preferentially deliver drugs, enzymes, vitamins, hormones, antigens, etc. to target cells and organs so as to avoid toxicity, waste of drugs through premature secretion or inactivation and at the same time render treatment more convenient and cost-effective. A wide assortment of naturally occ urring or semi-synthetic drug carriers (e. g. antibodies, glycoproteins, lectins, peptide hormones, cells and liposomes), their inter action with relevant receptors and mediation of optimal pharmacological action were discussed in the two previous NATO Advanced Studies Institutes (ASI) of this series, "Targeting of Drugs" and "Receptor-Mediated Targeting of Drugs", the proceedings of wh ich were published by Plenum in 1982 and 1984 respectively. This book contains the proceedings of the 3rd NATO ASI "Targeting of Drugs with Synthetic Systems" held as be fore at Cape Sounion, Greece during 24 June-5 July 1985. It deals mostly with man-made carriers such as a variety of polymers, matrices, liposomes and other colloidal micro particles. The twenty chapters discuss the interaction of such carriers with the biological milieu, approaches to bypass the reticuloendothelial system (or, when needed, take advantage of its interception of carriers to optimally deliver drugs to phagocytes) and ways to improve delivery to specific cells, often with the help of carrier-linked ligands.

Zielgruppe

Research

Autoren/Hrsg.

Gregoriadis, Gregory

Senior, Judith

Poste, George

Inhaltsverzeichnis

Mannose Binding Proteins in the Liver and Blood.- Cell Membrane Molecules on Neoplastic Cells: Their Role in Malignant Cell Transformation and Dissemination.- Tumor-Associated Glycolipid Markers: Possible Targets for Drug and Immunotoxin Delivery.- Interaction of Macromolecular Drugs with Receptors.- Endocytosis and Lysosomes: Recent Progress in Intracellular Traffic.- Peptides as Targets and Carriers.- Hepatic Functions in Health and Disease: Implications in Drug Carrier Use.- Targeting with Synthetic Polymers: A Realistic Goal.- Drug-Poly(lysine) Conjugates: Their Potential for Chemotherapy and for the Study of Endocytosis.- Targeting of Colloidal Carriers and the Role of Surface Properties.- Targetable Nanoparticles.- Polymers as Matrices for Drug Release.- Liposomes In-Vivo: A Relationship Between Stability and Clearance?.- Liposomes as Drug Carriers to Liver Macrophages: Fundamental and Therapeutic Aspects.- Alternate Delivery of Interferons.- Liposomes in Antimicrobial Therapy.- Design, Characterization and Antitumor Activity of Adriamycin-Containing Phospholipid Vesicles.- Particle Charge and Surface Hydrophobicity of Colloidal Drug Carriers.- Particle Size Analysis of Colloidal Systems by Photon Correlation Spectroscopy.- Stability of Liposomes on Storage.- Contributors.